<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">detinf</journal-id><journal-title-group><journal-title xml:lang="ru">ДЕТСКИЕ ИНФЕКЦИИ</journal-title><trans-title-group xml:lang="en"><trans-title>CHILDREN INFECTIONS</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-8107</issn><issn pub-type="epub">2618-8139</issn><publisher><publisher-name>Association of Pediatricians and Infection Disease doctors</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22627/2072-8107-2022-21-3-52-55</article-id><article-id custom-type="elpub" pub-id-type="custom">detinf-754</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СЛУЧАЙ ИЗ ПРАКТИКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CASE FROM PRACTICAL</subject></subj-group></article-categories><title-group><article-title>Клинический случай новой коронавирусной инфекции с поражением сердца у ребенка</article-title><trans-title-group xml:lang="en"><trans-title>A clinical case of the new coronavirus infection with cardiac involvement in a child</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4800-5092</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гашина</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gashina</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гашина Елена Александровна, к.м.н., доцент кафедры детских инфекционных болезней</p><p> </p></bio><bio xml:lang="en"><p>Gashina E., PhD</p></bio><email xlink:type="simple">l.gashina@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4315-5120</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лобова</surname><given-names>Е. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Lobova</surname><given-names>E. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лобова Елена Федоровна, к.м.н., доцент кафедры детских инфекционных болезней</p><p> </p></bio><bio xml:lang="en"><p>Lobova E., PhD</p></bio><email xlink:type="simple">lobova-lf@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5759-6288</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шефер</surname><given-names>Е. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Shefer</surname><given-names>E. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шефер Екатерина Петровна, заместитель главного врача по медицинской части</p></bio><email xlink:type="simple">ecaterina.shefer.1973@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Омский государственный медицинский университет Минздрава России<country>Россия</country></aff><aff xml:lang="en">Omsk State Medical University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ГДКБ №3 г. Омска, инфекционный стационар<country>Россия</country></aff><aff xml:lang="en">Omsk Oblast City Children's Clinical Hospital №3, Infectious Diseases Hospital<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>02</day><month>10</month><year>2022</year></pub-date><volume>21</volume><issue>3</issue><fpage>52</fpage><lpage>55</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гашина Е.А., Лобова Е.Ф., Шефер Е.П., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Гашина Е.А., Лобова Е.Ф., Шефер Е.П.</copyright-holder><copyright-holder xml:lang="en">Gashina E.A., Lobova E.F., Shefer E.P.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://detinf.elpub.ru/jour/article/view/754">https://detinf.elpub.ru/jour/article/view/754</self-uri><abstract><p>Продолжающаяся пандемия новой коронавирусной инфекции позволяет открывать новые сведения о клиническом течении заболевания. Несмотря на более редкую регистрацию и легкое течение COVID-19 у детей, появляются данные о более тяжелых проявлениях, в том числе, поражения сердечно-сосудистой системы. Воздействие SARS-CoV-2 может приводить к развитию миокардитов, нарушению ритма, сердечной недостаточности и др.</p><p>По данным инфекционного стационара г. Омска, изменения со стороны сердца регистрировались у 5,8% госпитализированных детей с COVID-19. В статье представлен клинический случай новой коронавирусной инфекции у ребенка 15 лет, находившегося на лечении в инфекционном стационаре БУЗОО ГДКБ №3 г. Омска. Диагноз был подтвержден путем исследования мазков из носоглотки на наличие РНК SARS-CoV-2 методом ПЦР. Особенностью течения инфекции у данного пациента явилось развитие миокардита на фоне заболевания средней степени тяжести без наличия коморбидной патологии.