detinfДЕТСКИЕ ИНФЕКЦИИCHILDREN INFECTIONS2072-81072618-8139Association of Pediatricians and Infection Disease doctors10.22627/2072-8107-2021-20-3-39-47detinf-619Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEW OF THE LITERATUREC. difficile-инфекция у новорожденных: решенные и нерешенные вопросыC. difficile-infection and microbyota in newborns: resolved and outstanding issueshttps://orcid.org/0000-0002-0895-6707МазанковаЛ. Н.MazankovaL. N.

Мазанкова Людмила Николаевна – доктор медицинских наук, профессор, заведующая кафедры детских инфекционных болезней РМАНПО, главный внештатный специалист по инфекционным болезням у детей.

Москва.

MD, Professor.

Moscow.

mazankova@list.ruhttps://orcid.org/0000-0001-7014-5393ПерловскаяС. Г.PerlovskayaS. G.

Перловская Светлана Геннадьевна - врач-педиатр.

Москва.

Moscow.

grow-up@mail.ruhttps://orcid.org/0000-0001-9758-0053РыбальченкоО. В.RubalchenkoO. V.

Рыбальченко Оксана Владимировна – доктор биологических наук, профессор кафедры физиологии.

Санкт-Петербург.

MD, Professor.

Sankt-Peterburg.

ovr@inbox.ruРоссийская медицинская академия непрерывного профессионального образования МЗ РФРоссияRussian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian FederationRussian FederationДГКБ № 9 им. Г.Н. Сперанского ДЗМРоссияChildren's City Hospital No 9Russian FederationСанкт-Петербургский государственный университет, кафедра физиологии, медицинский факультетРоссияEducational and Research Medical Center in the Administrative Department of the President of the Russian FederationRussian Federation2021061020212033947Copyright © Мазанкова Л.Н., Перловская С.Г., Рыбальченко О.В., 20212021Мазанкова Л.Н., Перловская С.Г., Рыбальченко О.В.Mazankova L.N., Perlovskaya S.G., Rubalchenko O.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://detinf.elpub.ru/jour/article/view/619

В статье представлен аналитический обзор работ отечественных и зарубежных авторов по проблеме изучения особенностей формирования микробиоты кишечника и факторов риска развития микродисбиоза у новорожденных с активацией условно патогенных бактерий (УПБ), в том числе Clostridioides difficile. Особое внимание уделено влиянию антибиотиков на состояние микробиоты кишечника и активацию токсигенных штаммов C. difficile. Приведены разнонаправленные взгляды на роль токсигенных штаммов C. difficile в развитии инфекционной патологии новорожденных.

The article presents an analytical review of the works of domestic and foreign authors on the problem of studying the peculiarities of the formation of the intestinal microbiota and risk factors for the development of microdysbiosis in newborns with the activation of opportunistic bacteria, including C. difficile. Special attention is paid to the effect of antibiotics on the state of the intestinal microbiota and the activation of toxigenic strains of C. difficile. Divergent views on the role of toxigenic strains of C. difficile in the development of infectious pathology of newborns are presented.

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The authors declare that there are no conflicts of interest present.