<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">detinf</journal-id><journal-title-group><journal-title xml:lang="ru">ДЕТСКИЕ ИНФЕКЦИИ</journal-title><trans-title-group xml:lang="en"><trans-title>CHILDREN INFECTIONS</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-8107</issn><issn pub-type="epub">2618-8139</issn><publisher><publisher-name>Association of Pediatricians and Infection Disease doctors</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22627/2072-8107-2019-18-2-68-70</article-id><article-id custom-type="elpub" pub-id-type="custom">detinf-429</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СЛУЧАЙ ИЗ ПРАКТИКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CASE FROM PRACTICAL</subject></subj-group></article-categories><title-group><article-title>Туляремия у детей</article-title><trans-title-group xml:lang="en"><trans-title>Tularemia in children</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7587-3437</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Утенкова</surname><given-names>Е. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Utenkova</surname><given-names>E. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Утенкова Елена Олеговна - доктор медицинских наук, профессор кафедры инфекционных болезней.</p><p>Киров.</p></bio><bio xml:lang="en"><p>Elena Utenkova - MD, Professor of the Department of Infectious Diseases.</p><p>Kirov.</p></bio><email xlink:type="simple">utelol@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малкова</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Malkova</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Малкова Лариса Викторовна - заведующая диагностическим отделением.</p><p>Киров.</p></bio><bio xml:lang="en"><p>Larisa Malkova - head of diagnostic Department.</p><p>Kirov.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Кировский государственный медицинский университет<country>Россия</country></aff><aff xml:lang="en">Kirov State Medical University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Инфекционная клиническая больница<country>Россия</country></aff><aff xml:lang="en">Infectious clinical hospital<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>03</day><month>07</month><year>2019</year></pub-date><volume>18</volume><issue>2</issue><fpage>68</fpage><lpage>70</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Утенкова Е.О., Малкова Л.В., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Утенкова Е.О., Малкова Л.В.</copyright-holder><copyright-holder xml:lang="en">Utenkova E.O., Malkova L.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://detinf.elpub.ru/jour/article/view/429">https://detinf.elpub.ru/jour/article/view/429</self-uri><abstract><p>По данным российской статистики, среди больных туляремией дети составляют 15%. Между тем, в доступной литературе описания туляремии у детей практически не встречается. В статье приводятся два клинических примера туляремии у детей разного возраста.</p><p>У ребенка в возрасте 2-х лет с ульцеро-гландулярной формой отмечался первичный аффект, фебрильная лихорадка в течении недели, регионарный лимфаденит, воспалительные изменения в общем анализе крови. У второго  ребенка в возрасте 8 лет с гландулярной формой отмечалось болезненное увеличение пахового лимфоузла справа до 4 см без первичного аффекта, фебрильная лихорадка в течении недели. Диагноз туляремии подтвержден в обоих случаях серологически в РА на 19-й и 6-й дни болезни соответственно.</p><p>Диагноз туляремии вызвал затруднение у врачей разных специальностей (педиатра, хирурга), что не позволило своевременно назначить лечение. Этиотропным препаратом был амикацин.</p></abstract><trans-abstract xml:lang="en"><p>Among patients  with tularemia in Russia, children make up 15%. In the available literature, the description of tularemia in children is practically not found. The article provides two clinical examples of tularemia in children of different ages.</p><p>A child aged 2 years with an ulcero-glandular  form had a primary affect, febrile fever for a week, regional lymphadenitis, inflammatory changes in the general blood test. The second child at the age of 8 years with a glandular form had a painful increase in the inguinal lymph node to the right, up to 4 cm without primary affect, febrile fever during the week. The diagnosis of tularemia was confirmed in both cases serologically  in the agglutination  test on the 19th and 6th days of the disease, respectively.</p><p>The diagnosis of tularemia caused difficulties for doctors of different specialties (pediatrician, surgeon), which did not allow for the timely appointment of treatment. Etiotropic drug was amikacin.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>туляремия</kwd><kwd>дети</kwd><kwd>лимфадениты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>tularemia</kwd><kwd>children</kwd><kwd>lymphadenitis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">European Centre for Disease Prevention and Control. Annual Epidemiological Report 2016. Tularaemia. [Internet]. Stockholm: ECDC; 2016. Available from: http://ecdc.europa.eu/en/healthtopics/tularaemia/Pages/Annualepidemiologicalreport2016.aspx</mixed-citation><mixed-citation xml:lang="en">European Centre for Disease Prevention and Control. Annual Epidemiological Report 2016.  