detinfДЕТСКИЕ ИНФЕКЦИИCHILDREN INFECTIONS2072-81072618-8139Association of Pediatricians and Infection Disease doctors10.22627/2072-8107-2023-22-1-14-18detinf-807Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESВозможности прогнозирования неблагоприятных исходов кампилобактериоза у детейPossibilities of prediction of сampylobacteriosis adverse outcomes in childrenhttps://orcid.org/0000-0002-1730-8576ЕрмоленкоК. Д.ErmolenkoK. D.

Ермоленко Константин Дмитриевич, к. м. н., научный сотрудник отдела кишечных инфекций

Санкт-Петербург

Ermolenko K.

Saint Petersburg

ermolenko.kd@yandex.ruФГБУ Детский научно-клинический центр инфекционных болезней ФМБА РоссииРоссияPediatric Research and Clinical Center for Infectious DiseasesRussian Federation2023310320232211418Copyright © Ермоленко К.Д., 20232023Ермоленко К.Д.Ermolenko K.D.This work is licensed under a Creative Commons Attribution 4.0 License.https://detinf.elpub.ru/jour/article/view/807

Помимо проблемы высокой заболеваемости кампилобактериозом детского населения, существует высокий риск развития постинфекционных функциональных гастроинтестинальных расстройств (ПФГИР). Цель: установить частоту и структуру функциональных гастроинтестинальных расстройств у реконвалесцентов кампилобактериоза. Материалы и методы. Наблюдалось 200 детей с кампилобактериозом, проходивших лечение в ДНКЦИБ ФМБА России в период 2018—2021 гг.. Проводилось последующее катамнестическое наблюдение в течение 12 месяцев. Результаты. Полный срок наблюдения прошли 180 (90%) пациентов. На момент начала катамнестического только у 26 (13%) детей имелись жалобы на состояния здоровья: боли в животе при приёме пищи (n = 15: 7,5%), метеоризм (n = 19; 9,5%), кашицеобразный стул, снижение аппетита (n = 5; 2,5%), запоры (n = 10; 5,0%). Наиболее часто жалобы со стороны органов пищеварения появлялись в период с 90 по 180 дни. В эти сроки у детей, перенесших кампилобактериоз, наиболее часто отмечались периодические боли, дискомфорт в животе (n = 64, 32%) и запоры (n = 53; 26,5%). В старшей группе диагностированы: синдром раздраженного кишечника (n = 19; 51,4%), функциональная диспепсия (n = 14; 37,8%) и функциональные запоры (n = 4; 10,8%). В младшей возрастной группе диагностированы: функциональные запоры (n = 18; 60,0%) и функциональная диарея (n = 12; 40,0%). Выводы. Таким образом, у 67 (33,5%) детей — реконвалесцентов кампилобактериоза выявлены ПФГИР. На основании разработанной математико-статистической модели прогнозирования ПФГИР к их предикторам можно отнести: поступление в стационар в поздние сроки, тяжесть кампилобактериоза по шкале Кларка, назначение нескольких курсов антибактериальных препаратов, вынужденный перевод на искусственное вскармливание, возраст, наличие гемоколита, выраженность дегидратации.

In addition to the problem of high morbidity in the child population, there is a high risk of developing post-infectious functional gastrointestinal disorders (PFGID). The aim of the study was to establish the frequency and structure of functional gastrointestinal disorders in campylobacteriosis convalescents. Patients and methods. The study included 200 children who were treated in a specialized department of the DNNCIB FMBA of Russia in the period 2018—2021. associated with campylobacteriosis. Clinical observation of patients was carried out in a hospital, followed by follow-up observation for 12 months. Results. 180 (90%) patients passed the full observation period. At the time of the start of the follow-up observation only 26 (13%) children had complaints about health conditions: abdominal pain when eating (n = 15; 7.5%), flatulence (n = 19; 9 .5%), mushy stools, loss of appetite (n = 5; 2.5%), constipation (n = 10; 5.0%). Most often, the appearance of complaints from the digestive organs appeared in the period from 90 to 180 days. Among the symptoms detected in children after campylobacteriosis, the most common were the appearance of periodic pain, abdominal discomfort (n = 64, 32%) and constipation (n = 53; 26.5%). The older group was diagnosed with: irritable bowel syndrome (n = 19; 51.4%), functional dyspepsia (n = 14; 37.8%) and functional constipation (n = 4; 10.8%). In the younger age group, the following were diagnosed: functional constipation (n = 18; 60.0%) and functional diarrhea (n = 12; 40.0%). Conclusions. The dynamic dispensary observation of campylobacteriosis convalescents made it possible to diagnose PFGIR in 67 (33.5%) children. On the basis of the study, a mathematical and statistical model for predicting PFGIR was developed, which allows, based on the assessment of clinical and anamnestic signs, to identify children at risk. The predictors of PFGIR in children who have had campylobacteriosis included in the prognosis model include: admission to the hospital at a late stage of the disease with severe severity of campylobacteriosis on the Clark scale, the appointment of several courses of antibacterial drugs, forced transfer to artificial feeding, age, the presence of hemocolitis, the severity of dehydration.

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The authors declare that there are no conflicts of interest present.