АНТИБИОТИКО-АССОЦИИРОВАННЫЕ ДИАРЕИ И CL. DIFFICILE-ИНФЕКЦИЯ У ДЕТЕЙ: ФАКТОРЫ РИСКА
https://doi.org/10.22627/2072-8107-2015-14-2-30-34
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Аннотация
В обзоре литературы представлены данные о частоте развития и особенностях течения антибиотико-ассоциированных диарей (ААД) у детей. Изложены материалы исследований отечественных и зарубежных ученых о факторах риска активации токсигенных штаммов Cl. difficile, показана связь между глубиной микроэкологических метаболомных нарушений и Cl. difficile-инфекцией у детей.
Об авторах
Л. Н. Мазанкова
ГБОУ ДПО Российская медицинская академия последипломного образования МЗ РФ, кафедра детских инфекционных болезней, Москва
Россия
д.м.н., проф., зав. каф. детских инфекционных болезней ГБОУ ДПО РМАПО МЗ РФ; 125373, г. Москва, ул. Героев Панфиловцев, д.28; +7 (495) 949-17-22
Россия
д.м.н., проф., зав. каф. детских инфекционных болезней ГБОУ ДПО РМАПО МЗ РФ; 125373, г. Москва, ул. Героев Панфиловцев, д.28; +7 (495) 949-17-22
С. Г. Перловская
ГБУЗ Детская городская клиническая больница № 9 им. Г.Н. Сперанского ДЗМ
Россия
Россия
Список литературы
1. Баранов А.А. Применение антибиотиков у детей в амбулаторной практике. Методические рекомендации /А.А. Баранов, Л.С. Страчунский // Клиническая микробиология и антимикробная химиотерапия. - 2007. - № 9 (3). - С. 200-210. Baranov A.A., Strachunskiy L.S. [Antibiotics use in children in outpatient practice] / Metodic recommendations // Clinical Microbiology and Antimicrobial Chemotherapy. - 2007. - 9 (3) : S. 200-210. (In Russ)
2. Sommet A., Sermet C., Boelle P.Y., Tafflet M., Bernède C. et al. (2004) No significant decrease in antibiotic use from 1992 to 2000, in the French community // J. Antimicrob Chemother 54 : 524-528.
3. Бельмер С.В. Антибиотик-ассоциированный дисбактериоз кишечника // РМЖ. - 2004. - Т. 12 : 3. - С. 148-151. Belmer S.V. Antibiotic-associated intestinal dysbacteriosis // RMJ. - 2004. - 12 (3) : 148-151. (In Russ)
4. Turke D., Bernet J. P., Marx J., Kemph H., Giard P., Welbaum O. et al. Incidence and risk factors of oral antibiotic-associated diarrhea in an outpatient pediatric population // J. Pediatr Gastroenterol Nutr. - 2003. - 37 : 22-26.
5. Alam S., Muchataq M. Antibiotic associated diarrhea in children. // Indian Pediatr. - 2009. - Jun. - 46 (6) : 491-6.
6. Damrongmanee A., Ukarapol N., 2000: Incidence of antibiotic-associated diarrhea in a pediatric ambulatory care setting // J of the Med Assoc of Thailand. - 90 (3) : 513-517.
7. Hogenauer C., Hammer H.F., Krejs G.J., Reisinger E.C. Mechanisms and management of antibiotic - associated diarrhea // Clin. Infect. Dis. - 1998. - 27 : 702-10.
8. Hogenauer C., Langner C., Beubler E. et al. Klebsiella oxytoca as a causative organism of antibiotic-associated hemorrhagic colitis // NEngl J. Med. - 2006. - 355 : 2418-26.
9. C. Hogenauer et al. Klebsiella oxytoca as a Causative Organism of Antibiotic-Associated Hemorrhagic Colitis // N Engl J. Med. Dec. - 7. - 2006. - 355 : 2418-26.
