<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">detinf</journal-id><journal-title-group><journal-title xml:lang="ru">ДЕТСКИЕ ИНФЕКЦИИ</journal-title><trans-title-group xml:lang="en"><trans-title>CHILDREN INFECTIONS</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-8107</issn><issn pub-type="epub">2618-8139</issn><publisher><publisher-name>Association of Pediatricians and Infection Disease doctors</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22627/2072-8107-2025-24-4-5-9</article-id><article-id custom-type="elpub" pub-id-type="custom">detinf-1109</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Микоплазменная пневмония у детей Смоленской области в 2023 и 2024 гг.: фокус внимания на клинико-лабораторные параллели</article-title><trans-title-group xml:lang="en"><trans-title>Mycoplasma pneumonia in children of the Smolensk region in 2023 and 2024: focus on clinical and laboratory parallels</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2845-9983</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Литвинова</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Litvinova</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Литвинова Александра Алексеевна, ассистент, аспирант кафедры инфекционных болезней у детей СГМУ </p><p>Смоленск </p></bio><email xlink:type="simple">Alexa5582@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6993-590X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соколовская</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sokolovskaya</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Соколовская Влада Вячеславовна, к.м.н., доцент, заведующая кафедрой инфекционных болезней у детей СГМУ </p><p>Смоленск </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5686-4823</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козлов</surname><given-names>Р. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozlov</surname><given-names>R. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Козлов Роман Сергеевич, д.м.н., член-корреспондент РАН; ректор СГМУ </p><p>Смоленск </p></bio><email xlink:type="simple">roman.kozlov@antibiotic.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Смоленский государственный медицинский университет Министерства здравоохранения Российской Федерации</institution></aff><aff xml:lang="en"><institution>Smolensk State Medical University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>27</day><month>11</month><year>2025</year></pub-date><volume>24</volume><issue>4</issue><fpage>5</fpage><lpage>9</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Литвинова А.А., Соколовская В.В., Козлов Р.С., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Литвинова А.А., Соколовская В.В., Козлов Р.С.</copyright-holder><copyright-holder xml:lang="en">Litvinova A.A., Sokolovskaya V.V., Kozlov R.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://detinf.elpub.ru/jour/article/view/1109">https://detinf.elpub.ru/jour/article/view/1109</self-uri><abstract><p>Наблюдения последних лет показывают, что случаи микоплазменной пневмонии (МРР) встречаются не только в старшей возрастной группе, но и у детей младшего возраста, протекают с выраженной лихорадкой и симптомами интоксикации, также отмечается рост числа случаев рефрактерных пневмоний и мультисистемных осложнений. Цель: провести сравнительный анализ и выявить особенности клинических проявлений и результатов дополнительных методов обследования у детей с МРР в Смоленской области за период с 01.01.23 по 31.12.23 (n = 116) и с 01.01.24 по 31.12.24 (n = 85). Результаты: за исследуемые промежутки времени в структуре заболеваемости МРР преобладали дети старшей возрастной группы. На первый план у 89% детей в 2024 г. на момент госпитализации выступали признаки лихорадочно-интоксикационного синдрома. У 8% больных регистрировался бронхообструктивный синдром. У 35% детей отмечалась брадикардия — нарушение адекватного адаптивного ответа организма на лихорадку в виде повышения ЧСС. Основными осложнениями за исследуемые временные промежутки стали: дыхательная недостаточность (ДН) 1 и 2 степеней, плеврит. Представлены случаи ко- и суперинфекций. Наиболее часто выявляемыми изменениями периферической крови были: эритроцитоз, относительный лимфоцитоз, тромбоцитоз, повышение СОЭ и СРБ. Стартовым препаратом выбора на амбулаторном этапе чаще всего был амоксиклав, что связано с отсутствием «классической» симптоматики МРР, не позволяющей в ранние сроки заподозрить атипичную этиологию заболевания. Заключение. В большинстве случаев МРР у детей не имела «классических» клинико-лабораторных особенностей, что существенно затрудняло своевременную диагностику и удлиняло время начала назначения этиотропной терапии. Кроме того, выявлено отсутствие параллелизма между клиническими симптомами и лабораторными маркерами.