Mechanisms of HPV transmission among girls of different ages
https://doi.org/10.22627/2072-8107-2025-24-1-37-42
Abstract
Human papillomavirus infection is an infectious disease caused by the human papillomavirus (HPV). Some types of HPV, especially high oncogenic risk types, can lead to cervical cancer, vaginal and vulvar cancer, anal cancer, and oropharyngeal cancer. HPV of low oncogenic risk, in turn, can cause anogenital warts or juvenile recurrent respiratory papillomatosis in childhood. Human papillomavirus infection is the most common sexually transmitted infection in the world. However, there are other important ways of transmission: vertical (from mother to child), horizontal, including infection through inoculated objects and surfaces (fomites), heteroinoculation and autoinoculation (self-infection is the way of virus transmission from one part of the body to another).
In this literature review we analysed data from basic research and clinical studies that show that HPV can survive far beyond its host and potentially can be transmitted not only in sexual contact.
About the Authors
I. V. Karachentsova
Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Moscow
E. V. Sibirskaya
Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation; Russian University of Medicine, Ministry of Health of the Russian Federation; Russian Children's Clinical Hospital of the Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation; Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Moscow
V. M. Denisovets
Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Moscow
M. Y. Chernysheva
Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Moscow
A. F. Nurmatova
Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Moscow
References
1. Derkay CS, Bluher AE: Update on recurrent respiratory papillomatosis. Otolaryngol Clin North Am. 2019; 52(4):669—679. doi: 10.1016/j.otc.2019.03.011
2. Steben M., Duarte-Franco E. Human papillomavirus infection: Epidemiology and pathophysiology. Gynecol Oncol. 2007; 107:S2—S5. doi: 10.1016/j.ygyno.2007.07.067.
3. Serrano B., Brotons M., Bosch F.X., Bruni L. Epidemiology and burden of HPV-related disease. Best Pract. Res. Clin. Obstet. Gynaecol. 2018; 47: 14—26. doi: 10.1016/j.bpobgyn.2017.08.006.
4. Kinzikeeva E.R., Bolis D., Liverani C.A. Human papillomavirus infection. Natural history, epidemiology, risk factors. Medicinskii Vestnik Bashkortostana. 2009. (In Russ.)
5. Forman D., de Martel C., Lacey C.J., Soerjomataram I., Lortet-Tieulent J., Bruni L., Vignat J., Ferlay J., Bray F., Plummer M., et al. Global burden of human papillomavirus and related diseases. Vaccine. 2012; 30(Suppl. 5): F12—F23. doi: 10.1016/j.vaccine.2012.07.055.
6. De Martel C., Plummer M., Vignat J., Franceschi S. Worldwide burden of cancer attributable to HPV by site, country and HPV type. Int. J. Cancer. 2017; 141:664—670. doi: 10.1002/ijc.30716.
7. Stukan' A.I., Chukhray O.Yu., Porkhanov V.A., Murashko R.A., Bodnya V.N., Makarova Yu.M. Human papillomavirus-associated oropharyngeal carcinoma: trends in epidemiology and methods for detecting the virus in tumors. Head and Neck Tumors (HNT). 2018; 8(3):77—83. (In Russ.) https://doi.org/10.17650/2222-1468-2018-8-3-77-83.
8. La Rosa G. Papillomavirus. In: Global Water Pathogen Project. Rose JB and Jimйnez-Cisneros B (eds) (Meschke J.S. and Girones R. (eds) Part 3 Viruses). Michigan State University, E. Lansing, MI, Unesco, 2016.
9. Karachentsova I.V., Sibirskaya E.V., Fomina M.M., Dyadik T.G. The state of the reproductive system of adolescent girls after vaccination against human papillomavirus using a quadrivalent vaccine. Pediatric Рharmacology. 2024; 21(2):111—118. (In Russ.) doi.org/10.15690/pf.v21i2.2716.
10. Fabbrocini G., S. Cacciapuoti and G. Monfrecola. Human Papillomavirus Infection in Child. The Open Dermatology Journal. 2009; 3:111—16.
