References

detinf

ДЕТСКИЕ ИНФЕКЦИИ

CHILDREN INFECTIONS

2072-81072618-8139

Association of Pediatricians and Infection Disease doctors

10.22627/2072-8107-2017-16-4-52-57

detinf-328

Research Article

ОБЗОР ЛИТЕРАТУРЫ

REVIEW OF THE LITERATURE

ЗНАЧЕНИЕ ВИТАМИНА D В ПАТОЛОГИИ ЧЕЛОВЕКА

THE VALUE OF VITAMIN D IN HUMAN PATHOLOGY

Скрипченко

Н. В.

Skripchenko

N. V.

д.м.н. профессор, заместитель директора по научной работе

197022, Санкт-Петербург, ул. Профессора Попова, д. 9

заведующая кафедрой

кафедра инфекционных заболеваний у детей ФП и ДПО

+7 (812) 234-10-38

MD, professor, deputy director for scientific work Pediatric Research and Clinical Center of Infectious Diseases

+7 (812) 234-10-38

snv@niidi.ru

Бухалко

М. А.

Buhalko

M. A.

аспирант, врач-инфекционист

отдел нейроинфекций и органической патологии нервной системы

197022, Санкт-Петербург, ул. Профессора Попова, д. 9

post-graduate student of the Department of Neuroinfections and Organic Pathology of the Nervous System Pediatric Research and Clinical Center of Infectious Diseases

marinabuhalko@mail.ru

Алексеева

Л. А.

Alekseeva

L. A.

дбн, ведущий научный сотрудник

отдел клинической лабораторной диагностики

197022, Санкт-Петербург, ул. Профессора Попова, д. 9 +7(812) 234-34-18,

Head of the Department of Clinical Laboratory Diagnostics Pediatric Research and Clinical Center of Infectious Diseases

+7(812) 234-34-18

kldidi@mail.ru

Скрипченко

Е. Ю.

Skripchenko

E. Ju.

ст. н.с. отдела нейроинфекций и органической патологии нервной системы

197022, Санкт-Петербург, ул. Профессора Попова, д. 9

доцент

кафедра психоневрологии

зав. детским неврологическим отделением

Associate Professor of Psychoneurology, Head of Children's Neurological Department

Pediatric Research and Clinical Center of Infectious Diseases

wwave@yandex.ru

Детский научно-клинический центр инфекционных болезней у детей ФМБА России, Санкт-Петербург; Санкт-Петербургский государственный педиатрический медицинский университет Минздрава России, Санкт-ПетербургРоссияScientific Research Institution of Children's Infectious Diseases FMBA Russian Federation, St. Petersburg; St.Petersburg State Pediatric Medical University Ministry of health Russian Federation, St. PetersburgRussian Federation

Детский научно-клинический центр инфекционных болезней у детей ФМБА России, Санкт-ПетербургРоссияScientific Research Institution of Children's Infectious Diseases FMBA Russian Federation, St. PetersburgRussian Federation

Детский научно-клинический центр инфекционных болезней у детей ФМБА России, Санкт-Петербург; Санкт-Петербургский государственный педиатрический медицинский университет Минздрава России, Санкт-Петербург; Институт мозга человека РАН им. Н.П. Бехтеревой, Санкт-ПетербургРоссияScientific Research Institution of Children's Infectious Diseases FMBA Russian Federation, St. Petersburg; St.Petersburg State Pediatric Medical University Ministry of health Russian Federation, St. Petersburg; Institution of Human Brain named after N.P. Bekhtereva Russian Academy of Science, St. PetersburgRussian Federation

2017

08122017

1645257

2017

Скрипченко Н.В., Бухалко М.А., Алексеева Л.А., Скрипченко Е.Ю.

Skripchenko N.V., Buhalko M.A., Alekseeva L.A., Skripchenko E.J.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://detinf.elpub.ru/jour/article/view/328

В обзорной статье представлены современные сведения о витамине D, его метаболизме, «классическим» и «неклассическим» функциям, которые наиболее широко изучаются в последнее время. Витамин D подавляет пролиферацию клеток и стимулирует клеточную дифференциацию, ингибирует адаптивный иммунитет и способствует врожденному иммунитету. В последние годы доказано влияние витамина D на развитие и функционирование нервной системы, включая процессы миелинизации. Эти эффекты во многом могут определять роль витамина D в профилактике и течении целого ряда широко распространенных заболеваний современного человека, включая инфекционную патологию, аутоиммунные заболевания, нервно-психические расстройства, что объясняет необходимость изучения терапевтического потенциала витамина D при различной патологии человека.