</p></abstract><trans-abstract xml:lang="en"><p>Recent observations show that cases of mycoplasma pneumonia (MРP) occur not only in the older age group, but also in young children, with severe fever and symptoms of intoxication, and an increase in the number of cases of refractory pneumonia and multisystem complications. Objective: conduct a comparative analysis and identify the features of clinical manifestations and the results of additional examination methods in children with MРР in the Smolensk region for the period from 01.01.23 to 31.12.23 (n = 116) and from 01.01.24 to 31.12.24 (n = 85). Results: Over the studied time periods, the structure of MРР incidence was dominated by children of the older age group. 89% of children in 2024 showed signs of fever intoxication syndrome at the time of hospitalization. Bronchoobstructive syndrome was registered in 8% of patients. 35% of children had bradycardia, a violation of the body's adequate adaptive response to fever in the form of increased heart rate. The main complications during the time periods studied were: respiratory failure of the 1st and 2nd degrees, pleurisy. Cases of co- and superinfections are presented. The most frequently detected changes in peripheral blood were: erythrocytosis, relative lymphocytosis, thrombocytosis, increased ESR and CRP. The initial drug of choice at the outpatient stage was most often amoxiclav, which is due to the absence of «classic» symptoms of MРР, which does not allow one to suspect the atypical etiology of the disease at an early stage. Conclusion. In most cases, MРР in children did not have «classical» clinical and laboratory features, which significantly hampered timely diagnosis and, consequently, lengthened the start time of etiotropic therapy. In addition, there was no parallelism between clinical symptoms and laboratory markers. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>микоплазменная пневмония</kwd><kwd>дети</kwd><kwd>лабораторные маркеры</kwd><kwd>визуализационные методы исследования</kwd></kwd-group><kwd-group xml:lang="en"><kwd>mycoplasma pneumonia</kwd><kwd>children</kwd><kwd>laboratory markers</kwd><kwd>imaging research methods</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kumar S, Kumar S. Mycoplasma pneumoniae: Among the smallest bacterial pathogens with great clinical significance in children. Indian J Med Microbiol. 2023 Nov-Dec; 46:100480. doi: 10.1016/j.ijmmb.2023.100480</mixed-citation><mixed-citation xml:lang="en">Kumar S, Kumar S. Mycoplasma pneumoniae: Among the smallest bacterial pathogens with great clinical significance in children. Indian J Med Microbiol. 2023 Nov-Dec; 46:100480. doi: 10.1016/j.ijmmb.2023.100480</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Kumar S. Mycoplasma pneumoniae: A significant but underrated pathogen in paediatric community-acquired lower respiratory tract infections. Indian J Med Res. 2018 Jan;147(1):23-31. doi: 10.4103/ijmr.IJMR_1582_16</mixed-citation><mixed-citation xml:lang="en">Kumar S. Mycoplasma pneumoniae: A significant but underrated pathogen in paediatric community-acquired lower respiratory tract infections. Indian J Med Res. 2018 Jan;147(1):23-31. doi: 10.4103/ijmr.IJMR_1582_16</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Song Z, Jia G, Luo G, Han C, Zhang B, Wang X. Global research trends of Mycoplasma pneumoniae pneumonia in children: a bibliometric analysis. Front Pediatr. 2023 Nov 24; 11:1306234. doi: 10.3389/fped.2023.1306234</mixed-citation><mixed-citation xml:lang="en">Song Z, Jia G, Luo G, Han C, Zhang B, Wang X. Global research trends of Mycoplasma pneumoniae pneumonia in children: a bibliometric analysis. Front Pediatr. 