11. Kombe Kombe AJ, Li B, Zahid A, Mengist HM, Bounda G-A, Zhou Y and Jin T. Epidemiology and Burden of Human Papillomavirus and Related Diseases, Molecular Pathogenesis, and Vaccine Evaluation. Front. Public Health. 2020; 8:552028. doi: 10.3389/fpubh.2020.552028
12. Ardekani A., Taherifard E., Mollalo A., Hemadi E., Roshanshad A., Fereidooni R., Rouholamin S., Rezaeinejad M., Farid-Mojtahedi M., Razavi M., and Rostami A. Human Papillomavirus Infection during Pregnancy and Childhood: A Comprehensive Review. Microorganisms. 2022 Oct; 10(10):1932. Published online 2022 Sep 28. doi: 10.3390/microorganisms10101932.
13. Ardekani A., Sepidarkish M., Mollalo A., Afradiasbagharani P., Rouholamin S., Rezaeinejad M., Farid-Mojtahedi M., Mahjour S., Almukhtar M., Nourollahpour Shiadeh M., et al. Worldwide prevalence of human papillomavirus among pregnant women: A systematic review and meta-analysis. Rev. Med. Virol. 2022:e2374. doi: 10.1002/rmv.2374.
14. Rombaldi R.L., Serafini E.P., Mandelli J., Zimmermann E., Losquiavo K.P. Transplacental transmission of Human Papillomavirus. Virol. J. 2008; 5:106. doi: 10.1186/1743-422X-5-106.
15. Trottier H., Mayrand M.H., Coutlйe F., Monnier P., Laporte L., Niyibizi J., Carceller A.M., Fraser W.D., Brassard P., Lacroix J., et al. Human papillomavirus (HPV) perinatal transmission and risk of HPV persistence among children: Design, methods and preliminary results of the HERITAGE study. Papillomavirus Res. 2016; 2:145—152. doi: 10.1016/j.pvr.2016.07.001.
16. Zouridis A., Kalampokas T., Panoulis K., Salakos N., Deligeoroglou E. Intrauterine HPV transmission: A systematic review of the literature. Arch. Gynecol. Obstet. 2018; 298:35—44. doi: 10.1007/s00404-018-4787-4.
17. Wang X., Zhu Q., Rao H. Maternal-fetal transmission of human papillomavirus. Chin. Med. J. 1998; 111:726—727.
18. Krasnopol'skiy V.I., Zarochentseva NV, Mikaelian AV, Keshchyan LV, Lazareva IN. Role of papillomavirus infection in pregnancy pathology and outcome for the newborn: Current ideas. Russian Bulletin of Obstetrician-Gynecologist. 2016;16(2):30-36. (In Russ.) doi.org/10.17116/rosakush201616230-36.
19. Zgura A.F., Bratila E., Vladareanu S. Transplacental Transmission of Human Papillomavirus. Maedica. 2015; 10:159—162.
20. Chatzistamatiou K., Sotiriadis A., Agorastos T. Effect of mode of delivery on vertical human papillomavirus transmission—A meta-analysis. J. Obstet. Gynaecol. 2016; 36:10—14. doi: 10.3109/01443615.2015.1030606.
21. Koskimaa H.M., Waterboer T., Pawlita M., Grйnman S., Syrjдnen K., Syrjдnen S. Human papillomavirus genotypes present in the oral mucosa of newborns and their concordance with maternal cervical human papillomavirus genotypes. J. Pediatr. 2012; 160:837—843. doi: 10.1016/j.jpeds.2011.10.027.
22. Castellsague X., Drudis T., Caсadas M.P., Goncй A., Ros R., Pйrez J.M., Quintana M.J., Muсoz J., Albero G., de Sanjosй S., et al. Human Papillomavirus (HPV) infection in pregnant women and mother-to-child transmission of genital HPV genotypes: A prospective study in Spain. BMC Infect. Dis. 2009; 9:74. doi: 10.1186/1471-2334-9-74.
23. Workowski K.A., Bolan G.A. Sexually transmitted diseases treatment guidelines. MMWR Recomm. Rep. 2015; 64:1—137.
24. Cunningham F.G., Leveno K.J., Bloom S.L., Dashe J.S., Hoffman B.L., Casey B.M., Spong C.Y. Williams Obstetrics. 25th ed. McGraw-Hill Education; New York, NY, USA: 2018. Neoplastic Disorders.
25. Silverberg MJ, Thorsen P, Lindeberg H, et al. Condyloma in pregnancy is strongly predictive of juvenile-onset recurrent respiratory papillomatosis. Obstet Gynecol 2003; 101:645—52.