10. Лобзин Ю.В. Современные представления об инфекции Clostridium difficile / Ю.В. Лобзин, С.М. Захаренко, Г.А. Иванов // Клиническая микробиология и антимикробная химиотерапия. - 2002. - № 3. - Т. 4. - С. 200-232. Yu.V. Lobzin, S.M. Zakharenko, G.A. Ivanov. [Current Understanding of Clostridium difficile Infection] // Clin. Microb. and Antimicrob. Chemoth. - 2002. - № 3. - V. 4. - S. 200-232. (In Russ)
11. Bose S., Han K.W., Lee M.J., Kim H. (2013) Intestinal Protective Effects of Herbal-Based Formulations in Rats against Neomycin Insult. // Evid Based Complement Alternat Med. - 2013 : 161278
12. Малов В.А. Антибиотикоассоцированные диареи // Клиническая микробиология и антимикробная химиотерапия. - 2002. - № 1. - Т. 4. - С. 22-32. Malov V.A. [Antibiotic-Associated Diarrhea] // Clin. Microb. and Antimicrob. Chemoth. - 2002. - № 1. - V. 4. - S. 22-32. (In Russ)
13. David M.S., Donald H.A., Fabio B. Association Between Antibiotic Use and Primary Idiopathic Intussusception // Arch. Pediatr. Adolesc. Med. - 2003. - Suppl. 157 (1). - P. 54-59.
14. Acar J.F. A comparison of side effects of levofloxacin to other agents concerning the ecological and microbiological effects on normal human flora // Chemotherapy 2001. - 47 (3) : 15-23.
15. Бондаренко В.М. Метаболитные пробиотики: механизмы тера-певтического эффекта при микроэкологических нарушениях // Consilium Medicum. Гастроэнтерология. - 2005. - № 6. - Т. 7. - С. 437-443. Bondarenko V.M. [Metabolic probiotics: mechanisms of therapeutic effect in microecological disorders] // Consilium Medicum. Gastroenterology. - 2005. - № 6 (7). - S. 437-43. (In Russ)
16. Ардатская М.Д. Дисбактериозы кишечника: эволюция взглядов, cовременные принципы диагностики и фармакологическои коррекции / М.Д. Ардатская, О.Н. Минушкин // Consilium Medicum. Гастроэнтерология. - 2006. - № 2. - С. 4-17. Ardatskaya M.D., Minushkin O.N. [Dysbacteriosis of the intestine: evolution of views, modern principles of diagnosis and pharmacological correction] // Consilium Medicum. Gastroenterology. - 2006. - № 2. - S. 4-17. (In Russ)
17. M. Barakat, Z. El-Kady, M. Mostafa, N. Ibrahim, H. Ghazaly. Antibiotic-associated bloody diarrhea in infants: clinical, endoscopic, and histopathologic profiles // J. of Ped Gastroent and Nutr. - 52 (1). - 60-64.
18. Sparks S., Carman R.J., Sarker M., McLane B. Genotyping of enterotoxigenic Clostridium perfringens fecal isolates associated with antibiotic-associated diarrhea and food poisoning in North America // J Clin Microbiol. - 2001. - 39 (3) : 883-8.
19. Zollner-Schwetz I. et al. - 2008. Role of Klebsiella oxytoca in antibiotic-associated diarrhea // Clin. Infect. Dis. - 47: e74-e78.
20. Hoffmann K.M. et al. 2010. Antibiotic-associated hemorrhagic colitis caused by cytotoxin-producing Klebsiella oxytoca // Pediatrics. - 125: e960-e963.
21. Krause R., Schwab E., Bachhiesl D., Daxböck F., Wenisch C., Krejs G.J., Reisinger E.C. Role of Candida in antibiotic-associated diarrhea // J Infect Dis. - 2001. - Oct. 15. - 184 (8) : 1065-9. - Epub. - 2001. - Aug 31.
22. Krause R., Krejs G., Wenisch C., Reisinger E.C. Elevated fecal Candida counts in patients with antibiotic-associated diarrhea: role of soluble fecal substances // Clin and Diagn Lab Immunol. - 2003. - V. 10 (1). - 167-168.