2023 Nov 24; 11:1306234. doi: 10.3389/fped.2023.1306234</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Waites KB, Xiao L, Liu Y, Balish MF, Atkinson TP. Mycoplasma pneumoniae from the Respiratory Tract and Beyond. Clin Microbiol Rev. 2017 Jul; 30(3):747—809. doi: 10.1128/CMR.00114-16</mixed-citation><mixed-citation xml:lang="en">Waites KB, Xiao L, Liu Y, Balish MF, Atkinson TP. Mycoplasma pneumoniae from the Respiratory Tract and Beyond. Clin Microbiol Rev. 2017 Jul; 30(3):747—809. doi: 10.1128/CMR.00114-16</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Onozuka D, Chaves LF. Climate variability and nonstationary dynamics of Mycoplasma pneumoniae pneumonia in Japan. PLoS One. 2014 Apr 16; 9(4):e95447. doi: 10.1371/journal.pone.0095447</mixed-citation><mixed-citation xml:lang="en">Onozuka D, Chaves LF. Climate variability and nonstationary dynamics of Mycoplasma pneumoniae pneumonia in Japan. PLoS One. 2014 Apr 16; 9(4):e95447. doi: 10.1371/journal.pone.0095447</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Spuesens EBM, Oduber M, Hoogenboezem T, Sluijter M, Hartwig NG, van Rossum AMC, Vink C. Sequence variations in RepMP2/3 and RepMP4 elements reveal intragenomic homologous DNA recombination events in Mycoplasma pneumoniae. Microbiology (Reading). 2009 Jul; 155(Pt 7):2182— 2196. doi: 10.1099/mic.0.028506-0</mixed-citation><mixed-citation xml:lang="en">Spuesens EBM, Oduber M, Hoogenboezem T, Sluijter M, Hartwig NG, van Rossum AMC, Vink C. Sequence variations in RepMP2/3 and RepMP4 elements reveal intragenomic homologous DNA recombination events in Mycoplasma pneumoniae. Microbiology (Reading). 2009 Jul; 155(Pt 7):2182— 2196. doi: 10.1099/mic.0.028506-0</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Xiao J, Liu Y, Wang M, Jiang C, You X, Zhu C. Detection of Mycoplasma pneumoniae P1 subtype variations by denaturing gradient gel electrophoresis. Diagn Microbiol Infect Dis. 2014 Jan; 78(1):24—8. doi: 10.1016/j.diagmicrobio.2013.08.008</mixed-citation><mixed-citation xml:lang="en">Xiao J, Liu Y, Wang M, Jiang C, You X, Zhu C. Detection of Mycoplasma pneumoniae P1 subtype variations by denaturing gradient gel electrophoresis. Diagn Microbiol Infect Dis. 2014 Jan; 78(1):24—8. doi: 10.1016/j.diagmicrobio.2013.08.008</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Liu J, He R, Zhang X, Zhao F, Liu L, Wang H, Zhao S. Clinical features and «early» corticosteroid treatment outcome of pediatric mycoplasma pneumoniae pneumonia. Front Cell Infect Microbiol. 2023 Apr 4; 13:1135228. doi: 10.3389/fcimb.2023.1135228</mixed-citation><mixed-citation xml:lang="en">Liu J, He R, Zhang X, Zhao F, Liu L, Wang H, Zhao S. Clinical features and «early» corticosteroid treatment outcome of pediatric mycoplasma pneumoniae pneumonia. Front Cell Infect Microbiol. 2023 Apr 4; 13:1135228. doi: 10.3389/fcimb.2023.1135228</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Atkinson TP, Waites KB. Mycoplasma pneumoniae Infections in Childhood. Pediatr Infect Dis J. 2014 Jan; 33(1):92—4. doi: 10.1097/INF.0000000000000171</mixed-citation><mixed-citation xml:lang="en">Atkinson TP, Waites KB. Mycoplasma pneumoniae Infections in Childhood. Pediatr Infect Dis J. 2014 Jan; 33(1):92—4. doi: 10.1097/INF.0000000000000171</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Gadsby NJ, Reynolds AJ, McMenamin J, Gunson RN, McDonagh S, Molyneaux PJ, Yirrell DL, Templeton KE. Increased reports of Mycoplasma pneumoniae from laboratories in Scotland in 2010 and 2011 — impact of the epidemic in infants. Euro Surveill. 2012 Mar 8; 17(10):20110</mixed-citation><mixed-citation xml:lang="en">Gadsby NJ, Reynolds AJ, McMenamin J, Gunson RN, McDonagh S, Molyneaux PJ, Yirrell DL, Templeton KE. Increased reports of Mycoplasma pneumoniae from laboratories in Scotland in 2010 and 2011 — impact of the epidemic in infants. Euro Surveill. 2012 Mar 8; 17(10):20110</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Poddighe D, Demirkaya E, Sazonov V, Romano M. Mycoplasma pneumoniae Infections and Primary Immune Deficiencies. Int J Clin Pract. 2022 Jul 8; 2022:6343818. doi: 10.1155/2022/6343818</mixed-citation><mixed-citation xml:lang="en">Poddighe D, Demirkaya E, Sazonov V, Romano M. Mycoplasma pneumoniae Infections and Primary Immune Deficiencies. Int J Clin Pract. 2022 Jul 8; 2022:6343818. doi: 10.1155/2022/6343818</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Эйдельштейн И.А. Mycoplasma pneumoniae-современные данные о строении, молекулярной биологии и эпидемиологии возбудителя. Клиническая микробиология и антимикробная химиотерапия. 2023; 25(4): 332— 349.</mixed-citation><mixed-citation xml:lang="en">Jejdel'shtejn I.A. Mycoplasma pneumoniae-current data on the structure, molecular biology and epidemiology of the pathogen. Klinicheskaja mikrobiologija i antimikrobnaja himioterapija = Clinical microbiology and antimicrobial chemotherapy. 2023; 25(4): 332—349. (In Russ.]