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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">detinf</journal-id><journal-title-group><journal-title xml:lang="ru">ДЕТСКИЕ ИНФЕКЦИИ</journal-title><trans-title-group xml:lang="en"><trans-title>CHILDREN INFECTIONS</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-8107</issn><issn pub-type="epub">2618-8139</issn><publisher><publisher-name>Association of Pediatricians and Infection Disease doctors</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22627/2072-8107-2015-14-2-30-34</article-id><article-id custom-type="elpub" pub-id-type="custom">detinf-108</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW OF THE LITERATURE</subject></subj-group></article-categories><title-group><article-title>АНТИБИОТИКО-АССОЦИИРОВАННЫЕ ДИАРЕИ И CL. DIFFICILE-ИНФЕКЦИЯ У ДЕТЕЙ: ФАКТОРЫ РИСКА</article-title><trans-title-group xml:lang="en"><trans-title>ANTIBIOTIC-ASSOCIATED DIARRHEA AND CL. DIFFICILE-INFECTION IN CHILDREN: RISK FACTORS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мазанкова</surname><given-names>Л. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Mazankova</surname><given-names>L. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., проф., зав. каф. детских инфекционных болезней ГБОУ ДПО РМАПО МЗ РФ; 125373, г. Москва, ул. Героев Панфиловцев, д.28; +7 (495) 949-17-22</p></bio><bio xml:lang="en"><p>doctor of Medical Science, Department of Infectious Diseases, Professor</p></bio><email xlink:type="simple">mazankova@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Перловская</surname><given-names>С. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Perlovskaya</surname><given-names>S. G.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ГБОУ ДПО Российская медицинская академия последипломного образования МЗ РФ, кафедра детских инфекционных болезней, Москва<country>Россия</country></aff><aff xml:lang="en">Department of Pediatric Infiectious Diseases, Russian Medical Academy of Postgraduate Education, Ministry of Health of the Russian Federation, Moscow<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ГБУЗ Детская городская клиническая больница № 9 им. Г.Н. Сперанского ДЗМ<country>Россия</country></aff><aff xml:lang="en">Children's City Clinical Hospital № 9 named after G. N. Speransky, Moscow<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>03</day><month>09</month><year>2015</year></pub-date><volume>14</volume><issue>2</issue><fpage>29</fpage><lpage>34</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мазанкова Л.Н., Перловская С.Г., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Мазанкова Л.Н., Перловская С.Г.</copyright-holder><copyright-holder xml:lang="en">Mazankova L.N., Perlovskaya S.G.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://detinf.elpub.ru/jour/article/view/108">https://detinf.elpub.ru/jour/article/view/108</self-uri><abstract><p>В обзоре литературы представлены данные о частоте развития и особенностях течения антибиотико-ассоциированных диарей (ААД) у детей. Изложены материалы исследований отечественных и зарубежных ученых о факторах риска активации токсигенных штаммов Cl. difficile, показана связь между глубиной микроэкологических метаболомных нарушений и Cl. difficile-инфекцией у детей.</p></abstract><trans-abstract xml:lang="en"><p>The review of literature presents data on the incidence and characteristics of the current development of antibiotic-associated diarrhea (AAD) in children. Presented research materials of Russian and foreign scientists on risk factors activation toxigenic strains Cl. difficile, showed the relationship between the depth microecologi-cal metabolomical violations and Cl. difficile-infection in children.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>антибиотики</kwd><kwd>диарея</kwd><kwd>дети</kwd><kwd>Cl. difficile-инфекция</kwd></kwd-group><kwd-group xml:lang="en"><kwd>antibiotics</kwd><kwd>diarrhea</kwd><kwd>children</kwd><kwd>Cl. difficile-infection</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Баранов А.А. Применение антибиотиков у детей в амбулаторной практике. Методические рекомендации /А.А. Баранов, Л.С. Страчунский // Клиническая микробиология и антимикробная химиотерапия. — 2007. — № 9 (3). — С. 200—210. Baranov A.A., Strachunskiy L.S. 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