23. Thomas C., Stevenson M., Riley T.V. (2003). Antibiotics and hospital acquired Clostridium difficile-associated diarrhoea: a systematic review of published epidemiological studies // J. of Antimic Chemoth. - 51 (6). - 1339-1350.
24. Захарова И.Н. Антибиотик-ассоциированные диареи у детей: проблема и решение. Учебное пособие для врачей / И.Н. Захарова, Л.Н. Мазанкова. - М., 2011. - 48 c. Zaharova I.N., Mazankova L.N. [Antibiotic-associated diarrhea in children the problem and the solution] (training manual for doctors). - Moscow. - 2011. - 48 s. (In Russ)
25. Захаренко С.М. Заболевания, ассоциированные с Clostridium difficile / С.М. Захаренко, С.В. Пономарев // Лечение и профилактика. - 2012. - № 3. - С. 82-89. Zakharenko S.M., Ponomarev S.V. [The diseases associated with Clostridium difficile] // Treatment and Prevention. - 2012. - № 3. - S. 82-89. (In Russ)
26. Britton R.A., Young V.B. 2012. Interaction between the intestinal micro-biota and host in Clostridium difficile colonization resistance // Trends Microbiol. - 20 : 313-319.
27. Kelly C.P., Kyne L. 2011. The host immune response to Clostridium difficile. // J. Med. Microbiol. - 60 : 1070-1079.
28. Loo V.G. et all. 2011. Host and pathogen factors for Clostridium difficile infection and colonization // N. Engl. J. Med. - 365 : 1693- 1703.
29. Morinville V., McDonald J. (2005) Clostridium difficile - associated diarrhea in 200 Canadian children // Can J Gastroenterol. - 19 (8) : 497-501.
30. Spivack J.G., Eppes S.C., Klein J.D. (2003) Clostridium difficile associated diarrhea in a pediatric hospital // Clin Pediatr (Phila). - 42 (4) : 347-52.
31. Klein E.J., Boster D.R., Stapp J.R., Wells J.G., Qin X. et al. (2006) Diarrhea etiology in a Children's Hospital Emergency Department: a prospective cohort study // Clin Infect Dis. - 43 (7) : 807-13.
32. Rupnik M., Wilcox M.H., Gerding D.N. (2009) Clostridium difficile infection: new developments in epidemiology and pathogenesis // Nature. - 7 : 526-36.
33. Dethlefsen L., Huse S., Sogin M.L., Relman D.A. 2008. The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing // PLoS Biol. - 6:e280. https://doi.org/10.1371/ journal.pbio. - 0060280.
34. Bartlett J.G. Clostridium difficile: progress and challenges // Ann N. Y. Acad Sci. - 2010. - 1213 : 62-69.
35. Denève C., Bouttier S., Dupuy B., Barbut F., Collignon A., Janoir C. Effects of subinhibitory concentrations of antibiotics on colonization factor expression by moxifloxacin-susceptible and moxifloxacin-resistant Clostridium difficile strains // Antimicrob Agents Chemother. - 2009. - Dec. - 53 (12) : 5155-62.
36. Razaq N. et al. Infection of hamsters with historical and epidemic BI types of Clostridium difficile // J. Infect Dis. - 2007. - 196 : 1813- 1819.
37. Stevens V. et al. Cumulative antibiotic exposures over time and the risk of Clostridium difficile infection // Clin Infect Dis. - 2011. - 53 : 42-48.
38. Юнес Б. Роль Clostrdium difficile в формировании антибиотик-ассоциированной диареи у детей: Автореф. ... к.м.н. - М., 2013. - 25 c. Yunes B. [Role Clostrdium difficile in the formation of antibiotic-associated diarrhea in children] (abstract). - M., 2013. - 25 s. (In Russ)
39. Paterson D.L. Collateral damage» from cephalosporin or quinolone antibiotic therapy // Clin Infect Dis. - 2004. - 38 (Suppl 4). - S. 341-345.
40. Reeves A.E. et al. The interplay between microbiome dynamics and pathogen dynamics in a murine model of Clostridium difficile Infection // Gut Microbes. - 2011. - 2 : 145-158.