</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Авдеева Е.С., Солопова Е.В., Брыкина О.В., Иванникова А.С., Леднёва В.С. Современные варианты клинического течения микоплазменной инфекции у детей. Российский педиатрический журнал. 2025; 28(4S):11.</mixed-citation><mixed-citation xml:lang="en">Avdeeva E.S., Solopova E.V., Brykina O.V., Ivannikova A.S., Lednjova V.S. Modern variants of the clinical course of mycoplasma infection in children. Rossijskij pediatricheskij zhurnal = Russian Pediatric Journal. 2025; 28(4S): 11. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Li J, Zhang H, Guo J, Ma X. Clinical features of Mycoplasma pneumoniae pneumonia in children without fever. BMC Pediatr. 2024 Jan 16; 24(1):52. doi: 10.1186/s12887-023-04512-1</mixed-citation><mixed-citation xml:lang="en">Li J, Zhang H, Guo J, Ma X. Clinical features of Mycoplasma pneumoniae pneumonia in children without fever. BMC Pediatr. 2024 Jan 16; 24(1):52. doi: 10.1186/s12887-023-04512-1</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">He XY, Wang XB, Zhang R, Yuan ZJ, Tan JJ, Peng B, Huang Y, Liu EM, Fu Z, Bao LM, Zou L. Investigation of Mycoplasma pneumoniae infection in pediatric population from 12,025 cases with respiratory infection. Diagn Microbiol Infect Dis. 2013 Jan; 75(1):22—7. doi: 10.1016/j.diagmicrobio.2012.08.027</mixed-citation><mixed-citation xml:lang="en">He XY, Wang XB, Zhang R, Yuan ZJ, Tan JJ, Peng B, Huang Y, Liu EM, Fu Z, Bao LM, Zou L. Investigation of Mycoplasma pneumoniae infection in pediatric population from 12,025 cases with respiratory infection. Diagn Microbiol Infect Dis. 2013 Jan; 75(1):22—7. doi: 10.1016/j.diagmicrobio.2012.08.027</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Kannan TR, Hardy RD, Coalson JJ, Cavuoti DC, Siegel JD, Cagle M, Musatovova O, Herrera C, Baseman JB. Fatal outcomes in family transmission of Mycoplasma pneumoniae. Clin Infect Dis. 2012 Jan 15; 54(2):225—31. doi: 10.1093/cid/cir769</mixed-citation><mixed-citation xml:lang="en">Kannan TR, Hardy RD, Coalson JJ, Cavuoti DC, Siegel JD, Cagle M, Musatovova O, Herrera C, Baseman JB. Fatal outcomes in family transmission of Mycoplasma pneumoniae. Clin Infect Dis. 2012 Jan 15; 54(2):225—31. doi: 10.1093/cid/cir769</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Мазанкова Л.Н. и др. Микоплазменная инфекция и COVID-19 — «красные флаги» диагностики и лечения. Российский вестник перинатологии и педиатрии. 2025; 70(1):56—63.</mixed-citation><mixed-citation xml:lang="en">Mazankova L.N. i dr. Mycoplasma infection and COVID-19 — «red flags» of diagnosis and treatment. Russian Bulletin of Perinatology and Pediatrics = Rossijskij vestnik perinatologii i pediatrii. 2025; 70(1):56—63. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Бевза С.Л., Молочкова О.В., Ковалев О.Б., Шамшева О.В. и др. Сравнительная характеристика пневмоний, вызванных Mycoplasma pneumoniae, у детей. Журнал инфектологии. 2023; 15(3)110—118. https://doi.org/10.22625/2072-6732-2023-15-3-110-118</mixed-citation><mixed-citation xml:lang="en">Bevza S.L., Molochkova O.V., Kovalev O.B., Shamsheva O.V., et al. Comparative characteristics of pneumonia caused by Mycoplasma pneumoniae in children. Journal of Infectology. 2023; 15(3)110—118. (In Russ.) https://doi.org/10.22625/2072-6732-2023-15-3-110-118</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Бевза С.Л., Паршина М.В., Молочкова О.В., Ковалев О.Б., Егорова Н.Ю., Сахарова А.А. Трудности в дифференциальной диагностике пневмоний у детей. Детские инфекции. 2025; 24(2):22—28. https://doi.org/10.22627/2072-8107-2025-24-2-22-28</mixed-citation><mixed-citation xml:lang="en">Bevza S.L., Parshina M.V., Molochkova O.V., Kovalev O.B., Egorova N.Yu., Sakharova A.A. Difficulties in differential diagnostics of pneumonia in children. Detskie Infektsii=Children Infections. 2025; 24(2):22—28. (In Russ.) https://doi.org/10.22627/2072-8107-2025-24-2-22-28</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Miyashita N, Akaike H, Teranishi H, Nakano T, Ouchi K, Okimoto N. Chest computed tomography for the diagnosis of Mycoplasma pneumoniae infection. Respirology. 2014 Jan; 19(1):144—5. doi: 10.1111/resp.12218</mixed-citation><mixed-citation xml:lang="en">Miyashita N, Akaike H, Teranishi H, Nakano T, Ouchi K, Okimoto N. Chest computed tomography for the diagnosis of Mycoplasma pneumoniae infection. Respirology. 2014 Jan; 19(1):144—5. doi: 10.1111/resp.12218</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
