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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">detinf</journal-id><journal-title-group><journal-title xml:lang="ru">ДЕТСКИЕ ИНФЕКЦИИ</journal-title><trans-title-group xml:lang="en"><trans-title>CHILDREN INFECTIONS</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-8107</issn><issn pub-type="epub">2618-8139</issn><publisher><publisher-name>Association of Pediatricians and Infection Disease doctors</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22627/2072-8107-2018-17-2-14-17</article-id><article-id custom-type="elpub" pub-id-type="custom">detinf-358</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>КЛИНИКО-ЛАБОРАТОРНАЯ ХАРАКТЕРИСТИКА КОКЛЮША У ДЕТЕЙ ПЕРВОГО ГОДА ЖИЗНИ</article-title><trans-title-group xml:lang="en"><trans-title>СLINICAL AND LABORATORY FEATURES OF PERTUSSIS IN INFANTS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крамарь</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kramar</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Крамарь Любовь Васильевна, доктор медицинских наук, профессор, заведующая кафедрой детских инфекционных болезней </p><p>400131, Волгоград, пл. Павших Борцов,1</p></bio><bio xml:lang="en"><p>Lyubov Kramar, MD, Professor, Head of the Department of Children's Infectious Diseases </p><p>Volgograd</p></bio><email xlink:type="simple">lubov-kramar@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алюшин</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Alyushin</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Главный врач ГБУЗ «Волгоградская областная детская клиническая инфекционная больница», главный внештатный детский инфекционист областного Комитета по здравоохранению Волгоградской области </p><p>Волгоград</p></bio><bio xml:lang="en"><p>Chief Physician of the Volgograd Oblast Children's Clinical Infectious Disease Hospital, chief infectious disease infectious diseases specialist of the Regional Health Committee of the Volgograd Region </p><p> </p><p>Volgograd</p></bio><email xlink:type="simple">amalyushin2012@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хлынина</surname><given-names>Ю. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Khlynina</surname><given-names>Yu. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат медицинских наук, ассистент кафедры детских инфекционных болезней</p><p>Волгоград</p></bio><bio xml:lang="en"><p>PhD, Assistant of the Department of Children's Infectious Diseases </p><p>Volgograd</p></bio><email xlink:type="simple">hlinina2013@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации<country>Россия</country></aff><aff xml:lang="en">Volgograd state medical University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ГБУЗ Волгоградская областная детская клиническая инфекционная больница<country>Россия</country></aff><aff xml:lang="en">Volgograd regional hospital of children's infectious diseases<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>30</day><month>06</month><year>2018</year></pub-date><volume>17</volume><issue>2</issue><fpage>14</fpage><lpage>17</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Крамарь Л.В., Алюшин А.М., Хлынина Ю.О., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Крамарь Л.В., Алюшин А.М., Хлынина Ю.О.</copyright-holder><copyright-holder xml:lang="en">Kramar L.V., Alyushin A.M., Khlynina Y.O.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://detinf.elpub.ru/jour/article/view/358">https://detinf.elpub.ru/jour/article/view/358</self-uri><abstract><p>Целью исследования было изучение современных особенностей коклюша у детей первого года жизни.</p><p>Проведено изучение клинического течения коклюша у 63 детей первого года жизни, проходивших лечение в Волгоградской областной детской клинической инфекционной больнице в 2015—2017 гг.</p><p>Установлено, что в настоящее время коклюш сохраняет все типичные черты заболевания. У большинства детей он протекает в среднетяжелой форме, однако у младенцев первых 3 месяцев жизни частота тяжелых форм составляет 18,7%. Пневмония у детей первого года жизни развивается в 14,3 % случаев, что указывает на более благоприятное течение заболевания в настоящее время.</p></abstract><trans-abstract xml:lang="en"><p>The aim of the investigation was to study the current features of pertussis in children of the first year of life.</p><p>The clinical course of pertussis was studied in 63 infants treated in theVolgogradregional children's infectious diseases hospital in 2015—2017.</p><p>The analysis of the obtained data demonstrated that currently pertussis retains the typical clinical and laboratory features of the disease. In most children pertussis was of moderate severity, however, in infants under 3 months of age the incidence of severe cases was 18.7 %. Pneumonia in infants developed in 14.3 % of cases, indicating a more favorable course of the pertussis at present time.