</p></abstract><trans-abstract xml:lang="en"><p>The ongoing pandemic of the new coronavirus infection allows us to discover new information concerning the clinical course of the disease. Despite the rarer registration and mild course of COVID-19 in children, we get new data on more severe manifestations in the form of damage to various organs including cardiovascular system. SARS-CoV-2 can lead to myocarditis development, arrhythmia, heart failure, etc.</p><p>According to an infectious diseases hospital in Omsk, heart changes were recorded in 5.8% of hospitalized children with COVID-19. The article presents a clinical case of the new coronavirus infection in a child of 15 years old who was on treatment in the infection diseases hospital of Budgetary Healthcare Institution of Omsk Oblast City Children's Clinical Hospital №3 of Omsk. The diagnosis was confirmed by examining nasopharyngeal smears for evidence of RNA SARS-CoV-2 by PCR. The course of infection in this patient is characterized by myocarditis development following medium severity disease without comorbid pathology.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>новая коронавирусная инфекция</kwd><kwd>миокардит</kwd><kwd>COVID-19</kwd></kwd-group><kwd-group xml:lang="en"><kwd>children</kwd><kwd>new coronavirus infection</kwd><kwd>myocarditis</kwd><kwd>COVID-19</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Shen K, Yang Y. Diagnosis and treatment of 2019 novel coronavirus infection in children: a pressing issue. World J Pediatr. 2020; 16(3):219—221. doi: 10.1007/s12519-020-00344-6.</mixed-citation><mixed-citation xml:lang="en">Shen K, Yang Y. Diagnosis and treatment of 2019 novel coronavirus infection in children: a pressing issue. World J Pediatr. 2020; 16(3):219—221. doi: 10.1007/s12519-020-00344-6.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Таgarro A, Epalza С, Santos М, et al. Screening and severity of Coronavirus disease 2019 (COVID-19) in children in Madrid, Spain. JAMA Pediatr. 2020; e201346. doi: 10.1001/jamapediatrics. 2020.1346.</mixed-citation><mixed-citation xml:lang="en">Таgarro A, Epalza С, Santos М, et al. Screening and severity of Coronavirus disease 2019 (COVID-19) in children in Madrid, Spain. JAMA Pediatr. 2020; e201346. doi: 10.1001/jamapediatrics. 2020.1346.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Горелов А.В., Николаева С.В., Акимкин В.Г. Новая коронавирусная инфекция COVID-19: особенности течения у детей в Российской Федерации. Педиатрия. 2020; 99(6):57—62.</mixed-citation><mixed-citation xml:lang="en">Gorelov A.V., Nikolaeva S.V., Akimkin V.G. New coronavirus infection COVID-19: features of the course in childrenin the Russian Federation. Pediatriya. 2020; 99(6):57—62. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Белан Ю.Б., Гашина Е.А., Лобова Е.Ф., Безрукова Л.А. Коронавирусная инфекция у детей в Омской области. Детские инфекции. 2020; 19(4):30—33.</mixed-citation><mixed-citation xml:lang="en">Belan Yu.B., Gashina E.A., Lobova E.F., Bezrukova L.A. Coronoviris infection in children in Omsk region. Detskie Infektsii=Children's Infections. 2020; 19(4):30—33. doi.org/10.22627/2072-8107-2020-19-4-30-33 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Hu J, R. Florido, E. Lipson et al. Cardiovascular toxicities associated with immune checkpoint inhibitors. J. Cardiovasc. Res. 2019 Apr 15; 115(5):868. doi: 10.1093/cvr/cvz082.</mixed-citation><mixed-citation xml:lang="en">Hu J, R. Florido, E. Lipson et al. Cardiovascular toxicities associated with immune checkpoint inhibitors. J. Cardiovasc. Res. 2019 Apr 15; 115(5):868. doi: 10.1093/cvr/cvz082.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Бабаченко И.В., Левина А.С., Чупрова С.Н., Шарипова Е.В. Поражения сердца при респираторных инфекциях у детей. Журнал инфектологии. 2016; 8(4):20—25.</mixed-citation><mixed-citation xml:lang="en">Babachenko I.V., Levina A.S., Chuprova S.N., Sharipova E.V. Cardiac involvement during respiratory infections in children. Zhurnal Infektologii. 2016; 8(4):20—25. https://doi.org/10.22625/2072-6732-2016-8-4-20-25 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Дерюгин М.В., С.А. Бойцов. Хронические миокардиты. СПб.: ЭЛБИ-СПб, 2005:288.</mixed-citation><mixed-citation xml:lang="en">Deryugin M.V., S.A. Boytsov. Chronic myocarditis. Saint-Petersburg: ELBI-SPb, 2005:288.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Nishiga M, Wang D.W, Han Y, et al. COVID-19 and cardiovascular disease. Nat Rev Cardiol. 2020; 17:543. https: // doi.org/1038/s 41569-020-0413-9</mixed-citation><mixed-citation xml:lang="en">Nishiga M, Wang D.W, Han Y, et al. COVID-19 and cardiovascular disease. Nat Rev Cardiol. 