detinfДЕТСКИЕ ИНФЕКЦИИCHILDREN INFECTIONS2072-81072618-8139Association of Pediatricians and Infection Disease doctors10.22627/2072-8107-2021-20-2-33-37detinf-595Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESПренатальная антибиотикотерапия как фактор риска неонатального некротизирующего энтероколитаPrenatal antibiotic therapy as a risk factor for Neonatal Necrotizing Enterocolitishttps://orcid.org/0000-0002-4634-3696БочковаЛ. Г.BochkovaL. G.

Бочкова Лариса Геннадьевна - кандидат медицинских наук, доцент кафедры госпитальной педиатрии и неонатологии

Larisa Bochkova, PhD, Associate Professor

Lu_lg@mail.ruhttps://orcid.org/0000-0002-5663-9220ЭйберманА. С.EibermanA. S.

Эйберман Александр Семенович - доктор медицинских наук, профессор кафедры госпитальной педиатрии и неонатологии

Alexander Eiberman, MD, Professor

aberman@bk.ruhttps://orcid.org/0000-0002-6896-7563ЧерненковЮ. В.ChernenkovY. V.

Черненков Юрий Валентинович - доктор медицинских наук, профессор, заведующий кафедрой госпитальной педиатрии и неонатологии

Yuriy Chernenkov, MD, Professor

chernenkov64@mail.ruКирилочевО. К.KirilochevO. K.

Кирилочев Олег Константинович - доктор медицинских наук, доцент, профессор кафедры анестезиологии и реаниматологии

Oleg Konstantinovich, MD, Associate Professor

kirilochevoleg@gmail.comФГБОУ ВПО Саратовский государственный медицинский университет им. В.И. Разумовского Министерства здравоохранения Российской ФедерацииРоссияSaratov State Medical University of V.I. RazumovskyRussian FederationАстраханский государственный медицинский университет Министерства здравоохранения Российской ФедерацииРоссияAstrakhan State Medical UniversityRussian Federation2021070720212023337Copyright © Бочкова Л.Г., Эйберман А.С., Черненков Ю.В., Кирилочев О.К., 20212021Бочкова Л.Г., Эйберман А.С., Черненков Ю.В., Кирилочев О.К.Bochkova L.G., Eiberman A.S., Chernenkov Y.V., Kirilochev O.K.This work is licensed under a Creative Commons Attribution 4.0 License.https://detinf.elpub.ru/jour/article/view/595

Целью данного исследования было определение наличия связи между пренатальным воздействием антибиотиков и заболеваемостью некротизирующим энтероколитом (НЭК) у младенцев с низкой массой тела при рождении.

Материалы и методы

Материалы и методы: проведено ретроспективное исследование «случай-контроль» у 97 младенцев с диагнозом НЭК, родившихся за период с 2010 по 2020 гг. Были проанализированы истории болезни всех младенцев с диагнозом НЭК ≥ Белла IIA стадии и сопоставимой контрольной группы. Характеристики матери и новорожденного сравнивались с использованием метода Кохра-на-Мантеля-Хензеля и модели логистической регрессии с учетом потенциальных факторов влияния.

Результаты

Результаты. Проанализированы клинические данные для 97 подобранных пар мать — ребёнок. Скорректированное отношение шансов (ОШ) для пренатального воздействия ампициллина было значительно больше у младенцев с НЭК (ОШ 2,3, 95% доверительный интервал 1,1, 4,8, P = 0,003), чем для младенцев из группы сравнения. Младенцы, у которых развился НЭК, с большей вероятностью имели в анамнезе внутриутробное воздействие ампициллина, чем младенцы без НЭК.

The aim of this study was to determine whether there is an association between antenatal antibi-otic exposure and the incidence of necrotizing enterocolitis (NEC) in low birth weight infants.

Study design

Study design: A retrospective case-control study was conducted on all infants with NEC who were born between 201 0 and 2020. Medical histories of all infants diagnosed with NEC ≥ Bella IIA stage and corresponding controls without NEC were examined. Maternal and newborn char-acteristics were compared using the Cochran-Mantel-Haenszel method, and logistic regression models were constructed to account for bias.

Results

Results. Clinical data were analyzed for 97 matched pairs. The adjusted odds ratio (OR) for pre-natal ampicillin exposure was significantly higher for infants who developed NEC (OR 2.3, 95% CI 1.1,4.8, P = 0.003) than for children in the control group. Infants who developed NEC were more likely to have a history of intrauterine exposure to ampicillin in the immediate prenatal period than infants who did not develop NEC.

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The authors declare that there are no conflicts of interest present.