detinfДЕТСКИЕ ИНФЕКЦИИCHILDREN INFECTIONS2072-81072618-8139Association of Pediatricians and Infection Disease doctors10.22627/2072-8107-2016-15-3-42-45detinf-245Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEW OF THE LITERATUREРОЛЬ ГЕНЕТИЧЕСКИХ ДЕТЕРМИНАНТ И НАРУШЕНИЙ В СИСТЕМНОМ И МЕСТНОМ ИММУНИТЕТЕ В ЭТИОЛОГИИ И ПАТОГЕНЕЗЕ ГЕРПЕТИЧЕСКОЙ ЭКЗЕМЫ (ЭКЗЕМЫ КАПОШИ)THE ROLE OF GENETIC DETERMINANTS AND DISORDERS IN SYSTEMIC AND LOCAL IMMUNITY IN THE ETIOLOGY AND PATHOGENESIS OF HERPETIC ECZEMA (KAPOSI'S ECZEMA)СтадниковаА. С.StadnikovaA. S.ТамразоваО. Б.TamrazovaO. BЧеботареваТ. А.ChebotarevaT. A.

Чеботарева Татьяна Александровна — доктор медицинских наук, профессор кафедры детских инфекционных

Chebotarevа Tatiana — DMS, Professor, Department of Pediatric Infectious Diseases

t_sheina@mail.ruМосковский научно-практический центр дерматовенерологии и косметологии, МоскваРоссияMoscow Scientific-Practical Center of dermatology and cosmetology, MoscowRussian FederationРоссийский университет дружбы народов; Детская городская клиническая больница имени З.А. Башляевой, МоскваРоссияRussian University of Peoples' Friendship; Children's City Clinical Hospital them Z.A. Bashlyaevoy, MoscowRussian FederationРоссийская медицинская академия последипломного образования, МоскваРоссияRussian Medical Academy of Postgraduate Education of the Ministry of Health of Russia, MoscowRussian Federation2016011020161534245Copyright © Стадникова А.С., Тамразова О.Б., Чеботарева Т.А., 20162016Стадникова А.С., Тамразова О.Б., Чеботарева Т.А.Stadnikova A.S., Tamrazova O.B., Chebotareva T.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://detinf.elpub.ru/jour/article/view/245

Представлен анализ данных литературы об этиологии и патогенезе герпетической экземы (экземы Капоши). Изложены современные представления о комплексе генетических и фенотипических детерминант заболевания, отражающие сложные взаимодействия между кожей и иммунной системой. Наряду с общей характеристикой закономерностей возникновения экземы Капоши достаточно детально рассматриваются причины нарушений  функционирования эпидермального барьера  кожи, которые способствуют более легкому проникновению вируса простого герпеса в кожу и связыванию его с клеточными рецепторами при реализации инфекционного процесса. Показано влияние системного и местного иммунитета, а именно изменений в Т-клеточном звене и системе интерферона на развитие патологического процесса.

This review presents an analysis of the literature data on the etiology and pathogenesis  of Herpetic Eczema (Kaposi's Eczema). Modern views on the complex genetic and phenotypic determinants of disease, reflecting the complex interactions between the skin and the immune system. Along with the general regularities characteristic of Herpetic Eczema in sufficient detail the reasons of infringements of functioning of the epidermal skin barrier, which contribute to an easier penetration of the Herpes Simplex  Virus in the skin and its binding  to cellular receptors in the implementation of the infectious process. The effect of systemic and local immunity, namely, changes in T-cell and interferon system in the development of the pathological process.

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The authors declare that there are no conflicts of interest present.