26. Society C.P. Skin care for your baby. Paediatr. Child. Health. 2007; 12:245—251. doi: 10.1093/pch/12.3.245.
27. Petca A., Borislavschi A., Zvanca M.E., Petca R.C., Sandru F., Dumitrascu M.C. Non-sexual HPV transmission and role of vaccination for a better future (Review) Exp. Ther. Med. 2020; 20:186. doi: 10.3892/etm.2020.9316.
28. Benjamin L.T., Levy M., Ofori A. Condylomata Acuminata (Anogenital Warts) in Children. UpToDate; Waltham, MA, USA: 2014.
29. Casalegno JS, Le Bail Carval K, Eibach D, Valdeyron ML, Lamblin G, Jacquemoud H, Mellier G, Lina B, Gaucherand P, Mathevet P, et al. High risk HPV contamination of endocavity vaginal ultrasound probes: An underestimated route of nosocomial infection? PLoS One. 2012; 7(e48137) doi: 10.1371/journal.pone.0048137.
30. Gallay C, Miranda E, Schaefer S, Catarino R, Jacot-Guillarmod M, Menoud PA, Guerry F, Achtari C, Sahli R, Vassilakos P, et al. Human papillomavirus (HPV) contamination of gynaecological equipment. Sex Transm Infect. 2016; 92:19—23. doi: 10.1136/sextrans-2014-051977.
31. Meyers J, Ryndock E, Conway MJ, et al. Susceptibility of high-risk human papillomavirus type 16 to clinical disinfectants. J Antimicrob Chemother. 2014; 69:1546—50.
32. Syrjanen S., Puranen M. Human Papillomavirus Infections in Children: The Potential Role of Maternal Transmission. Crit. Rev. Oral Biol. Med. 2000;11:259—274. doi: 10.1177/10454411000110020801.
33. Sonnex C., Strauss S., Gray J.J. Detection of human papillomavirus DNA on the fingers of patients with genital warts. Sex. Transm. Infect. 1999; 75:317—319. doi: 10.1136/sti.75.5.317.
34. Tay SK, Ho TH, Lim-Tan SK. Is genital human papillomavirus infection always sexually transmitted? Aust NZJ Obstet Gynaecol. 1990; 30:240— 242. doi: 10.1111/j.1479-828x.1990.tb03223.x.
35. Mammas IN, Dalianis T, Doukas SG, Zaravinos A, Achtsidis V, Thiagarajan P, Theodoridou M, Spandidos DA. Paediatric virology and human papillomaviruses: An update. Exp Ther Med. 2019; 17:4337—4343. doi: 10.3892/etm.2019.7516.
36. Campbell C.M.P., Kreimer A.R., Lin H.Y., Fulp W., O’Keefe M.T., Ingles D.J., Abrahamsen M., Villa L.L., Lazcano-Ponce E., Giuliano A.R. Long-term persistence of oral human papillomavirus type 16: The HPV Infection in Men (HIM) study. Cancer Prev. Res. 2015; 8:190—196. doi: 10.1158/1940-6207.CAPR-14-0296.
37. Zhang L.-W., Wang W.-J., Li C.-H., Xu L., Liu X.-Y., Zheng L., Liu D.-X. A Case of Condyloma Acuminatum on the Nipple Detected via Dermoscopy. Int. J. Dermatol. Venereol. 2020; 3:125—126. doi: 10.1097/01.JD9.0000563564.57133.50.
38. Saeki Y., Sato S., Okajima K., Ando N., Saeki H., Kawase M., Ito K., Nakagawa H., Ohtsuki M. Condyloma acuminatum of the nipple and areola. Int.J. Dermatol. 2014; 53:e171—e172. doi: 10.1111/j.1365-4632.2012.05727.x.
39. Syrjänen S., Waterboer T., Rintala M., Pawlita M., Syrjänen K., Louvanto K., Grenman S. Maternal HPV-antibodies and seroconversion to HPV in children during the first 3 years of life. Sci. Rep. 2022; 12:2227. doi: 10.1038/s41598-022-06343-z.
40. Cason J., Mant C.A. High-risk mucosal human papillomavirus infections during infancy & childhood. J. Clin. Virol. 2005; 32(Suppl. S1):S52—S58. doi: 10.1016/j.jcv.2004.12.007.
Review
For citations:
Karachentsova I.V., Sibirskaya E.V., Denisovets V.M., Chernysheva M.Y., Nurmatova A.F. Mechanisms of HPV transmission among girls of different ages. CHILDREN INFECTIONS. 2025;24(1):37-42. (In Russ.) https://doi.org/10.22627/2072-8107-2025-24-1-37-42
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