41. Rea M.C. et al. Microbes and Health Sackler Colloquium: Effect of broad- and narrow-spectrum antimicrobials on Clostridium difficile and microbial diversity in a model of the distal colon // Proc Natl Acad Sci USA. - 2010.
42. Theriot C.M., Koenigsknecht M.J., Carlson P.E. Jr, Hatton G.E., Nelson A.M., Li B., Huffnagle G.B., Z Li J., Young V.B. Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection // Nat Commun. - 2014. - 5 : 3114.
43. Dethlefsen L., Relman D.A. 2011. Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation // Proc. Natl. Acad. Sci. U.S.A. - 108 (Suppl 1) : 4554-4561.
44. Gough E., Shaikh H., Manges A. R. 2011. Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium difficile infection // Clin. Infect. Dis. - 53 : 994-1002.
45. Van Nood E et al. 2013. Duodenal infusion of donor feces for recurrent Clostridium difficile // N. Engl. J. Med. - 368 : 407-415.
46. Maribeth R. Nicholson, Isaac P. Thomsen and Kathryn M. Edwards. Controversies Surrounding Clostridium difficile Infection in Infants and Young Children // Children. - 2014. - 1 (1). - 40-47.
47. Jarchum I. et al. Toll-like receptor-5 stimulation protects mice from acute Clostridium difficile colitis // Infect Immun. - 2011. - 79 : 1498-1503.
48. Pai S., Aliyu S.H., Enoch D.A., Karas J.A. Five years experience of Clostridium difficile infection in children at a UK tertiary hospital: proposed criteria for diagnosis and management // PLoS One. - 2012. - 7 (12): e51728.
49. Kim J., Smathers S.A., Prasad P. et al. Epidemiological features of Clostridium difficile-associated disease among inpatients at children's hospitals in the United States. - 2001-2006 // Pediatrics. - 2008. - 122 : 1266-1270.
50. Adlerbertha I., Huangb H., Lindberga E. et al. Toxin-Producing Clostridium difficile Strains as Long-Term Gut Colonizers in Healthy Infants // J. Clin. Microbiol. January. - 2014. - V. 52. - № 1. - 173-179.
51. Jangi S., Lamont J.T. 2010. Asymptomatic colonization by Clostridium difficile in infants: implications for disease in later life // J. Pediatr. Gastroenterol. - Nutr. 51:. - 2-7.
52. Magnusson C., Wullt M., Löfgren S., Iveroth P., Akerlund T., Matussek A. 2013. Ribotyping of Clostridium difficile strains associated with no-socomial transmission and relapses in a Swedish county // APMIS. - 121 : 153-157.
53. Bauer M.P., Notermans D.W., van Benthem B.H., Brazier J.S., Wilcox M.H., Rupnik M., Monnet D.L., van Dissel J.T., Kuijper E.J., ECDIS Study Group. - 2011. Clostridium difficile infection in Europe: a hospital-based survey // Lancet. - 377 : 63-73.
54. Khanna S. et all. The epidemiology of Clostridium difficile infection in children: a population-based study // Clin Infect Dis. - 2013. - May 56 (10) : 1401-6.
55. Penders J., Thijs C., Van den Brandt P. A., Kummeling I., Snijders B. et al. (2007) Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study // Gut. - 56 : 661-7.
56. Matsuki S., Ozaki E., Shozu M. et al. Colonization by Clostridium difficile of neonates in a hospital, and infants and children in three daycare facilities of Kanazawa, Japan // Int Microbiol. - 2005. - 8 : 43-48.
57. Rousseau C. et al. Clostridium difficile colonization in early infancy is accompanied by changes in intestinal microbiota composition // J. Clin Microbiol. - 49 : 858-865 (2011).
58. Ling Z. et al. Pyrosequencing analysis of the human microbiota of healthy Chinese undergraduates // BMC Genomics. - 14.: 390 (2013).
59. Mariat D. et al. The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age // BMC Microbiol. - 9 : 123 (2009).
60. Ling Z., Liu X., Jia X., Cheng Y. at all. 2014. Impacts of infection with different toxigenic Clostridium difficile strains on faecal microbiota in children // Sci Rep. - 2014. - Dec 15. -4 : 7485.
