Respiratory Syncytial Virus Lower Respiratory Tract Infections in Premature Infants and Infants with Bronchopulmonary Dysplasia

The article is devoted to the study of features of lower respiratory tract infection associated with respiratory syncytial virus. 40 cases of RSV-bronchiolitis in preterm children under year with/without bronchopulmonary dysplasia were analyzed. It was established that disease in those groups of patients had severe course because of the respiratory failure, which dominates in clinical pictures as symptoms of bronchial obstruction and apnea. Treatment of severe RSV-infection often demand admission to intensive care unit, supplemental oxygen and/or mechanical ventilation.

1. Nair H., Nokes D.J., Gessner B.D., Dherani M. et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis // Lancet. 2010; 375(9725):1545—55.

2. Fleming D.M., Pannell R.S., Cross K.W. Mortality in children from influenza and respiratory syncytial virus // Journal of Epidemiology and Community Health. 2005; 59(7):586—90.

3. Shay D.K., Holman R.C., Roosevelt G.E., Clarke M.J. et.al. Bronchiolitis-associated mortality and estimates of respiratory syncytial virus-associated deaths among US сhildren, 1979—1997 // Journal of Infectious Diseases. 2001; 183(1):16—22.

4. Thompson W.W., Shay D.K., Weintraub E., Brammer L., et al. Mortality associated with influenza and respiratory syncytial virus in the United States // JAMA. 2003; 289(2):179—86.

5. American Academy of Pediatrics, Committee on Infectious Diseases and Committee on Fetus and Newborn.Policy statement-modified recommendations for use of palivizumab for prevention of respiratory syncytial virus infections // Pediatrics. 2009; 124(6):1694— 701.

6. Hall C.B., Walsh E.E. Respiratory syncytial virus. In: Feigin R.D., et al. editor(s). Feigin and Cherry’s Textbook of Pediatric Infectious Diseases. 6th Edition. Vol. 2, Philadelphia:Saunders Elsevier, 2009:2462—87.

7. Simoes E.A., Carbonell-Estrany X . Impact of severe disease caused by respiratory syncytial virus in children living indeveloped countries // Pediatric Infectious Disease Journal. 2003; 22(Suppl 2):13—8.

8. American Academy of Pediatrics. Respiratory syncytial virus. In: Pickering LK editor(s). Red Book: 2012 Report of the Committee on Infectious Diseases. 29th Edition. Elk Grove Village: Churchill Livingstone, 2012:609—18.

9. Shay D.K., Holman R.C., Newman R.D., et al. Bronchiolitis-associated hospitalizations among US children, 1980—1996 // JAMA. 1999; 282: 440-6.

10. Arms J.L., Ortega H., Reid S. Chronological and clinical characteristics of apnea associated with respiratory syncytial virus infection: a retrospective case series // Clinical Pediatrics. 2008; 47(9):953—8.

11. Hall C.B., Hall W.J., Speers D.M. Clinical and physiological manifestations of bronchiolitis and pneumonia. Outcome of respiratory syncytial virus // American Journal of Diseases of Children. 1979; 133(8):798—802.

12. Ralston S., Hill V. Incidence of apnea in infants hospitalized with respiratory syncytial virus bronchiolitis: a systematic review // Journal of Pediatrics. 2009; 155(5):728—33.

13. Дементьева Г.М. Клинико-патогенетическая характеристика и критерии задержки роста и развития у новорожденных: Авто-реф. дис. … д-ра мед. наук. — М., 1984. 43 c. Dementyeva G.M. [Clinical and pathogenetic characteristics and criteria of delayed growth and development in infants]: Avtoref. dis. … d-r med. scien. — M., 1984. 43 c. (in Russ).

14. Gorelick M.H., Singh B.S. Неотложные состояния при патологии дыхательной системы. Секреты неотложной педиатрии / С.М. Селбст, К. Кронэн; Пер. с англ. Под ред.Н. П. Шабалова. — М.: МЕДпресс-информ, 2006: 277—291.

15. Gorelick M.H., Singh B.S. [Emergency conditions in the pathology of the respiratory system. Secrets of emergency pediatrics] / S.M. Selbst, K. Kronen; Transl. ed. by N.P. Shabalov. — M.: MEDpress-inform, 2006: 277—291. (in Russ).

16. Hall C.B., Douglas R.G., Geiman J.M., Messner M.K. Nosocomial respiratory syncytialvirusinfections // N. Engl. J. Med. 1975; 293:1343—1346.

17. Hall C.B. Respirtory syncytial virus: What we know now // Contemp. Pediatr. 1994; 10: 92—110.

18. Silva C., Dias L., Baltieri S. et al. Respiratory syncytial virus outbreak in neonatal intensive care unit: Impact of infection control measures plus palivizumab use //Antimicrob. Resist. Infect. Control. 2012; doi:10.1186/2047-2994-1-16.

19. O'Connell K., Boo T.W., Keady D., et al. Use of palivizumab and infection control measures to control an outbreak of respiratory syncytial virus in a neonatal intensive care unit confirmed by real-time polymerase chain reaction //J. Hosp. Infect. 2011; 77: 338–342.

20. Tatochenko V., Uchaikin V., Gorelov A. et al. Epidemiology of respiratory syncytial virus in children ≤ 2 years of age hospitalized with lower respiratory tract infections in the Russian Federation: a prospective, multicenter study // Clinical Epidemiology. 2010, October 21; 2:221—227.

21. Овсянников Д.Ю. Острый бронхиолит у детей //Вопр. практич. педиатрии. 2010; 5 (2): 75—84. Ovsyannikov D.U. [Acute bronchiolitis in children] // Voprоsi Prakticheskoy Pediatrii. 2010; 5 (2): 75—84. (in Russ).

22. Purcell K, Fergie J. Concurrent serious bacterial infections in 2396 infants and children hospitalized with respiratory syncytial virus lower respiratory tract infections // Pediatr Infect Dis J. 2007; 26(4):311—315.

23. Баральди Е.,Занконато С.,Карраро С. Бронхиолит: от эмпиризма до научных доказательств //Лечащий врач. 2011; 6:12—20. Baraldi E., Zankonato S., Karraro S. Bronhiolit: ot empirizma do nauchnyih dokazatelstv. [Bronchiolitis: from empiricism to scientific proof] // Lechaschiy Vrach. 2011; 6:12—20 (in Russ).