Dynamics of CD4 Lymphocytes and Viral Load at the Natural History of Perinatal HIV-infection
https://doi.org/10.22627/2072-8107-2015-14-3-26-29
Abstract
This article presents the analysis of indicators of CD4 lymphocyte count and viral load in the natural history (in the absence of ART) in perinatally HIV-infected children. It was revealed that perinatal way of transmission is characterized by a higher rate of immunodeficiency progression. It may be associated with intrauterine infection, as well as an early defeat HIV immature immune system of the child. The concentration of virus in perinatally infected children since the beginning of the observation and in 30 months after infection is more than in parenterally infected children in 5 and 2 times, respectively, which determines a infavourable version of the disease in perinatally infected children.
About the Authors
T. A. Daminov
Tashkent Medical Academy Ministry of Health of the Republic of Uzbekistan
Russian Federation
Russian Federation
L. N. Tuychiev
Tashkent Medical Academy Ministry of Health of the Republic of Uzbekistan
Russian Federation
Russian Federation
G. K. Khudaykulova
Tashkent Medical Academy Ministry of Health of the Republic of Uzbekistan
Russian Federation
Russian Federation
PhD, associate professor of the department of infectious and pediatric infectious diseases, Tashkent Medical Academy.
Address: Uzbekistan, Tashkent city, Farobi str, 2. Tel.: +99890) 948-45-90;
References
1. Петрова А.Г. Клинико-иммунологические аспекты перинатальной ВИЧ-инфекции у детей — оптимизация диагностики, лечения и реабилитации: Автореф. дисс. ... д.м.н. — Красноярск, 2008. Petrova A.G. Kliniko-immunologicheskie aspektyi perinatalnoy VIChinfektsii u detey — optimizatsiya diagnostiki, lecheniya i reabilitatsii : [Clinical and immunological aspects of perinatal HIV infection in children — optimization of diagnosis, treatment and rehabilitation] Avtoref. Dissert. ... doktora meditsinskih nauk. — Krasnoyarsk, 2008. (In Russ.)
2. Белозеров Е.С. ВИЧ-инфекция / Е.С. Белозеров, Ю.И. Буланьков. — Элиста: Джангар, 2006. 224 с. Belozerov E.S. [VICh-infektsiya [HIV ] / E.S. Belozerov, Yu.I. Bulankov. — Elista: Dzhangar, 2006. 224 s. (In Russ.)
3. ВИЧ-инфекция и СПИД / под ред. В.В. Покровского. — М.: ГЭОТАР-Медиа, 2006. — 128 с. VICh-infektsiya i SPID [HIV and AIDS] / pod red. V.V. Pokrovskogo. — M.: GEOTAR-Media, 2006. — 128 s. (In Russ.)
4. Abrams E.J. Pediatric HIV infection / E.J Abrams, S.W. Nicholas // Pediatr. Ann. 1990. — Vol. 19, № 8. — P. 482—487.
5. Barnhart H.X. Natural history of HIV disease in perinatally infected children: an analysis from the Pediatric Spectrum of Disease Project / H.X. Barnhart, M.B. Caldwell, P. Thomas et al. // Pediatrics, 1996. Vol. 97. — 710—716.
6. Age- and time-related changes in extracellular viral load in children vertically infected by HIV / K. Mcintosh, A. Shevitz, D. Zaknun et al. // Pediatr. Infect. Dis. J. — 1996. — Vol. 15. — P. 1087—1091.
7. Dynamics of viral replication in infants with vertically acquired human immunodeficiency virus type 1 infection / A. De Rossi, S. Masiero, C. Giaquinto, et al. // J. Clin. Inves. 1996. — Vol. 97, № 2. — P. 323—330.
8. Dunn D; HIV Paediatric Prognostic Markers Collaborative Study Group. Short-term risk of disease progression in HIV-1-infected children receiving no antiretroviral therapy or zidovudinemonotherapy: a meta-analysis // Lancet. 2003; 362:1605—11.
9. Raquenaud M. et al. Excellent outcomes among HIV+ children on ART, but unacceptably high pre-ART mortality and losses to followup: a cohort study from Cambodia // BMCPediatric. 2009; 9:54.
10. Shearer W.T., Quinn T.C., LaRussa P. et al. Viral load and disease progression in infants infected with human immunodeficiency virus type 1. Women and infants Transmission Study Group // NEJM. 1997; 336:1337—1342.
11. DouekD.C., PickerL.J., KoupR.A. TcelldynamicsinHIV-1 infection // Annu. Rev. Immunol. 2003; 21:265—304.
12. Essajee S.M., Pollack H., Rochford G. et al. Early changes in quasispecies repertoire in HIV-infected infants: correlation with disease progression // AIDS Res. Human Retroviruses. 2000; 16:18: 1949—1957.
13. Goulder P.J., Brander C., Tang Y. et al. Evolution and transmission of stable CTL escape mutations in HIV infection // Nature. 2001; 412:6844:334—338.
Review
For citations:
Daminov T.A., Tuychiev L.N., Khudaykulova G.K. Dynamics of CD4 Lymphocytes and Viral Load at the Natural History of Perinatal HIV-infection. CHILDREN INFECTIONS. 2015;14(3):26-29. (In Russ.) https://doi.org/10.22627/2072-8107-2015-14-3-26-29
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