detinfДЕТСКИЕ ИНФЕКЦИИCHILDREN INFECTIONS2072-81072618-8139Association of Pediatricians and Infection Disease doctors10.22627/2072-8107-2024-23-4-46-53detinf-995Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEW OF THE LITERATUREЭпидемиологическая и клиническая значимость ротавирусной инфекции в период вакцинацииEpidemiological and clinical significance of rotavirus infection during the vaccination periodhttps://orcid.org/0000-0002-2714-0535БуханцоваЕ. С.BukhantsovaE. S.

Буханцова Елена Сергеевна, аспирант кафедры инфекционных болезней у детей 

Москва 

Moscow 

dr.buxancova@mail.ruhttps://orcid.org/0000-0003-0273-6700КовалевО. Б.KovalevO. В.

Ковалев Олег Борисович, д.м.н., профессор кафедры инфекционных болезней у детей 

Москва 

Moscow 

doctor87@list.ruhttps://orcid.org/0000-0002-6033-6695ШамшеваО. В.ShamshevaO. V.

Шамшева Ольга Васильевна, д.м.н., профессор, зав. кафедрой инфекционных болезней у детей 

Москва 

Moscow 

ch-infection@mail.ruhttps://orcid.org/0000-0003-2840-7382МолочковаО. В.MolochkovaO. V.

Молочкова Оксана Вадимовна, к.м.н., доцент кафедры инфекционных болезней у детей 

Москва 

Moscow 

ci-journal@mail.ruhttps://orcid.org/0009-0006-2319-0080КаменскаяИ. Б.KamenskayaI. B.

Каменская Ирина Борисовна, ординатор кафедры инфекционных болезней у детей 

Москва 

Moscow 

irchi98@mail.ruРоссийский национальный исследовательский медицинский университет имени Н.И. Пирогова Министерства здравоохранения Российской Федерации (Пироговский университет)РоссияPirogov Russian National Research Medical University, Ministry of Health of the Russian FederationRussian Federation2024161120242344653Copyright © Буханцова Е.С., Ковалев О.Б., Шамшева О.В., Молочкова О.В., Каменская И.Б., 20242024Буханцова Е.С., Ковалев О.Б., Шамшева О.В., Молочкова О.В., Каменская И.Б.Bukhantsova E.S., Kovalev O.В., Shamsheva O.V., Molochkova O.V., Kamenskaya I.B.This work is licensed under a Creative Commons Attribution 4.0 License.https://detinf.elpub.ru/jour/article/view/995

Ротавирусная инфекция является одной из ведущих причин тяжелой диареи у детей младше пяти лет во всем мире и вносит значительный вклад в детскую смертность. Внедрение вакцинации против ротавирусной инфекции в Российский календарь по эпидемическим показаниям не влияет на эпидемиологическую ситуацию в связи с низким охватом вакцинацией. В настоящей статье представлен обзор исследований, оценивающих клиническую значимость ротавирусной инфекции в условиях массовой вакцинации, а также ее влияние на циркуляцию ротавирусных генотипов. Нами проанализированы данные о распространенности ротавируса, тяжести клинических случаев и изменениях в генетическом разнообразии вируса. Отмечено, что вакцинация снижает тяжесть гастроэнтерита. Несмотря на положительное влияние вакцинации, с течением времени наблюдаются изменения в циркулирующих штаммах вируса, в некоторых странах наблюдается увеличение распространенности других патогенов, таких как норовирус и кампилобактер. Эти данные подчеркивают необходимость продолжения вакцинации и мониторинга за изменениями в структуре возбудителей острых кишечных инфекций для улучшения профилактических мер и контроля за эпидемической ситуацией.

Rotavirus infection is one of the leading causes of severe diarrhea in children under five years of age worldwide and contributes significantly to child mortality. The introduction of rotavirus vaccination for epidemic indications into the Russian National Immunization Schedule has not impacted the epidemiological situation due to low vaccination coverage. This article provides a review of studies evaluating the clinical significance of rotavirus infection in the context of mass vaccination, as well as its impact on the circulation of rotavirus genotypes. We have analyzed data on the prevalence of rotavirus, the severity of clinical cases, and changes in the genetic diversity of the virus. It has been noted that vaccination reduces the severity of gastroenteritis; however, over time, changes in circulating viral strains have been observed. Despite the positive effects of vaccination, some countries have reported an increase in the prevalence of other pathogens, such as norovirus and Campylobacter. These findings emphasize the need to continue vaccination efforts and monitor changes in the structure of pathogens responsible for acute intestinal infections to improve preventive measures and control the epidemiological situation.

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The authors declare that there are no conflicts of interest present.