This review article presents the current data on vitamin D metabolism, «classical» and «nonclassical» functions which are most widely studied in recent years. Vitamin D inhibits cell proliferation and stimulates cell differentiation, inhibits adaptive immunity and promotes innate immunity. In recent years, proven the impact of vitamin D on the development and functioning of the nervous system, including the process of myelination. These effects can largely determine the role of vitamin D in the prevention and for a number of widespread diseases of modern man, including infectious pathology, autoimmune diseases, neuropsychiatric disorders, which explains the necessity of studying the therapeutic potential of vitamin D in a variety of human pathology.

витамин Dрецепторы витамина D«классические» и «неклассические» функции витамина D

vitamin Dvitamin D receptor«classical» and «nonclassical» functions of vitamin D

References1

Holick M.F., Binkley N.C., Bischoff-Ferrari H.A., et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011; 96(7):1911—1930.

Arash Hossein, Michael F. Holick. Vitamin D for Health: A Global Perspective. Mayo clinic proceedings. 2013; 88(7):720—755.

Pludowski P, Holick M.F., Pilz S., Wagner C.L., Hollis B.W., Grant W.B. et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence. Autoimmun Rev. 2013; 12(10):976—989.

Захарова И.Н., Яблочкова С.В., Дмитриева Ю.А. Известные и неизвестные эффекты витамина D. Вопросы современной педиатрии. 2013; 12: 2: 20—25. [Zakharova I.N., Yablochkova S.V., Dmitrieva Yu.A. Well-known and indeterminate effects of vitamin D. Voprosy Sovremennoj Pediatrii. 2013; 12: 2: 20—25. (in Russ.)].

Ramagopalan S.V., Heger A., Berlanga A.J. et al. A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution. Genome Research. 2010, 20(10): 1352—1360.

Uitterlinden A.G., Fang Y., van Meurs J.B.J., Pols H.A.P., van Leeuwen J.P.T.M. Genetics and biology of vitamin D receptor polymorphisms: Review. Gene. 2004; 338: 43—156.

Мальцева Л.И., Васильева Э.Н. Новые подходы к оценке роли витамина D в репродуктивном здоровье женщины. Практиче- ская медицина 2013. 7 (76): 42—47. [Maltseva L.I., Vasileva E.N. New approaches to assessment of the role of vitamin D in reproductive health of women. Practical Мedicine. 2013. 7(76): 42—47. (in Russ.)].

De-Regil L.M., Palacios C., Ansary A., Kulier R., Peña-Rosas J.P. Vitamin D supplementation for women during pregnancy. Rev. 2012. 15(2): 873.

Gale C.R., Robinson S.M., Harvey N.C., et al. Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr. 2008; 62(1):68—7731.

Kim B.G., Chang S.K., Kim S.M., Hwang J.S., Jung J.W. Dilated cardiomyopathy in a 2 month-old infant: a severe form of hypocalcemia with vitamin D deficient rickets. Korean Circ J. 2010; 40(4):201—203.

Lapillonne А. Vitamin D deficiency during pregnancy may impair maternal and fetal outcomes. MedHypotheses. 2010; 74(1): 71— 75.

Ma R., Gu Y., Zhao S., Sun J., Groome L.J., Wang Y. Expressions of vitamin D metabolic components VDBP, CYP2R1, CYP27B1, CYP24A1, and VDR in placentas from normal and preeclamptic pregnancies. Am J Physiol Endocrinol Metab. 2012; 303(7): 928—935.

Wei S.Q., Qi H.P., Luo Z.C., Fraser W.D. Maternal vitamin D status and adverse pregnancy outcomes: a systematic review and metaanalysis. J Matern Fetal Neonatal Med. 2013;26(9):889—899.

Maka, N., Makrakis, J., Parkington, H.C. et al. Vitamin D deficiency during pregnancy and lactation stimulates nephrogenesis in rat offspring. Pediatr Nephrol. 2008; 23: 55.

