About evaluation of nutritive state in premature infants
https://doi.org/10.22627/2072-8107-2021-20-1-23-27
Abstract
Insulin-like growth factor 1 (IGF-1) plays an important role in the energy balance of the newborn baby's body, is associated with protein stores, which allows us to consider its level as an indicator of nutritional status.
Objective: to study the value of insulin-like growth factor 1 and basic nutrients in the blood in premature infants in the process of neonatal adaptation.
Materials and methods. Dynamics blood levels of insulin-like growth factor 1 in premature newborns included two trends: decrease (1 group) and increase (2 group). During a pregnancy most mothers of newborns from 1 group had been nonspecific respiratory and urinary-sexual organs’sinfectious diseases, in mothers of newborns from 2 group prevailed disorders which carried high risk of fetal hypoxia. During a neonatal period blood levels of albumen of newborns from 1 group decreased and blood levels of glucose increased; blood levels of nutrients in newborns from 2 group did not change.
Conclusions. Dynamics blood levels of insulin-like growth factor 1 in premature newborns are markers of metabolism’s processes which were originated in fetal stage and continue in the neonatal period.
About the Authors
K. V. Dashichev
Yaroslavl State Medical University
Russian Federation
Russian Federation
PhD, Associate Professor
N. V. Olendar
Yaroslavl State Medical University
Russian Federation
Russian Federation
PhD, Associate Professor
T. G. Pukhova
Yaroslavl State Medical University
Russian Federation
Russian Federation
PhD, Associate Professor
E. P. Sitnikova
Yaroslavl State Medical University
Russian Federation
Russian Federation
MD, Professor
References
1. Baranov A.A., Albitsky V.Yu., Volgina S.Ya., Mendelevich V.D. Premature children in childhood and adolescence (medico-psychosocial research). Moscow: Informpress-94; 2001. (In Russ.)
2. Dementieva G.M., Rjumina I.I., Frolova M.I. Nursing of extremely premature infants: Current state of the problem. Pediatriya. 2004; 3:60—6. (In Russ.)
3. Kashyap S., Towers H.M., Sahni R., Ohira-Kist К., Abildskov К.,Schulze K.F. Effect of quality of energy on substrate oxidation enterally fed, low-birth weight infants. Am J Clin Nutr.2001 Sep;74(3):374—80. doi: 10.1093/ajcn/74.3.374.
4. McDermott M. Endocrine Secrets, 4th Edition. 2010. (In Russ.)
5. Larnkjær A., Mølgaard C., Michaelsen Kim F. Early nutrition impact on the insulin-like growth factor axis and later health consequences. Curr Opin Clin Nutr Metab Care.2012 May; 15(3):285—92. doi: 10.1097/MCO.0b013e328351c472.
6. Le Roith D. The insulin-like growth factor system. Exp Diabesity Res. Oct-Dec 2003; 4(4):205-12. doi: 10.1155/EDR.2003.205.
7. Fontana L., Weiss E.P., Villareal D.T., Klein S., Holloszy J.O. Longterm effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans. Aging Cell.2008 Oct; 7(5): 681—687. doi: 10.1111/j.1474-9726.2008.00417.x
8. Hellstrom A., Ley D., Hansen-Pupp I., Hallberg B., Lofqvist C., van Marter L., van Weissenbruch M., Ramenghi L.A., Beardsall K., Dunger D., Hård A., Smith Lois E.H. Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development. Acta Pædiatrica. 2016 Jun; 105(6):576-86. doi: 10.1111/apa.13350
9. Netrebenko O.K. Programming nutrition (metabolic programming) at the early stages of development. Pediatriya. 2013; 92(1):84—92. (In Russ.)
10. Barker D.J.P, Eriksson J.G., Forsén T., Osmond C. Fetal origins of adult disease: strength of effects and biological basis. Int J Epidemiol.2002 Dec; 31(6):1235—9. doi: 10.1093/ije/31.6.1235.
11. Novikova S.V., Tumanova V.A., Logutova L.S., Petrukhin V.A. Compensatory mechanisms of fetal development in placental insufficiency. [edited by] V. I. Krasnopolsky. M.: Medkniga. 2008. (In Russ.)
12. Kocherova V.V., Scherbak V.A. Comatotropny hormone and insulin-like growth factors in the pathogenesis of fetal growth retardation. Pacific Medical Journal. 2016; 63(1):5—8. (In Russ.)
13. Bowman C.J., Streck R.D., Chapin R.E. Maternal-placental insulinlike growth factor (IGF) signaling and its importance to normal embryo-fetal development. Birth Defects Res B Dev Reprod Toxicol. 2010 Aug; 89(4):339—49. doi: 10.1002/bdrb.20249
14. Koutsaki M., Sifakis S., Zaravinos A., Koutroulakis D., Koukoura O., Spandidos D.A. Decreased placental expression of hPGH, IGF-I and IGFBP-1 in pregnancies complicated by fetal growth restriction.Growth Horm IGF Res. 2011 Feb; 21(1):31—6. doi: 10.1016/j.ghir.2010.12.002.
15. Whitehead C.L., Walker S.P., Mendis S., Lappas M., Tong S. Quantifying mRNA coding growth genes in the maternal circulation to detect fetal growth restriction. Am J Obstet Gynecol. 2013 Aug; 209(2):133.e1-9. doi: 10.1016/j.ajog.2013.04.011.
16. Wyrwoll C.S., Mark P.J., Waddell B.J. Developmental programming of renal glucocorticoid sensitivity and the rennin-angiotensin system. Hypertension.2007 Sep; 50(3):579—84. DOI: 10.1161/HYPERTENSIONAHA.107.091603.
17. Ben-Shlomo Y., Holly J., McCarthy A., Savage P., Davies D., Smith G.D. Prenatal and postnatal milk supplementation and adult insulin-like growth factor I: longterm follow-up of a randomized controlled trial. Cancer Epidemiol Biomarkers Prev. 2005;14(5):1336—1339. doi: 10.1158/1055-9965.EPI-04-0908.
18. Netrebenko O.K., Ukraintsev S.E., Melnikova I.Yu. Obesity in Children: New Prevention Concepts and Approaches. Literature Review. Voprosy Sovremennoi Pediatrii=Current Pediatrics. 2017; 16(5): 399—405. doi: 10.15690/vsp.v16i5.1804 (In Russ.)
Review
For citations:
Dashichev K.V., Olendar N.V., Pukhova T.G., Sitnikova E.P. About evaluation of nutritive state in premature infants. CHILDREN INFECTIONS. 2021;20(1):23-27. (In Russ.) https://doi.org/10.22627/2072-8107-2021-20-1-23-27
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