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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">detinf</journal-id><journal-title-group><journal-title xml:lang="ru">ДЕТСКИЕ ИНФЕКЦИИ</journal-title><trans-title-group xml:lang="en"><trans-title>CHILDREN INFECTIONS</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-8107</issn><issn pub-type="epub">2618-8139</issn><publisher><publisher-name>Association of Pediatricians and Infection Disease doctors</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22627/2072-8107-2019-18-1-11-16</article-id><article-id custom-type="elpub" pub-id-type="custom">detinf-401</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Клинико-эпидемиологические особенности ВГЧ-6А- и ВГЧ-6В-инфекции у детей г. Москвы</article-title><trans-title-group xml:lang="en"><trans-title>The clinical and epidemiological features of HHV-6A and HHV-6B infections in children of Moscow</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4300-2260</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лысенкова</surname><given-names>М. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Lysenkova</surname><given-names>M. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лысенкова Мария Юрьевна - кандидат биологических наук, старший научный сотрудник лаборатории эпидемиологии оппортунистических инфекций.</p></bio><bio xml:lang="en"><p>Maria Lysenkova - PhD, Senior Researcher, Laboratory of Epidemiology for Opportunistic Infections, National Research Center for Epidemiology and Microbiology</p></bio><email xlink:type="simple">happydoctor-mk@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9238-9302</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мелехина</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Melekhina</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мелёхина Елена Валериевна - кандидат медицинских наук, доцент по специальности педиатрия, старший научный сотрудник клинического отдела инфекционной патологии.</p><p>Москва</p></bio><bio xml:lang="en"><p>ElenaMebkhina</p></bio><email xlink:type="simple">e.melekhina@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3840-963X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каражас</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Karazhas</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Каражас Наталья Владимировна - доктор биологических наук, профессор, руководитель лаборатории эпидемиологии оппортунистических инфекций.</p><p>Москва</p></bio><bio xml:lang="en"><p>Natalia Karazhas</p></bio><email xlink:type="simple">karazhas@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1757-8389</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Свитич</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Svitich</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Свитич Оксана Анатольевна - член-корреспондент РАН, доктор медицинских наук, заведующий лабораторией молекулярной иммунологии.</p></bio><bio xml:lang="en"><p>OxsanaSvitich</p></bio><email xlink:type="simple">svitichoa@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5610-4314</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Веселовский</surname><given-names>П. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Veselovsky</surname><given-names>P. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Веселовский Павел Андреевич – младший научный сотрудник лаборатории эпидемиологии оппортунистических инфекций.</p><p>Москва</p></bio><bio xml:lang="en"><p>PavelVeselovsky</p></bio><email xlink:type="simple">pabloandriotti@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2083-5307</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рыбалкина</surname><given-names>Т. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Rybalkina</surname><given-names>T. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рыбалкина Татьяна Николаевна - кандидат медицинских наук, старший научный сотрудник лаборатории эпидемиологии оппортунистических инфекций/</p></bio><bio xml:lang="en"><p>TatianaRybalkina</p></bio><email xlink:type="simple">rybalkinatn@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4789-4964</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бошьян</surname><given-names>Р. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Boshyan</surname><given-names>R. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бошьян Роман Евгеньевич - кандидат биологических наук, научный сотрудник лаборатории эпидемиологии оппортунистических инфекций НИЦЭМ им. Н.Ф. Гамалеи.</p><p>Москва</p></bio><bio xml:lang="en"><p>RomanBoshyan</p></bio><email xlink:type="simple">rbrm@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4670-7151</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Косенчук</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kosenchuk</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Косенчук Валерий Владиславович - лаборант-исследователь лаборатории эпидемиологии оппортунистических инфекций НИЦЭМ им. Н.Ф. Гамалеи.