<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">detinf</journal-id><journal-title-group><journal-title xml:lang="ru">ДЕТСКИЕ ИНФЕКЦИИ</journal-title><trans-title-group xml:lang="en"><trans-title>CHILDREN INFECTIONS</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-8107</issn><issn pub-type="epub">2618-8139</issn><publisher><publisher-name>Association of Pediatricians and Infection Disease doctors</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22627/2072-8107-2021-20-4-18-21</article-id><article-id custom-type="elpub" pub-id-type="custom">detinf-636</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Клинико-лабораторная характеристика новой коронавирусной инфекции у детей в Ставропольском крае</article-title><trans-title-group xml:lang="en"><trans-title>Clinical, laboratory characteristics of a new Сoronavirus Infection in children in the Stavropol Territory</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6349-8796</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Безроднова</surname><given-names>С. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Bezrodnova</surname><given-names>S. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Безроднова Светлана Михайловна, д.м.н., профессор, заведующая кафедрой педиатрии</p><p>Ставрополь</p></bio><bio xml:lang="en"><p>Stavropol</p></bio><email xlink:type="simple">bezrodnova.s@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4353-4777</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Яценко</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Yatsenko</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Яценко Наталья Александровна, к.м.н., главный врач</p><p>Ставрополь</p></bio><bio xml:lang="en"><p>Stavropol</p></bio><email xlink:type="simple">natali.yanet@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7762-7790</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сиражов</surname><given-names>Г. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Sirazhov</surname><given-names>G. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сиражов Гаджи Махмудапандиевич, ординатор кафедры педиатрии</p><p>Ставрополь</p></bio><bio xml:lang="en"><p>Stavropol</p></bio><email xlink:type="simple">dr.sir@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБОУ ВО Ставропольский государственный медицинский университет Министерства здравоохранения России<country>Россия</country></aff><aff xml:lang="en">Stavropol State Medical University of the Ministry of Healthcare of the Russian Federation<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ГБУЗ Ставропольского края Краевая специализированная клиническая инфекционная больница<country>Россия</country></aff><aff xml:lang="en">Regional Clinical Hospital of Infectious Diseases<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>10</day><month>12</month><year>2021</year></pub-date><volume>20</volume><issue>4</issue><fpage>18</fpage><lpage>21</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Безроднова С.М., Яценко Н.А., Сиражов Г.М., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Безроднова С.М., Яценко Н.А., Сиражов Г.М.</copyright-holder><copyright-holder xml:lang="en">Bezrodnova S.M., Yatsenko N.A., Sirazhov G.M.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://detinf.elpub.ru/jour/article/view/636">https://detinf.elpub.ru/jour/article/view/636</self-uri><abstract><p>Новая коронавирусная инфекция у детей чаще протекает бессимптомно или в легких формах, однако, в последнее время все чаще регистрируются тяжелые случаи болезни, в мире зарегистрированы единичные летальные исходы у детей.</p><p>Целью исследования явился клинико-лабораторный анализ особенностей течения новой коронавирусной инфекции у детей в Ставропольском крае.</p><p>На основе ретроспективного исследования проанализировано 86 медицинских карт стационарных больных детей, находившихся на лечении в государственном бюджетном учреждении здравоохранения Ставрополького края «Краевая специализированная клиническая инфекционная больница» с диагнозом U07.1 Новая коронавирусная инфекция за период с апреля 2020 по апрель 2021 г.</p><p>Большинство госпитализированных больных переносило COVID-19 в среднетяжелой форме — 59,3%. Дети чаще инфицировались в семейных очагах — 51,2%. В 60% случаев дети госпитализировались на 4—7 сутки от начала заболевания. В клинической картине ведущими симптомами являлись: лихорадка (76,7%), кашель (55,8%), слабость (38,4%), ринит (20,9%), гастроинтестинальные симптомы (12,8%). Пневмония была выявлена у 37,2% детей. Все больные были выписаны с клиническим выздоровлением.</p></abstract><trans-abstract xml:lang="en"><p>A new coronavirus infection in children is more often asymptomatic or in mild forms, however, more and more severe cases of the disease have been recorded recently, and single deaths in children have been recorded in the world.</p><p>The aim of the study was a clinical and laboratory analysis of the features of the course of a new coronavirus infection in children in the Stavropol Territory.</p><p>Based on a retrospective study, 86 medical records of inpatient children who were treated at the Regional Specialized Clinical Infectious Diseases Hospital of the Stavropol Territory were analyzed with a diagnosis of U07.1 New coronavirus infection for the period from April 2020 to April 2021.