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>коклюш</kwd><kwd>дети первого года жизни</kwd><kwd>клиническое течение коклюша</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pertussis</kwd><kwd>infants</kwd><kwd>clinical course of pertussis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">M. Saadatian-Elahi, S. Plotkin, K.H. Mills et al. Pertussis: Biology, epidemiology and prevention. Vaccine. 2016; 34(48):5819— 5826.</mixed-citation><mixed-citation xml:lang="en">M. Saadatian-Elahi, S. Plotkin, K.H. Mills et al. Pertussis: Biology, epidemiology and prevention. Vaccine. 2016; 34(48):5819— 5826.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Таточенко В.К. Коклюш — недоуправляемая инфекция. Вопросы современной педиатрии. 2014;13(2):78—82.</mixed-citation><mixed-citation xml:lang="en">Tatochenko V.K. Whooping cough is a nedouravelable infection. Voprosy Sovremennoy Pediatrii=Questions of Modern Pediatrics. 2014; 13 (2): 78-82. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Государственный доклад о состоянии санитарно-эпидемиологи ческого благополучия населения в Волгоградской области в 2015 году. Волгоград, Федеральная служба по надзору в сфере защиты прав потребителей и благополучия человека, 2016:189—201.</mixed-citation><mixed-citation xml:lang="en">State report on the state of sanitary and epidemiological welfare of the population in the Volgograd region in 2015. Volgograd, Federal Service for Supervision of Consumer Rights Protection and Human Welfare, 2016: 189-201. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">P. Stefanelli, G. Buttinelli, P. Vacca et al. Severe pertussis infection in infants less than 6 months of age: Clinical manifestations and molecular characterization. Hum. Vaccin. Immunother. 2017, Jan. 27:1—5.</mixed-citation><mixed-citation xml:lang="en">P. Stefanelli, G. Buttinelli, P. Vacca et al. Severe pertussis infection in infants less than 6 months of age: Clinical manifestations and molecular characterization. Hum. Vaccin. Immunother. 2017, Jan. 27:1—5.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Cherry J.D. Pertussis in young infants throughout the world. Clin. Infect. Dis. 2016; 63,S.4:119—122.</mixed-citation><mixed-citation xml:lang="en">Cherry J.D. Pertussis in young infants throughout the world. Clin. Infect. Dis. 2016; 63,S.4:119—122.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">M.S. Kazantzi, A. Prezerakou, S.N. Kalamitsou et al. Characteristics of Bordetella pertussis infection among infants and children admitted to paediatric intensive care units in Greece: A multicentre, 11-year study. J. Paediatr. Child. Health. 2017; 53(3):257—262.</mixed-citation><mixed-citation xml:lang="en">M.S. Kazantzi, A. Prezerakou, S.N. Kalamitsou et al. Characteristics of Bordetella pertussis infection among infants and children admitted to paediatric intensive care units in Greece: A multicentre, 11-year study. J. Paediatr. Child. Health. 2017; 53(3):257—262.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Lobzin Y.V. , N.V. Bakhareva. Retrospective study of the clinical epidemiological characteristics of pertussis in infants prior to their first vaccination in the Russian Federation. Infect. Dis. Ther. 2015; 4(1):113—123.</mixed-citation><mixed-citation xml:lang="en">Lobzin Y.V. , N.V. Bakhareva. Retrospective study of the clinical epidemiological characteristics of pertussis in infants prior to their first vaccination in the Russian Federation. Infect. Dis. Ther. 2015; 4(1):113—123.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Краснов В.В., Ильяненков К.Ф., Павлович Л.Р., Кузмичева М.В. Коклюш у детей первого года жизни. Детские инфекции. 2018;17(1):12—17. https://doi.org/10.22627/2072-8107-2018-17-1-12-17</mixed-citation><mixed-citation xml:lang="en">Krasnov V.V., Ilyanenkov K.F., Pavlovich L.R., Kuzmicheva M.V. Pertussis in Infants. Detskie Infektsii=Children's Infections. 2018; 17(1):12—17. (In Russ.) https://doi.org/10.22627/2072-8107-2018-17-1-12-17</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Каратаев Г.И., Л.Н. Синяшина, А.Ю. Медкова. Инсерционная инактивация оперона вирулентности в популяции персистирующих бактерий Bordetella pertussis. Генетика. 2016; 52(14):413—422.</mixed-citation><mixed-citation xml:lang="en">Karataev G.I., L.N. Sinyashina, A.Yu. Medkovа. Insertion inactivation of the virulence operon in a population of persistent Bordetella pertussis bacteria. Genetika=Genetics. 2016; 52 (14): 413—422. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Баранов А.А. [и др.] Профилактическая педиатрия: руководство для врачей. Под ред. А.А. Баранова. Москва, 2012: 691.</mixed-citation><mixed-citation xml:lang="en">Baranov A.A. et al. Preventive pediatrics: a guide for doctors. Ed. A.A. Baranov. Moscow, 2012: 691. (In Russ.)</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
