<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">detinf</journal-id><journal-title-group><journal-title xml:lang="ru">ДЕТСКИЕ ИНФЕКЦИИ</journal-title><trans-title-group xml:lang="en"><trans-title>CHILDREN INFECTIONS</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-8107</issn><issn pub-type="epub">2618-8139</issn><publisher><publisher-name>Association of Pediatricians and Infection Disease doctors</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22627/2072-8107-2021-20-2-16-21</article-id><article-id custom-type="elpub" pub-id-type="custom">detinf-592</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Клинические особенности течения риновирусной инфекции у детей</article-title><trans-title-group xml:lang="en"><trans-title>Clinical features of the course of Rhinoviral infection in children</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1772-5978</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Попова</surname><given-names>О. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Popova</surname><given-names>O. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Попова Ольга Петровна - доктор медицинских наук, профессор кафедры детских инфекционных болезней.</p><p>Москва</p></bio><bio xml:lang="en"><p>Olga Popova, MD, Professor.</p><p>Moscow</p></bio><email xlink:type="simple">doctorpopova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1656-3716</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вартанян</surname><given-names>Р. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vartanyan</surname><given-names>R. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Вартанян Раиса Викторовна - кандидат медицинских наук, ведущий научный сотрудник лаборатории острых респираторных вирусных инфекций с апробацией лекарственных препаратов Москва</p></bio><bio xml:lang="en"><p>Raisa Vartanyan, PhD.</p><p>Moscow</p></bio><email xlink:type="simple">immunol.lab@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9610-3041</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трушакова</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Trushakova</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Трушакова Светлана Викторовна - кандидат биологических наук, старший научный сотрудник.</p><p>Москва</p></bio><bio xml:lang="en"><p>Svetlana Trushakova, PhD.</p><p>Moscow</p></bio><email xlink:type="simple">s.trushakova@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7474-6292</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бунин</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bunin</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бунин Сергей Валерьевич - заведующий 3-м педиатрическим отделением.</p><p>Москва</p></bio><bio xml:lang="en"><p>Sergey Bunin</p><p>Moscow</p></bio><email xlink:type="simple">bunin_sergey72@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7557-2236</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Драчева</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Dracheva</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Драчева Наталья Алексеевна - аспирант кафедры детских инфекционных болезней.</p><p>Москва</p></bio><bio xml:lang="en"><p>Natalia Dracheva</p><p>Moscow</p></bio><email xlink:type="simple">tan1809@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБОУ ДПО Российская медицинская академия непрерывного профессионального образования Министерства Российской Федерации<country>Россия</country></aff><aff xml:lang="en">Russian Medical Academy of Continuing Professional Education of the Ministry of the Russian Federation<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ФГБУ Национальный исследовательский центр эпидемиологии и микробиологии (НИЦЭМ) им. Н.Ф. Гамалеи Минздрава России<country>Россия</country></aff><aff xml:lang="en">National Research Center for Epidemiology and Microbiology them. N.F. Gamaleys of the Ministry of Health of Russia<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">ГБУЗ Инфекционная клиническая больница №1 ДЗМ<country>Россия</country></aff><aff xml:lang="en">Infectious Clinical Hospital No.1<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>07</day><month>07</month><year>2021</year></pub-date><volume>20</volume><issue>2</issue><fpage>16</fpage><lpage>21</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Попова О.