</p></bio><bio xml:lang="en"><p>ValeryKosenchuk</p></bio><email xlink:type="simple">ryk357@gmail.com</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2269-2533</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Музыка</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Muzyka</surname><given-names>A. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Музыка Анна Драгиевна - младший научный сотрудник клинического отдела инфекционной патологии.</p><p>Москва</p></bio><bio xml:lang="en"><p>AnnaMusikа</p></bio><email xlink:type="simple">nikolitch-anna@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9257-0171</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горелов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gorelov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Горелов Александр Васильевич - член-корреспондент РАН, доктор медицинских наук, профессор, руководитель клинического отдела инфекционной патологии.</p><p>Москва</p></bio><bio xml:lang="en"><p>Alexandr Gorelov</p></bio><email xlink:type="simple">crie@pcr.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5232-7337</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Усенко</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Usenko</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Усенко Денис Валерьевич - доктор медицинских наук, профессор, ведущий научный сотрудник клинического отдела инфекционной патологии.</p></bio><bio xml:lang="en"><p>DenisUsenko</p></bio><email xlink:type="simple">dusenko@rambler.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7696-9809</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванова</surname><given-names>М. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanova</surname><given-names>M. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иванова Марина Юрьевна - доцент кафедры гистологии, цитологии и эмбриологии</p><p>Москва</p></bio><bio xml:lang="en"><p>MarinaIvanova</p></bio><email xlink:type="simple">ivanova_m_y@mail.ru</email><xref ref-type="aff" rid="aff-6"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБУ Национальный исследовательский центр эпидемиологии и микробиологии им. почетного академика Н.Ф. Гамалеи Минздрава России<country>Россия</country></aff><aff xml:lang="en">Federal State Institution National Research Center for Epidemiology and Microbiology named after the N.F. Gamaleya of the Ministry of Health of the Russian Federation<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ФБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора<country>Россия</country></aff><aff xml:lang="en">Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">ФГБНУ Научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова<country>Россия</country></aff><aff xml:lang="en">Mechnikov Research Institute of Vaccines and Serums<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru">ФГБУ «НИЦЭМ им. Н.Ф. Гамалеи» Минздрава России; ГБОУ ВПО Первый МгМу им. И.М. Сеченова Минздрава России<country>Россия</country></aff><aff xml:lang="en">Federal State Institution National Research Center for Epidemiology and Microbiology named after the N.F. Gamaleya of the Ministry of Health of the Russian Federation<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru">ФГБУ «НИЦЭМ им. Н.Ф. Гамалеи» Минздрава России; ГБОУ ВПО Первый МгМу им. И.М. Сеченова Минздрава России<country>Россия</country></aff><aff xml:lang="en">Federal State Institution National Research Center for Epidemiology and Microbiology named after the N.F. Gamaleya of the Ministry of Health of the Russian Federation; First Moscow State Medical University named after I.M. Sechenov Ministry of Health of Russia<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru">ГБОУ ВПО Первый МгМу им. И.М. Сеченова Минздрава России<country>Россия</country></aff><aff xml:lang="en">First Moscow State Medical University named after I.M. Sechenov Ministry of Health of Russia<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>05</day><month>04</month><year>2019</year></pub-date><volume>18</volume><issue>1</issue><fpage>11</fpage><lpage>16</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лысенкова М.Ю., Мелехина Е.В., Каражас Н.В., Свитич О.А., Веселовский П.А., Рыбалкина Т.Н., Бошьян Р.Е., Косенчук В.В., Музыка А.Д., Горелов А.В., Усенко Д.В., Иванова М.Ю., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Лысенкова М.Ю., Мелехина Е.В., Каражас Н.В., Свитич О.А., Веселовский П.А., Рыбалкина Т.Н., Бошьян Р.Е., Косенчук В.В., Музыка А.Д., Горелов А.В., Усенко Д.В., Иванова М.Ю.</copyright-holder><copyright-holder xml:lang="en">Lysenkova M.Y., Melekhina E.V., Karazhas N.V., Svitich O.A., Veselovsky P.A., Rybalkina T.N., Boshyan R.E., Kosenchuk V.V., Muzyka A.D., Gorelov A.V., Usenko D.V., Ivanova M.Y.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://detinf.elpub.ru/jour/article/view/401">https://detinf.elpub.ru/jour/article/view/401</self-uri><abstract><p>Вирус герпеса человека 6 типа (ВГЧ-6) является этиологическим агентом множества заболеваний. Форма развивающейся патологии зависит от локализации вируса в T-лимфоцитах и от его типа: ВГЧ-6А или ВГЧ-6В, но идентификация типа возможна только по нуклеотидной последовательности. В России типирование ВГЧ-6 проводится в основном в Москве и Санкт-Петербурге. Особый интерес вызывает распространенность ВГЧ-6А и ВГЧ-6В среди различных групп населения.