Health-related quality of life in patients with chronic hepatitis C during combined antiviral therapy
https://doi.org/10.22627/2072-8107-2019-18-4-38-42
Abstract
Assessment of health-related quality of life in patients with chronic hepatitis C, as a technique for determining the tolerability of complex antiviral therapy.
Methods: а comprehensive examination of 106 patients with a diagnosis of chronic hepatitis C was performed before and after the end of the combination antiviral therapy.
Results of the study: after therapy on all scales of the physical component of health, higher rates were observed in men. Significantly differences (p < 0.05) were obtained in the following areas: physical functioning (PF), role-based functioning due to physical condition (RP) and general health status (GH). According to the scales of the mental component of health, the indicators of quality of life in men also exceed the obtained values in women, however, significant differences (p < 0.05) are established only on the scale of role-based functioning due to the emotional state (RE).
About the Authors
V. L. Rozina
Yaroslavl State Medical University of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Varvara Rozina, Аssistant of the Department of infectious diseases, epidemiology and childhood infections
Yaroslavl
I. G. Sitnikov
Yaroslavl State Medical University of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Ivan Sitnikov, MD, professor, head of the Department of infectious diseases, epidemiology and childhood infections
Yaroslavl
M. S. Bohonov
Yaroslavl State Medical University of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Maxim Bohonov, PhD, associate professor of the Department of infectious diseases, epidemiology and childhood infections
Yaroslavl
References
1. Novik A.A., Ionova T.I. Research the quality of life in medicine. M.: Geotar-Med., 2004:112—120. (In Russ.)
2. Afanasyeva E.V. Evaluation of the quality of life associated with health. Kachestvennaya Кlinicheskaya Рraktika=Good Сlinical Рractice. 2010;1:36—38. (In Russ.)
3. Gandek B., Ware J. E. SF-36 Health Survey manual and interpretation guide. Boston: the Health institute, New England Medical Center. 1993; 3:1—22.
4. Metko E.E., Polyanskaya A.V. Questionnaire SF-36 as a method of assessing the quality of human life. Electronic scientific journal «Apriori. Series: Natural and Technical Sciences». 2018. (In Russ.)
5. Тuryanov M.Kh., Khromchenko O.M., Komarova T.Yu. The quality of life of patients infected with hepatitis C. Post-graduate Medical Education at the Present Stage. 2000:176—179. (In Russ.)
6. Horváth G., Keleti T., Makara M., Ungvari G.S., Gazdag G. Effect of hepatitis C infection on the quality of life. Perspect. Psychiatr. Care. 2018; 54(3):386—390.
7. Spiegel B.M.R., Younossi Z.M, Hays R.D., Revicki D., Robbins S., Kanwal F. Impact of hepatitis C on health related quality of life: A systematic review and quantitative assessment. J. Hepatology. 2005; 41(4):790—800.
8. Bonkovsky H.L., Snow K.K., Malet P.F., Back-Madruga C., Fontana R. J., Sterling R.K., Kulig C.C., Di Bisceglie A.M., Morgan T.R., Dienstag J. L., Ghany M.G., Gretch D.R. Health-related quality of life in patients with chronic hepatitis C and advanced fibrosis. J. Hepatology. 2007; 46(3):420—431.
9. McHutchison J.G., Ware J.E., Bayliss M.S., Pianko S., Albrecht J.K., Cort S., Yang I., Neary M.P. The effects of interferon alpha-2b in combination with ribavirin on health related quality of life and work productivity. J. Hepatology. 2001; 34(1):140—147.
Review
For citations:
Rozina V.L., Sitnikov I.G., Bohonov M.S. Health-related quality of life in patients with chronic hepatitis C during combined antiviral therapy. CHILDREN INFECTIONS. 2019;18(4):38-42. (In Russ.) https://doi.org/10.22627/2072-8107-2019-18-4-38-42
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