61. Tonooka T., Sakata S., Kitahara M. et al. Detection and quantification of four species of the genus Clostridium in infant feces // Microbiol Immunol. - 2005. - 49 : 987-992.
62. Щеплягина Л.А. Секреторный иммунитет кишечника у детей ран-него возраста / Л.А. Щеплягина, И.В. Круглова, В.А. Перцева // Педиатрия. - 2011. - № 3. - С. 48-50. Sheplygina L.A., Kruglova V.I., Pertseva V.A. [The secretory immune system of the intestine in children of early age] // Pediatrics. - 2011. - № 3. - S 48-50. (In Russ)
63. Penders J., Vink C., Driessen C. et al. Quantification of Bifidobacteri-um spp., Escherichia coli and Clostridium difficile in faecal samples of breast-fed and formula-fed infants by real-time PCR.// FEMS Micro-biol Lett. - 2005. - 243 : 141-147.
64. Hopkins M.J., Macfarlane G.T. 2002. Changes in predominant bacterial populations in human faeces with age and with Clostridium difficile infection // J. Med. Microbiol. - 51 : 448-454.
65. Эпидемиология и клинические варианты Clostridium difficile-инфекции у детей / Л.Н. Мазанкова, Б. Юнес, С.Г. Горбунов, И.С. Курох-тина // Детские инфекции. - 2012. - № 3. - С. 39-42. Mazankova L.N., Yunes В., Gorbunov S.G., Kurokhtina I.S. [Epidemiology and clinical variants of Clostridium difficile infection on the background of antimicrobial therapy in children] // Children Infections. - 2012. - № 3. - S. 39-42. (In Russ)
66. Bossuyt P., Verhaegen J., Van Assche G., Rutgeerts P., Vermeire S. Increasing incidence of clostridium difficile-associated diarrhea in inflammatory bowel disease // J. Crohn’s Colitis. - 2009. - 3 : 4-7.
67. Parsons S.J., Fenton E., Dargaville P. Clostridium difficile associated severe enterocolitis: a feature of Hirschsprung's disease in a neonate presenting late // J. of paed and child health. - 41 : 12. - 2005. - Dec. - Pg 689-90.
68. El-Mahallawy H.A., El-Din N.H., Salah F., El-Arousy M., El-Naga S. A. (2004) Epidemiologic profile of symptomatic gastroenteritis in pediatric oncology patients receiving chemotherapy // Pediatr Blood Cancer. - 42 (4) : 338-42.
69. Castagnola E., Battaglia T., Bandettini R., Caviglia I., Baldelli I. et al (2009) Clostridium difficile - associated disease in children with solid tumors // Support Care Cancer. - 17 (3) : 321-4.
70. Simon A., Fleischhack G., Hasan C., Bode U., Engelhart S. et al. (2000) Surveillance for nosocomial and central line related infections among pediatric hematologyoncology patients // Infect Control Hosp Epidemiol. - 21 (9) : 592-596.
Рецензия
Для цитирования:
Мазанкова Л.Н., Перловская С.Г. АНТИБИОТИКО-АССОЦИИРОВАННЫЕ ДИАРЕИ И CL. DIFFICILE-ИНФЕКЦИЯ У ДЕТЕЙ: ФАКТОРЫ РИСКА. ДЕТСКИЕ ИНФЕКЦИИ. 2015;14(2):29-34. https://doi.org/10.22627/2072-8107-2015-14-2-30-34
For citation:
Mazankova L.N., Perlovskaya S.G. ANTIBIOTIC-ASSOCIATED DIARRHEA AND CL. DIFFICILE-INFECTION IN CHILDREN: RISK FACTORS. CHILDREN INFECTIONS. 2015;14(2):29-34. (In Russ.) https://doi.org/10.22627/2072-8107-2015-14-2-30-34
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ISSN 2072-8107 (Print)
ISSN 2618-8139 (Online)
ISSN 2618-8139 (Online)
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