Tularaemia. [Internet]. Stockholm: ECDC; 2016. Available from: http://ecdc.europa.eu/en/healthtopics/tularaemia/Pages/Annualepidemiologicalreport2016.aspx</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Cross A.R.et al., Zoonoses under our noses, Microbes and Infection (2018), https://doi.org/10.1016/j.micinf.2018.06.001</mixed-citation><mixed-citation xml:lang="en">Cross A.R.et al., Zoonoses under our noses, Microbes and Infection (2018), https://doi.org/10.1016/j.micinf.2018.06.001</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Rydén P., Sjöstedt A &amp; Johansson A. Effects of climate change on tularaemia disease activity in Sweden. Global Health Action. 2009; 2:1, 2063, DOI: 10.3402/gha.v2i0.2063</mixed-citation><mixed-citation xml:lang="en">Rydén P., Sjöstedt A &amp; Johansson  A. Effects of climate change on tularaemia disease activity in Sweden. Global Health Action. 2009; 2: 1, 2063,  DOI: 10.3402/gha.v2i0.2063</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Şaban Gürcan Epidemiology of Tularemia. Balkan. Med. J. 2014; 31: 3—10.</mixed-citation><mixed-citation xml:lang="en">Şaban Gürcan Epidemiology of Tularemia. Balkan. Med. J. 2014; 31: 3—10.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Kumar R., Mansour M., Brunetto J. et al. Difficulty in the Clinical Diagnosis of Tularemia: Highlighting the Importance of a Physical Exam. Case Reports in Pediatrics. 2018, Article ID 9682815, 4 pages https://doi.org/10.1155/2018/9682815</mixed-citation><mixed-citation xml:lang="en">Kumar R., Mansour M., Brunetto  J. et al. Difficulty in the Clinical Diagnosis of Tularemia: Highlighting the Importance of a Physical Exam. Case Reports in Pediatrics.  2018,   Article  ID  9682815, 4 pages https://doi.org/10.1155/2018/9682815</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Кудрявцева Т.Ю., Попов В.П, Мокриевич А.Н., Мазепа А.В, Окунев Л.П., Холин А.В., Куликалова Е.С., Храмов М.В., Дятлов И.А., Транквилевский Д.В. Эпидемиологический и эпизоотологический анализ ситуации по туляремии в Российской Федерации в 2016 г., прогноз на 2017 г. Пробл. особо опасных инф. 2017; 2: 13—18: DOI: 10.21055/0370-1069-2017-2-13-18</mixed-citation><mixed-citation xml:lang="en">Kudryavceva T.Yu.,  Popov  V.P,  Mokrievich  A.N., Mazepa  A.V, Okunev L.P., Holin A.V., Kulikalova Е.S., Hramov M.V., Dyatlov I.A., Trankvilevskij D.V. Epidemiological and epizootological analysis of the situation on tularemia in the Russian Federation in 2016,  the forecast  for  2017.  Problemy  Osobo  Opasnykh Infektsiy.  2017; 2:13—18. (In Russ.). DOI: 10.21055/0370-1069-2017-2-13-18</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Русев И.Т., Закусило В.Н. Эпидемические вспышки и эпизоотии туляремии, как последствия авиационных бомбардировок в Косове. Вестник Днепропетровского Университета. Биология. Медицина. 2012; 3(2):71—80.</mixed-citation><mixed-citation xml:lang="en">Rusev I.T., Zakusilo V.N. Epidemic outbreaks and tularemia epizootics, as the consequences of aerial bombardment in Kosovo. Vestnik Dnepropetrovskogo Universiteta. Biologija. Medicina. 2012; 3 (2): 71—80. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Hasan Tezer, Aslınur Ozkaya-Parlakay, Hakan Aykan, Mustafa Erkocoglu, Belgin Gülhan, Ahmet Demir, Saliha Kanik-Yuksek, Anil Tapisiz, Meltem Polat, Soner Kara, Ilker Devrim, and Selcuk Kilic. Tularemia in Children, Turkey. September 2009 — November 2012. Emerging Infectious Diseases. 2015; 21(1):1—7: DOI: http://dx.doi.org/10.3201/eid2101.131127</mixed-citation><mixed-citation xml:lang="en">Hasan Tezer, Aslınur  Ozkaya-Parlakay, Hakan Aykan, Mustafa Erkocoglu, Belgin Gülhan, Ahmet Demir, Saliha Kanik-Yuksek, Anil Tapisiz, Meltem Polat, Soner Kara, Ilker Devrim, and Selcuk Kilic. Tularemia  in  Children, Turkey.   September  2009   — November 2012. Emerging Infectious Diseases. 2015;21(1):1—7: DOI: http://dx.doi.org/10.3201/eid2101.131127</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Anand N., Deochand O., Murphy R. Imaging Findings of Ulceroglandular Tularemia. Radiology Case. 2017; 11(1):1—6: DOI: 10.3941/jrcr.v11i1.2983</mixed-citation><mixed-citation xml:lang="en">Anand N., Deochand O., Murphy  R. Imaging  Findings of Ulceroglandular Tularemia. Radiology Case. 2017; 11(1):1—6: DOI: 10.3941/jrcr.v11i1.2983</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Демидова Т.Н, Попов В.П., Орлов Д.С., Михайлова Т.В., Мещерякова И.С. Современная эпидемиологическая ситуация по туляремии в Северо-Западном федеральном округе России. Эпидемиология и Вакцинопрофилактика. 2016; 5(90):14—23.</mixed-citation><mixed-citation xml:lang="en">Demidova T.N, Popov V.P., Orlov D.S., Mihajlova T.V., Meshcheryakova I.S. The current epidemiological situation on tularemia in the North-West Federal District of Russia. Epidemiologiya i Vakcinoprofilaktika. 2016; 5(90):14—23. (In Russ.)</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