П., Вартанян Р.В., Трушакова С.В., Бунин С.В., Драчева Н.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Попова О.П., Вартанян Р.В., Трушакова С.В., Бунин С.В., Драчева Н.А.</copyright-holder><copyright-holder xml:lang="en">Popova O.P., Vartanyan R.V., Trushakova S.V., Bunin S.V., Dracheva N.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://detinf.elpub.ru/jour/article/view/592">https://detinf.elpub.ru/jour/article/view/592</self-uri><abstract><p>Острые респираторные вирусные инфекции остаются наиболее распространенными заболеваниями в мире, составляя около 90% всей инфекционной патологии. Возможности этиологической расшифровки ОРВИ с применением современных методов обследования позволили установить увеличение доли риновирусной инфекции в структуре ОРВИ.</p><p>Целью исследования явилось изучение особенностей клинического течения риновирусной инфекции у детей различного возраста в современных условиях.</p><p>Под наблюдением находилось 50 детей с риновирусной инфекцией: 12 детей (24%) были в возрасте до 1 года; 34 ребенка (68%) — 1 —3 лет, 4 ребенка (8%) — 3—7 лет. Для подтверждения риновирусной инфекции проводилось исследование слизи из носоглотки методом ПЦР.</p><p>Тщательный анализ симптомокомплекса инфекции показал, что только у 13 (26%) больных инфекционный процесс ограничивался поражениями верхних дыхательных путей, у 14 (28%) отмечались явления острого стенозирующего ларинготрахеита, у 1 1 (22%) детей развивались пневмонии, у 12 (24%) — бронхиты, причём с обструктивным синдромом у 1 0 (83,3%) пациентов в этой группе.</p></abstract><trans-abstract xml:lang="en"><p>Acute respiratory viral infections remain the most common diseases in the world, accounting for about 90% of all infectious diseases. The possibilities of etiological decoding of ARVI using modern examination methods made it possible to establish an increase in the proportion of rhinovirus infection in the structure of ARVI.</p><p>The aim of the study in this regard was to study the features of the clinical course of rhinovirus infection in children of different ages in modern conditions. The study included 50 patients with rhinovirus infection of children, among whom 1 2 children (24%) were under 1 year old; 34 children (68%) — 1—3 years old, 4 children (8%) — 3—7 years old. To confirm rhinovirus infection, a study of mucus from the nasopharynx by PCR was carried out.</p><p>A thorough analysis of the symptom complex of the infection showed that in 1 3 (26%) patients the infectious process was limited to lesions of the upper respiratory tract, in 14 (28%) there were symptoms of acute stenosinglaryngotracheitis, in 1 1 (22%) children developed pneumonia, in 1 2 (24%) — bronchitis, with obstructive syndrome in 1 0 (83.3%) patients in this group.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>риновирусная инфекция</kwd><kwd>дети</kwd><kwd>стенозирующий ларинготрахеит</kwd><kwd>бронхит</kwd><kwd>пневмония</kwd></kwd-group><kwd-group xml:lang="en"><kwd>rhinovirus infection</kwd><kwd>children</kwd><kwd>stenosinglaryngotracheitis</kwd><kwd>bronchitis</kwd><kwd>pneumonia</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Шамшева О.В. Грипп и ОРВИ у детей. М.: ГЭОТАР-Медиа, 2018:112.</mixed-citation><mixed-citation xml:lang="en">Shamsheva O.V Influenza and SARS in children. M.: GEOTAR-Media, 2018:1 12. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Инфекционные болезни у детей. Руководство для врачей — 2-е издание переработанное и дополненное. Под ред. В.В. Ивановой. М.: ООО «МИА», 2009:832.</mixed-citation><mixed-citation xml:lang="en">Infectious diseases in children. Guide for doctors-2nd edition revised and expanded. Ed. by V.V. Ivanova. M.: LLC «MIA», 2009:832. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Грекова А.И. [и др.]. Анализ ОРВИ у детей Смоленской области за 2015—201 9 гг.: Материалы XIX Конгресса детских инфекционистов России. Актуальные вопросы инфекционной патологии и вакцинопрофилактики. Детские инфекции. 2020; 19(1S):41—43.https://doi.org/10.22627/2072-8107-2020-18-1S</mixed-citation><mixed-citation xml:lang="en">Grekova A. I. [et al.]