detinfДЕТСКИЕ ИНФЕКЦИИCHILDREN INFECTIONS2072-81072618-8139Association of Pediatricians and Infection Disease doctors10.22627/2072-8107-2024-23-2-31-38detinf-946Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEW OF THE LITERATUREВрожденная цитомегаловирусная инфекция: новые ответы на старые проблемыCongenital cytomegalovirus infection: new answers to old problemshttps://orcid.org/0000-0002-2864-1446ХижакЯ. Р.KhizhakYa. R.

Хижак Яна Романовна, ординатор кафедры госпитальной педиатрии им. академика В.А.Таболина

Москва

Moscow

hijak.iana@mail.ruhttps://orcid.org/0000-0001-7305-9036СаркисянЕ. А.SarkisyanH. A.

Саркисян Егине Альбертовна, к.м.н, доцент кафедры госпитальной педиатрии им. академика В.А.Таболина

Москва

Moscow

heghinesarg@gmail.comhttps://orcid.org/0000-0002-9808-1931КомароваА. А.KomarovaA. A.

Комарова Анна Анатольевна, ординатор кафедры инфекционных болезней у детей педиатрического факультета

Москва

Moscow

komarova.anna.09@gmail.comhttps://orcid.org/0009-0001-0817-4959МироноваВ. А.MironovaV. A.

Миронова Вероника Андреевна, студентка 4 курса педиатрического факультета

Москва

Moscow

mironovaveronika9048@gmail.comhttps://orcid.org/0000-0002-3091-6170ЖуравлеваИ. В.ZhuravlevaI. V.

Журавлева Ирина Витальевна, клинический ординатор кафедры госпитальной педиатрии им. академика В.А. Таболина педиатрического факультета

Москва

Moscow

ira.sindyankina@mail.ruhttps://orcid.org/0000-0003-3690-7782СаркисянМ. А.SarkisyanM. A.

Саркисян Микаел Альбертович, д.м.н., заведующий отделом клинической медицины Научно-исследовательского медико-стоматологического института

Москва

Moscow

sarmika100mat@gmail.comhttps://orcid.org/0000-0002-9567-6761ШумиловП. В.ShumilovP. V.

Шумилов Петр Валентинович, д.м.н., профессор, заведующий кафедрой госпитальной педиатрии им. академика В.А. Таболина

Москва

Moscow

peter_shumilov@mail.ruФГАОУ ВО "Российский национальный исследовательский медицинский университет имени Н.И. Пирогова" Министерства здравоохранения Российской ФедерацииPirogov Russian National Research Medical University of the Ministry of Health of the Russian FederationФГАОУ ВО "Российский национальный исследовательский медицинский университет имени Н.И. Пирогова" Министерства здравоохранения Российской Федерации; Детская городская клиническая больница № 9 им. Г.Н. Сперанского Департамента здравоохранения города МосквыPirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation; Children’s City Clinical Hospital No. 9 named after G.N. SperanskyМосковский государственный медико-стоматологический университет имени А.И. ЕвдокимоваYevdokimov Moscow State University of Medicine and Dentistry2024240620242323138Copyright © Хижак Я.Р., Саркисян Е.А., Комарова А.А., Миронова В.А., Журавлева И.В., Саркисян М.А., Шумилов П.В., 20242024Хижак Я.Р., Саркисян Е.А., Комарова А.А., Миронова В.А., Журавлева И.В., Саркисян М.А., Шумилов П.В.Khizhak Y.R., Sarkisyan H.A., Komarova A.A., Mironova V.A., Zhuravleva I.V., Sarkisyan M.A., Shumilov P.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://detinf.elpub.ru/jour/article/view/946

Врожденная цитомегаловирусная инфекция - одна из самых частых TORCH-инфекций, характеризующаяся широким спектром клинических проявлений, преимущественно с полиорганным характером поражения и нередко инвалидизирующим течением. Результатом антенатального инфицирования цитомегаловирусом является высокая частота врожденных пороков развития, часто сопровождающихся такими нарушениями, как потеря слуха, зрения, двигательный и когнитивный дефицит. Несмотря на наличие современных отечественных клинических рекомендаций, изучение данной патологии остается актуальным по настоящее время. За последнее время был достигнут значительный прогресс в изучении данного заболевания. Ежегодно проводятся новые исследования по актуальным вопросам диагностики, лечения и реабилитации при врожденной цитомегаловирусной инфекции. В данной статье представлен обзор современной литературы, охватывающий последние данные о молекулярных основах патогенеза, особенностях клинических проявлений, актуальных подходов к диагностике и терапии врожденной цитомегаловирусной инфекции.

Congenital cytomegalovirus infection is one of the most common TORCH infections, characterized by a wide range of clinical manifestations, predominantly with multiple organ lesions and often a disabling course. The result of antenatal infection with cytomegalovirus is a high incidence of congenital malformations, often accompanied by disorders such as hearing loss, vision loss, motor and cognitive deficits. Despite the presence of modern domestic clinical recommendations, the study of this pathology remains relevant to the present day. Recently, significant progress has been made in the study of this disease. Every year, new research is conducted on topical issues of diagnosis, treatment and rehabilitation for congenital cytomegalovirus infection. This article provides a review of modern literature, covering the latest data on the molecular basis of pathogenesis, features of clinical manifestations, current approaches to the diagnosis and treatment of congenital cytomegalovirus infection.

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The authors declare that there are no conflicts of interest present.