</p></abstract><trans-abstract xml:lang="en"><p>Human herpes virus type 6 (HHV-6) is the etiological agent of plenty diseases. The form of the developing pathology depends on the localization of the virus in T-lymphocytes and on virus type: HHV-6A or HHV-6B, but identification of the type is possible by nucleotide sequence only. In Russia, researching on the typing of HHV-6 are conducted in Moscow and St. Petersburg mainly, but results is discordant. Also the prevalence of HHV-6A and HHV-6B among various population groups is of particular interest.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>вирус герпеса человека 6-го типа</kwd><kwd>ВГЧ-6А</kwd><kwd>ВГЧ-6В</kwd><kwd>типирование</kwd></kwd-group><kwd-group xml:lang="en"><kwd>human herpesvirus type 6</kwd><kwd>HHV-6A</kwd><kwd>HHV-6B</kwd><kwd>typing</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Pantry S.N., Medveczky P.G. Latency, Integration, and Reactivation of Human Herpesvirus-6. Viruses. 2017 Jul; 9(7): 1 94.</mixed-citation><mixed-citation xml:lang="en">Pantry S.N., Medveczky P.G. Latency, Integration, and Reactivation of Human Herpesvirus-6. Viruses. 2017 Jul; 9(7): 1 94.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Morissette G., Flamand L. Herpesviruses and chromosomal integration. J. Virol., 2010. 84(23):12100—12109.</mixed-citation><mixed-citation xml:lang="en">Morissette G., Flamand L. Herpesviruses and chromosomal integration. J. Virol., 2010. 84(23):12100—12109.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Arbuckle J.H., Medveczky P.G. The molecular biology of human herpesvirus-6 latency and telomere integration. Microbes Infect., 2011. 13(9): 731—741.</mixed-citation><mixed-citation xml:lang="en">Arbuckle J.H., Medveczky P.G. The molecular biology of human herpesvirus-6 latency and telomere integration. Microbes Infect., 2011. 13(9): 731—741.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Мелехина Е.В., Домонова Э.А.,Сильвейстрова О.Ю., Гоптарь И.А., Кулешов К.В., Никифорова А.В., Музыка А.Д., Шипули-на О.Ю., Горелов А.В. Первый российский опыт выявления наследственной передачи хромосомно-интегрированного вируса герпеса человека 6В от отца сыну и дочери (Москва, 2017). Материалы XVII Конгресса детских инфекционистов России «Актуальные вопросы инфекционной патологии и вакцинопрофилактики». Москва, 2018, 12—14 декабря. Детские инфекции. 2018;17(1S):72.</mixed-citation><mixed-citation xml:lang="en">Melekhina E.V., Domonova E.A., Silveystrova O.Yu., Goptar I.A., Kuleshov K.V, Nikiforova A.V, Muzyka A.D., Shipulina O.Yu., Gorelov A^. The first Russian experience in identifying the hereditary transmission of a chromosomally integrated herpes virus of human 6B from father to son and daughter (Moscow, 2017). Proceedings of the XVII Congress of Pediatric Infectious Diseases of Russia. Actual Issues of Infectious Pathology and Vaccine Prevention. Moscow, 2018, December 12—14. Detskiye Infektsii=Children's Infections. 201 8; 17 (1S): 72. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Rizzo R., Bortolotti D., Gentili V, Rotola A., Bolzani S., Caselli E., Tola M.R., Di Luca D. KIR2DS2/KIR2DL2/HLA-C1 Haplotype Is Associated with Alzheimer's Disease: Implication for the Role of Herpesvirus Infections. Journal of Alzheimer’s Disease, 2019. 67(4):1 379—1 389. DOI: 10.3233/JAD-180777.</mixed-citation><mixed-citation xml:lang="en">Rizzo R., Bortolotti D., Gentili V, Rotola A., Bolzani S., Caselli E., Tola M.R., Di Luca D. KIR2DS2/KIR2DL2/HLA-C1 Haplotype Is Associated with Alzheimer's Disease: Implication for the Role of Herpesvirus Infections. Journal of Alzheimer’s Disease, 2019. 67(4):1 379—1 389. DOI: 10.3233/JAD-180777.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Onda M., Niimi Y, Ozawa K., Shiraki I., Mochizuki K., Yamamoto T., Sugita S., Ishida K. Human Herpesvirus-6 corneal Endotheliitis after intravitreal injection of Ranibizumab. BMC Ophthalmology, 2019, 19:19.</mixed-citation><mixed-citation xml:lang="en">Onda M., Niimi Y, Ozawa K., Shiraki I., Mochizuki K., Yamamoto T., Sugita S., Ishida K. Human Herpesvirus-6 corneal Endotheliitis after intravitreal injection of Ranibizumab. BMC Ophthalmology, 2019, 19:19.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ptaszynska-Sarosiek I., Dunaj J., Zajkowska A., Niemcunowicz-Janica A., Krol M., Pancewicz S., Zajkowska J. Post-mortem detection of six human herpesviruses (HSV-1, HSV-2, VZV, EBV, CMV, HHV-6) in trigeminal and facial nerve ganglia by PCR. Journal of Life and Environmental Sciences, 2019 Jan 9; 6:e6095.</mixed-citation><mixed-citation xml:lang="en">Ptaszynska-Sarosiek I., Dunaj J., Zajkowska A., Niemcunowicz-Janica A., Krol M., Pancewicz S., Zajkowska J. Post-mortem detection of six human herpesviruses (HSV-1, HSV-2, VZV, EBV, CMV, HHV-6) in trigeminal and facial nerve ganglia by PCR. Journal of Life and Environmental Sciences, 2019 Jan 9; 6:e6095.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