. Analysis of SARS in children Smolensk region for 2015—201 9: Materials of the XIX Congress of Children's Infectious Diseases of Russia «Topical issues of infectious pathology and vaccine prevention». Detskie Infektsii=Children's Infections. 2020; 19(1S):41—43. (In Russ.) https://doi.org/10.22627/2072-8107-2020-18-1S</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Николаева С.В. [и др.]. Эволюция острых респираторных вирусных инфекций сочетанной этиологии у детей. РМЖ, 2020; (12):66—68.</mixed-citation><mixed-citation xml:lang="en">Nikolaevа S. V [et al.]. Evolution of acute respiratory viral infections associated etiology in determi. RMJ, 2020; (12):66—68. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Исаева Е.И. [и др.]. Этиологическая структура заболеваемости ОРВИ у взрослых и детей. Инфекция и иммунитет: Материалы X съезда ВНПОЭМП, 2012; (2):396.</mixed-citation><mixed-citation xml:lang="en">Isaeva E. I. [et al.]. Etiological structure of SARS morbidity in adults and children. Infection and immunity. Proceedings of the X Congress of VNPOEMP, 2012; (2): 396. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">PAULA, Nayhanne Tizzo [et al.]. Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent. Mem. Inst. Oswaldo Cruz. 2011, №3(106):316—321.</mixed-citation><mixed-citation xml:lang="en">PAULA, Nayhanne Tizzo [et al.]. Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent. Mem. Inst. Oswaldo Cruz. 2011, №3(106):316—321.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Макарова А.В. [и др.]. Риновирусная инфекция у детей. Прикладные информационные аспекты медицины, 2019; №22(4):8—11.</mixed-citation><mixed-citation xml:lang="en">Makarova A.V. [et al.]. Rhinovirus infection in children. Prikladnyye Informatsionnyye Aspekty Meditsiny, 2019; №22(4):8—11. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Sai-Zhen Zeng [et al.]. Prevalence of human rhinovirus in children ad mitted to hospital with acute lower respiratory tract infections in Changsha. China. J. Med. Virol, 2014:86(11).</mixed-citation><mixed-citation xml:lang="en">Sai-Zhen Zeng [et al.]. Prevalence of human rhinovirus in children ad mitted to hospital with acute lower respiratory tract infections in Changsha. China. J. Med. Virol, 2014:86(11).</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Stephanie M. Warner [et al.]. Rhinovirus replication and innate immunity in highly differentiated human airway epithelial cells. J. Respu Res, 2019; 20(1):150.</mixed-citation><mixed-citation xml:lang="en">Stephanie M. Warner [et al.]. Rhinovirus replication and innate immunity in highly differentiated human airway epithelial cells. J. Respu Res, 2019; 20(1):150.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Осидак Л.В. Острые респираторные вирусные инфекции: практическое руководство для врачей. СПб.: «Информ Мед», 2010:216.</mixed-citation><mixed-citation xml:lang="en">Osidak L.V. Acute respiratory infections in children and adolescents: a practical guide for doctors. Sankt-Peterburg: «Inform Med», 2010:216. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Midulla F. [et al.]. Respiratorysyncytialvirus, human bocavirus and rhinovirus bronchiolit is in infants. Arch Dis Child, 2010; 95(1):35— 41.</mixed-citation><mixed-citation xml:lang="en">Midulla F. [et al.]. Respiratorysyncytialvirus, human bocavirus and rhinovirus bronchiolit is in infants. Arch Dis Child, 2010; 95(1):35— 41.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Хаитов М.Р. [и др.]. Риновирусная инфекция при атопической бронхиальной астме у детей. Российский аллергологический журнал, 2004; 1 (30):6.</mixed-citation><mixed-citation xml:lang="en">Khaitov M. R. [et al.]. Rhinovirus infection in atopic bronchial asthma in children. Rossiyskiy Аllergologicheskiy Zhurnal=Russian Aller-gologicalJournal, 2004; 1(30):6. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Ferreira A. [et al.]. Rhinovirus is associated withsevere asthma exacerbations and raised nasal interleukin-12. Respiration, 2002; 69:136-42.</mixed-citation><mixed-citation xml:lang="en">Ferreira A. [et al.]. Rhinovirus is associated withsevere asthma exacerbations and raised nasal interleukin-12. Respiration, 2002; 69:136-42.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
