CLINICAL FEATURES OF REFRACTORY FORMS OF ANEMIA IN CHILDREN WITH CHRONIC HEPATITIS В
https://doi.org/10.22627/2072-8107-2013-12-3-15-19
Abstract
Examination of 125 children with chronic hepatitis В and concomitant anemia has determined the frequency of refractory forms of anemia (52,5%). The disease progressed more severely on the background of anemia, which was indicated by the prevalence of CHВ forms with severe activity (71,4%). The pathognomonic symptoms of anemic processes were revealed. Two pathogenetic variants of the anemia genesis in children with CHВ are being considered: the first is defined by veritable iron deficiency with ferrokinetic markers of iron-deficiency anemia; the second — by relocationable iron deficit that is typical for hemosiderosis and refractoriness development.
About the Authors
F. I. Inoyаtova
Specialized Scientific Practical Medical Center of Pediatrics of the Republic of Uzbekistan, Tashkent
Uzbekistan
Uzbekistan
G. Z. Inogamova
Specialized Scientific Practical Medical Center of Pediatrics of the Republic of Uzbekistan, Tashkent
Uzbekistan
Uzbekistan
Sh. Yu. Abdumadjidova
Specialized Scientific Practical Medical Center of Pediatrics of the Republic of Uzbekistan, Tashkent
Uzbekistan
Uzbekistan
A. Kh. Akhmedova
Specialized Scientific Practical Medical Center of Pediatrics of the Republic of Uzbekistan, Tashkent
Uzbekistan
Uzbekistan
N. K. Valieva
Specialized Scientific Practical Medical Center of Pediatrics of the Republic of Uzbekistan, Tashkent
Uzbekistan
Uzbekistan
F. G. Abdullaeva
Specialized Scientific Practical Medical Center of Pediatrics of the Republic of Uzbekistan, Tashkent
Uzbekistan
Uzbekistan
V. I. Sabitova
Specialized Scientific Practical Medical Center of Pediatrics of the Republic of Uzbekistan, Tashkent
Uzbekistan
Uzbekistan
N. A. Ikramova
Specialized Scientific Practical Medical Center of Pediatrics of the Republic of Uzbekistan, Tashkent
Russian Federation
Russian Federation
F. R. Muzaffarova
Specialized Scientific Practical Medical Center of Pediatrics of the Republic of Uzbekistan, Tashkent
Uzbekistan
Uzbekistan
References
1. Учайкин В.Ф., Чередниченко Т.В., Смирнов А.В. Инфекционная гепатология: Монография. — ГЕОТАР-медиа: Москва, 2012. — 640 с.
2. WHO/UNISEF/ UNU. Iron Deficiency Anemia: Assessment, Prevention, and Control. — Copenhagen, 2005. — Р. 114.
3. Иноятова Ф.И. Хронические вирусные гепатитыу детей: Монография. — Ибн Сино: Ташкент, 1997. — 102 с.
4. Козловская Л.В., Рамеев В.В., Саркисова И.А. Патогенез и клиническое значение анемии хронических заболеваний // Анемия. — 2005. — № 4. — С. 4—10.
5. Железодефицитная анемия у детей с патологией органов пищеварения / Волынец Г.В., Хавкин А.И., Бабаян М.Л. и др. // РМЖ. — 2004. — № 3. — С. 12—20.
6. Ozatli D. Erythrocytes: Anemias in Chronic Liver Diseases // Hematology. — 2000. —№ 5. — Р. 69—76.
7. Гепсидин как регулятор гомеостаза железа / Левина А.А., Казюкова Т.В., Цветаева Н.В. и др. // Педиатрия. — 2008. — Т. 87. — № 1. — С. 67—74.
8. Hepcidin, a key regulator of iron metabolism, is transcriptionally activated by p53 / Weizer-Stern O., Adamsky K., Margalit O. et al. // Вr. J. Haemotol. — 2007. — № 2. — P. 253—262.
9. Hepcidin in iron overload disorders / Papnicolaou G., Tzilianos M., Christakis J. et al. // Blood. — 2005. — V. 105. — P. 4103— 4105.
10. Маянский Н.А., Семикина Е.Л. Гепцидин: основной регулятор и новый диагностический маркер // Вопросы диагностики в педиатрии. — 2009. — Т. 1. — № 1. — С. 18—23.
11. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression / Babitt J.L., Huang F.., Wrighting D.M. et al. // Nat. Genet. — 2006. — № 5. — P. 531—539.
Review
For citations:
Inoyаtova F.I., Inogamova G.Z., Abdumadjidova Sh.Yu., Akhmedova A.Kh., Valieva N.K., Abdullaeva F.G., Sabitova V.I., Ikramova N.A., Muzaffarova F.R. CLINICAL FEATURES OF REFRACTORY FORMS OF ANEMIA IN CHILDREN WITH CHRONIC HEPATITIS В. CHILDREN INFECTIONS. 2013;12(3):15-19. (In Russ.) https://doi.org/10.22627/2072-8107-2013-12-3-15-19
Views:
755
Email this article 