Sheng Chen, Gary P. Sims, Xiao Xiang Chen, Yue Ying Gu, Shunle Chen, Peter E. Lipsky. Modulatory Effects of 1,25-Dihydroxyvitamin D3 on Human B Cell Differentiation. The Journal of Immunology. 2007; 179:1634—1647.

Adams J.S., Hewison M. Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nat. Clin. Pract. Endocrinol. Metab. 2008; 4(2): 80—90.

Bikle D. Vitamin D and Immune Function: Understanding Common Pathways. Curr. Osteoporos. Rep. 2009; 7: 58—63.

Gombart A.F., et al. Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. FASEB J. 2005;19:1067—1077.

Yim S. et al. Induction of cathelicidin in normal and CF bronchial epithelial cells by 1,25-dihydroxyvitamin D(3). J Cyst Fibros. 2007; 6:403—410.

Elisabetta V., Ludovica F., Nuria Martinez-Alier, Vas N. Vitamin D and tuberculosis: a multicenter study in children. BMC Infectious Diseases .2014; (1):652.

Peter D., Vijayakumar J., John K.R, Joy S., Asha L. et al. Adjunctive vitamin D for treatment of active tuberculosis in India: a randomised, double-blind, placebo-controlled trial. Lancet Infect Dis. 2015; 15(5):528—34.

Tukvadze N., Sanikidze E., Kipiani M., Hebbar G., Easley K.A., Shenvi N. High-dose vitamin D3 in adults with pulmonary tuberculosis: a double-blind randomized controlled trial. Am J Clin Nutr. 2015; 102(5):1059—69.

Adrian R. M., David A. J., Richard L. H. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant. BMJ. 2017; 356:i6583.

Bergman P., Norlin A.C., Hansen S., Björkhem-Bergman L. Vitamin D3 supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study. BMC Res Notes. 2015; 30;8:391.

Camargo C.A., Ingham T., Wickens K., et al. Cord-blood 25-hydroxyvitamin D levels and risk of respiratory infection, wheezing, and asthma. Pediatrics. 2011; 127(1): 180—187.

Malcolm K., Jessica A., Natan S., Vin T. Impact of Vitamin D on Infectious Disease. The American Journal of the Medical Sciences. 2015; 349(3).

Sabetta J.R., DePetrillo P., Cipriani R.J., Smardin J., Burns L.A., Landry M.L. Serum 25-hydroxyvitamin D and the incidence of acute viral respiratory tract infections in healthy adults. PLoS One. 2010; 5(6):0011088.

Urashima M., Segawa T., Okazaki M., Kurihara M., Wada Y., Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J ClinNutr. 2010; 91(5):1255— 1260.

Nghiem X.H., Nguyen K., Mai T.B., Dao P.G. et al. Association of vitamin D deficiency with hepatitis B virus — related liver diseases. BMC Infectious Diseases. 2016; 16:507.

Yokoyama S., Takahashi Y., Kawakami C., Hayes N., Kohno H. Effect of vitamin D supplementation on pegylated interferon/ribavirin therapy for chronic hepatitis C genotype 1b: a randomized controlled trial. Journal of Viral Hepatitis. 2014; 348—356.

Visser D.H., Schoeman J.F., VAN Furth A.M. Seasonal variation in the incidence rate of tuberculous meningitis is associated with sunshine hours. Epidemiol Infect. 2013, Mar;141(3):459—62.

Tran B., Armstrong B.K., Ebeling P.R. Effect of vitamin D supplementation on antibiotic use: a randomized controlled trial. J Clin Nutr. 2014; 99:156—61.

Tachimoto H., Mezawa H., Segawa T., Akiyama N., Ida H., Urashima M. Improved control of childhood asthma with low-dose, short-term vitamin D supplementation: a randomized, double-blind, placebo-controlled trial. Allergy. 2016; 71:1001—9.

Cuiling Xu, Vicky J. Fang, Ranawaka P., Andrea May-Sin Kam and al. Serum25-Hydroxyvitamin D Was Not Associated with Influenza Virus Infection in Children and Adults in Hong Kong. J. Nutr. December 2016; 146: 2506—2512.

Helia M., Behrooz A., Farzin K., Majid Y. Association Between Acute Infectious Mononucleosis and Vitamin D Deficiency. Viral Immunology. 2016; 29(7): 398—400.

Christos K., Paraskevi T., Maria K. Vitamin D deficiency in patients with liver cirrhosis. Annals of Gastroenterology. 2016; 29, 297— 306.