2020; 17:543. https: // doi.org/1038/s 41569-020-0413-9</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang H, Penninger JM, Li Y., et al. Angioten-sin-converting enzyme 2 (ACE2) as a SARS-CoV-2 re-ceptor: molecular mechanisms and potential therapeu-tic target. Intensive Care Med. 2020 Apr; 46(4):586—590. doi:10.1007/s00134-020-05985-9.</mixed-citation><mixed-citation xml:lang="en">Zhang H, Penninger JM, Li Y., et al. Angioten-sin-converting enzyme 2 (ACE2) as a SARS-CoV-2 re-ceptor: molecular mechanisms and potential therapeu-tic target. Intensive Care Med. 2020 Apr; 46(4):586—590. doi:10.1007/s00134-020-05985-9.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Коган Е.А., Куклева А.Д., Березовский Ю.С., Благова О.В., Жарков Н.В., Айнетдинова Д.Х., Демяшкин Г.А. Клинико-морфологическая характеристика SARS-CoV-2-ассоциированного миокардита, подтвержденного наличием РНК и белков вируса в ткани миокарда. Архив патологии. 2021; 83(4):5—13.</mixed-citation><mixed-citation xml:lang="en">Kogan E.A., Kukleva A.D., Berezovskij Yu.S., Blagova O.V., Zharkov N.V., Ajnetdinova D.H., Demyashkin G.A. Clinical and morphological characteristics SARS-CoV-2-associated myocarditis confirmed by the existence of RNA and viral proteins in myocardial tissue. Arhiv Patologii. 2021; 83(4):5—13. https://doi.org/10.17116/patol2021830415 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Shi S, Qin M, Shen B, Cai Y, Liu T, Yang F et al. Association of cardiac injury with mortality in hospitalized patients with COVID- 19 in Wuhan, China. JAMA Cardiol. 2020:e200950. doi:10.1001/ jamacardio.2020.0950</mixed-citation><mixed-citation xml:lang="en">Shi S, Qin M, Shen B, Cai Y, Liu T, Yang F et al. Association of cardiac injury with mortality in hospitalized patients with COVID- 19 in Wuhan, China. JAMA Cardiol. 2020:e200950. doi:10.1001/ jamacardio.2020.0950</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Ferrero P, Piazza I, Bonino C, Ciuffreda M. Patterns of myocardial involvement in children during COVID-19 pandemic: Early experience from northern Italy. Ann Pediatr Card 2020; 13(3):230—233. doi: 10.4103/apc.APC_77_20</mixed-citation><mixed-citation xml:lang="en">Ferrero P, Piazza I, Bonino C, Ciuffreda M. Patterns of myocardial involvement in children during COVID-19 pandemic: Early experience from northern Italy. Ann Pediatr Card 2020; 13(3):230—233. doi: 10.4103/apc.APC_77_20</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Fischer Q, Brillat-Savarin N, Ducrocq G, Ou P Case report of an isolated myocarditis due to COVID-19 infection in a paediatric patient. Eur Heart J Case Rep. 2020 Jul 3; 4(FI1):1—5. doi: 10.1093/ehjcr/ytaa180.</mixed-citation><mixed-citation xml:lang="en">Fischer Q, Brillat-Savarin N, Ducrocq G, Ou P Case report of an isolated myocarditis due to COVID-19 infection in a paediatric patient. Eur Heart J Case Rep. 2020 Jul 3; 4(FI1):1—5. doi: 10.1093/ehjcr/ytaa180.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Александрович Ю.С., Алексеева Е.И., Бакрадзе М.Д. и др. Особенности клинических проявлений и лечения заболевания, вызванного новой коронавирусной инфекцией (COVID-19), у детей. Версия 2. Педиатрическая фармакология. 2020; 17(3).</mixed-citation><mixed-citation xml:lang="en">Aleksandrovich Yu.S., Alekseeva E.I., Bakradze M.D. and al. Clinical features and management of the disease caused by coronavirus infection (COVID-19) in children. Version 2. Pediatricheskaya Farmakologiya. 2020, 17(3). DOI: 10.15690/pf.v17i3.2123 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Grimaud M., Starck J., Levy M. et al. Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children. Ann. Intensive Care. 2020; 10(1):69.</mixed-citation><mixed-citation xml:lang="en">Grimaud M., Starck J., Levy M. et al. Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children. Ann. Intensive Care. 2020; 10(1):69.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Благова О.В., Коган Е.А. Миокардит: диагностика и лечение в период пандемии. Consilium Medicum. 2021; 23(10):742—749. DOI: 10.26442/20751753.2021.10.200668</mixed-citation><mixed-citation xml:lang="en">Blagova O.V., Kogan E.A. Myocarditis: diagnostics and treatment during the pandemic. Consilium Medicum. 2021; 23(10):742—749. DOI: 10.26442/20751753.2021.10.200668 (In Russ.)</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