</p><p>The majority of hospitalized patients suffered from COVID-19 in a moderate form 59.3%. Children are more likely to become infected in family foci of infection – 51.2%. In 60% of cases, children are hospitalized 4—7 days from the onset of the disease. In the clinical picture, the leading symptoms were: fever (76.7%), cough (55.8%), weakness (38.4%), rhinitis (20.9%), gastrointestinal symptoms (12.8%). Pneumonia was detected in 37.2% of children. All patients were discharged with clinical recovery.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>новая коронавирусная инфекция</kwd><kwd>COVID-19</kwd><kwd>SARS-CoV-2</kwd><kwd>пневмония</kwd><kwd>дети</kwd></kwd-group><kwd-group xml:lang="en"><kwd>new coronavirus infection</kwd><kwd>COVID-19</kwd><kwd>SARS-CoV-2</kwd><kwd>pneumonia</kwd><kwd>children</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Zhonghua Liu Xing Bing Xue Za Zhi. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China. 2020; 41(2):145—151. DOI: 10.3760/cma.j.issn.0254-6450.2020.02.003</mixed-citation><mixed-citation xml:lang="en">Zhonghua Liu Xing Bing Xue Za Zhi. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China. 2020; 41(2):145—151. DOI: 10.3760/cma.j.issn.0254-6450.2020.02.003</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">World Health Organization. Coronavirus disease 2019 (COVID-19) situation report-51. 2020; Geneva, Switzerland: World Health Organization, https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200311-sitrep-51-covid-19.pdf?sfvrsn=1ba62e57_10</mixed-citation><mixed-citation xml:lang="en">World Health Organization. Coronavirus disease 2019 (COVID-19) situation report-51. 2020; Geneva, Switzerland: World Health Organization, https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200311-sitrep-51-covid-19.pdf?sfvrsn=1ba62e57_10</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Liu W., Zhang Q., Chen J. et al. Detection of COVID-19 in Children in Early January 2020 in Wuhan, China. N. Engl. J. Med. 2020; 382(14):1370—1371. DOI: 10.1056/NEJMc2003717.</mixed-citation><mixed-citation xml:lang="en">Liu W., Zhang Q., Chen J. et al. Detection of COVID-19 in Children in Early January 2020 in Wuhan, China. N. Engl. J. Med. 2020; 382(14):1370—1371. DOI: 10.1056/NEJMc2003717.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Александрович Ю.С., Алексеева Е.И., Баркадзе М.Д., и др. Особенности клинических проявлений и лечения заболевания, вызванного новой коронавирусной инфекцией (COVID-19) у детей. Версия 2. Педиатрическая фармакология. 2020; 17(3): 187—212.</mixed-citation><mixed-citation xml:lang="en">Aleksandrovich Iu.S., Alekseeva E.I., Barkadze M.D., et al. Osobennosti klinicheskikh proiavlenii i lecheniia zabolevaniia, vyzvannogo novoi koronavirusnoi infektsiei (COVID-19) u detei. Version 2. Pediatric Pharmacology. 2020; 17(3):187—212. (in Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Loske J., Röhmel J., Lukassen S. et al. Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children. Nat Biotechnol. 2021. DOI: 10.1038/s41587-021-01037-9</mixed-citation><mixed-citation xml:lang="en">Loske J., Röhmel J., Lukassen S. et al. Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children. Nat Biotechnol. 2021. DOI: 10.1038/s41587-021-01037-9</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Lee P.I., Hu Y.L., Chen P.Y., Huang Y.C. Hsueh P.R. Are children less susceptible to COVID-19? J. Microbiol Immunol Infect. 2020; 53(3):371—372.</mixed-citation><mixed-citation xml:lang="en">Lee P.I., Hu Y.L., Chen P.Y., Huang Y.C. Hsueh P.R. Are children less susceptible to COVID-19? J. Microbiol Immunol Infect. 2020; 53(3):371—372.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Методические рекомендации. Особенности клинических проявлений и лечения заболевания, вызванного новой коронавирусной инфекцией (COVID 19) у детей. Версия 2 (03.07.2020). М., 2020:74. https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/050/914/original/03062020_дети_COVID-19_v2.pdf</mixed-citation><mixed-citation xml:lang="en">https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/050/914/original/03062020_дети_COVID-19_v2.pdf Guidelines. Features of the clinical manifestations and treatment of the disease caused by the new coronavirus infection (COVID 19) in children. Version 2 (07/03/2020). M., 2020:74. (in Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Заплатников А.Л., Свинцицкая В.И. COVID-19 и дети. РМЖ. 2020; 6:20—22.</mixed-citation><mixed-citation xml:lang="en">Zaplatnikov A.L., Svinciczkaya V.I. COVID-19 and children. RMZh. 2020; 6:20—22. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Tu-Hsuan Chang, Jhong-Lin Wu, Luan-Yin Chang. Clinical characteristics and diagnostic challenges of pediatric COVID-19: A systematic review and meta-analysis. J. Formos Med Assoc. 2020; 119(5):982—989. DOI: 10.1016/j.jfma.2020.04.007</mixed-citation><mixed-citation xml:lang="en">Tu-Hsuan Chang, Jhong-Lin Wu, Luan-Yin Chang. Clinical characteristics and diagnostic challenges of pediatric COVID-19: A systematic review and meta-analysis. J. Formos Med Assoc. 2020; 119(5):982—989. DOI: 10.1016/j.jfma.2020.04.007</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">She J., Liu L., Liu W. COVID-19 epidemic: Disease characteristics in children. J. Med. Virol. 2020; 92(7):747—754. DOI: 10.1002/jmv.25807</mixed-citation><mixed-citation xml:lang="en">She J., Liu L., Liu W. COVID-19 epidemic: Disease characteristics in children. J. Med. Virol. 2020; 92(7):747—754. DOI: 10.1002/jmv.25807</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