Lange C.M., Bojunga J., Ramos-Lopez E, von Wagner M., Hassler A. et al. Vitamin D deficiency and a CYP27B1-1260 promoter polymorphism are associated with chronic hepatitis C and poor response to interferon-alfa based therapy. J Hepatol. 2011; 54: 887—893.

Mpandzou G., Ben Haddou E., Regragui W., Benomar A., Yahyaoui M. Vitamin D deficiency and its role in neurological conditions: A review. Rev Neurol. 2016;172(2):109—22.

Whitehouse A.J., Holt B.J., Serralha M., Holt P.G., Kusel M.M., Hart P.H. Maternal serum vitamin D levels during pregnancy and offspring neurocognitive development. Pediatrics. 2012; 129(3): 485—493.

Eyles D.W., Burne T.H., McGrath J.J. Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. Front Neuroendocrinol. 2013; 34(1):47—64.

Chabas J.-F., Delphine S., Tanguy M., Stephane G., Lavaut M.-N. Catherine Nguyen et al. Cholecalciferol (Vitamin D3) Improves Myelination and Recovery after Nerve Injury. PLOS ONE. 2013; 8(5): e65034.

Becker A., Eyles D.W., McGrath J.J., Grecksch G. Transient prenatal vitamin D deficiency is associated with subtle alterations in learning and memory functions in adult rats. Behav Brain Res. 2005; 161(2):306—31.

Föcker M., Antel J., Ring S., Hahn D., Kanal Ö., Öztürk D. et al. Vitamin D and mental health in children and adolescents. Child Adolesc Psychiatry. 2017.

O’Loan J., Eyles D.W., Kesby J., Ko P., McGrath J.J., Burne T.H. Vitamin D deficiency during various stages of pregnancy in the rat; its impact on development and behaviour in adult offspring. Psychoneuroendocrinology. 2007; 32(3):227—234.

Yu J., Gattoni-Celli M., Zhu H., et al. Vitamin D3-enriched diet correlates with a decrease of amyloid plaques in the brain of AbPP transgenic mice. J Alzheimers Dis. 2011; 25(2): 295—307.

Simon K.C., Munger K.L., Ascherio A. Vitamin D and multiple sclerosis: epidemiology, immunology, and genetics. Curr Opin Neurol. 2012; 25(3):246—251.

Pavan B., Sandra C., Sonya S., Christina A., Daniel P. E. et al. The Vitamin D to Ameliorate Multiple Sclerosis (VIDAMS) trial: Study design for a multicenter, randomized, double-blind controlled trial of vitamin D in multiple sclerosis. Contemporary Clinical Trials Communications. 2014; 288—293.

Fereshteh A., Nafiseh T., Sayyed H. Zarkesh-Esfahani, Marjan M. Short-term effect of high-dose vitamin D on the level of interleukin 10 in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled clinical trial. Neuroimmunomodulation. 2015; 22(6):400—4.

Runia T.F., Hop W.C., de Rijke Y.B., Buljevac D., Hintzen R.Q. Lower serum vitamin D levels are associated with a higher relapse risk in multiple sclerosis. Neurology. 2012; 79(3): 261—266.

Elias S. S., Pavan B., Christopher E., Van H. Safety and immunologic effects of high-vs low-dose cholecalciferol in multiple sclerosis. American Academy of Neurology. 2016; 26; 86(4):382—90.

Скрипченко Н.В., Иванова Г.П., Скрипченко Е.Ю., Суровцева А.В. Демиелинизирующие заболевания нервной системы у детей. Этиология, клиника, патогенез, диагностика, лечение. Санкт- Петербург.: Комментарий, 2016; 21—32. [Skripchenko N.V., Ivanova G.P., Skripchenko E.YU., Surovceva A.V. Demyelinating diseases of the nervous system in children. Etiology, clinic, pathogenesis, diagnostics, treatment. Sankt-Peterburg.: Publ. Kommentarij, 2016:21—32 (in Russ.)].

Judd S.E., Morgan C.J., Panwar B., Howard V.J., Wadley V.G., Jenny N.S. et al. Vitamin D deficiency and incident stroke risk in community-living black and white adults. Int J Stroke. 2016; 11(1):93— 102.

The authors declare that there are no conflicts of interest present.