The risks of perinatal HIV/HCV co-infection and the evolution of treatment tactics of the disease in children (clinical case)
https://doi.org/10.22627/2072-8107-2022-21-2-60-66
Abstract
HIV infection and HCV infection are still serious and widespread infections that lead to high morbidity and mortality of the population worldwide.
The aim is to assess the risks of perinatal transmission of HIV/HCV co-infection and the choice of modern treatment tactics in children.
Аnalyzed data in foreign and domestic literature. A clinical case of perinatal transmission of HIV/HCV co-infection is described.
Results. Тhe features of perinatal transmission of infection depending on its variants (mono-HIV infection, hepatitis C and co-infection with HIV/HCV) and risk factors are shown. A clinical example demonstrates the implementation of perinatal transmission of HIV/HCV co-infection in the presence of major risk factors. The improvement of therapeutic tactics in a child with co-infection is shown.
Conclusion: in the described clinical case, numerous risk factors for perinatal transmission of HIV/HCV co-infection are demonstrated, the presence of which led to the realization of co-infection in a child. The effectiveness of modern tactics for the treatment of HIV infection and chronic viral hepatitis C has been demonstrated.
About the Authors
A. A. Khamatova
Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation; Moscow City Center for the Prevention and Control of AIDS, Infectious Clinical Hospital No. 2 of the Moscow Department of Health
Russian Federation
Russian Federation
Moscow
T. A. Chebotareva
Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
MD
Moscow
J. F. Vlatskaya
Moscow City Center for the Prevention and Control of AIDS, Infectious Clinical Hospital No. 2 of the Moscow Department of Health
Russian Federation
Russian Federation
PhD
Moscow
References
1. http://apps.who.int/iris/bitstream/handle/10665/342808/9789240030985-eng.pdf
2. Sadovnikova V.N. Prevention of vertical transmission of HIV infection from mother to child in the Russian Federation. The current state of the problem and ways to solve it. Voprosi Рracticheskoi Рediatrii=Questions of Practical Pediatrics. 2008; 3(2):53—58. (In Russ.)
3. AbdulQawi K., Youssef A., Metwally M.A., Ragih I., AbdulHamid M., Shaheen A. Prospective study of prevalence and risk factors for hepatitis C in pregnant Egyptian women and its transmission to their infants. Croat Med J. 2010; 51(3):219—228. doi: 10.3325/cmj.2010.51.219.
4. Ezechi O.C., Kalejaiye O.O., Gab-Okafor C.V., Oladele D.A., Oke B.O., Musa Z. A., Ekama S.O., Ohwodo H., Agahowa E., Gbajabiamilla T., Ezeobi P.M., Okwuraiwe A., Audu R R.A., Okoye R. N., David A. N., Odunukwe N. N., Onwujekwe D. I., Ujah I.A.. Sero-prevalence and factors associated with Hepatitis B and C co-infection in pregnant Nigerian women living with HIV Infection. Pan Afr Med J. 2014; 17:197. doi: 10.11604/pamj.2014.17.197.2310.
5. Roudot-Thoraval F., Pawlotsky J.M., Deforges L. Girollet P.P., Dhumeaux D. Anti-HCV seroprevalence in pregnant women in France. Gut. 1993; 34(2 Suppl):S55—56. doi: 10.1136/gut.34.2_suppl.s55.
6. Shakhanina I.L., Raduto O.I. Viral hepatitis in Russia in 2000: prevalence and economic losses. «Materials of the VIII Congress of the All-Russian Society of Epidemiologists, Microbiologists, and Parasitologists». Moscow. 2002. 3:85—86. (In Russ.)
7. Mateiko G.B. Matvisiv M.V. Realization of intrauterine infection in a mother with HIV/HCV co-infection. Klinicheskaya Infektologiya i Parazitologiya = Clinical Infectology and Parasitology. 2016; 5(1): 96—104. (In Russ.) ISSN: 2306-8787
8. Floreani A. Hepatits C and pregnancy. World Journal of Gastroenterology. 2013; 19(40):6714—6720. https://www.wjgnet.com/1007-9327/full/v19/i40/6714.htm
9. Huong N., Jourdain G., Siriungsi W., Decker L., Khamduang W., Le Coeur S., Sirinontakan S., Somsamai R., Pagdi K., Hemvuttiphan J., Mclntosh K., Barin F., Lallemant M. Human immunodeficiency virushepatitis C virus co-infection in pregnant women and perinatal transmission to infants in Thailand. Int J Infect Dis. 2010; 14(7): 602—607. doi: 10.1016/j.ijid.2009.09.002
10. Balmasova I.P., Aristanbekova M.S., Malova E.S., Sepiashvili R.I. Mechanisms of interaction of viral causative agents in patients coinfected with human immunodeficiency and hepatitis C viruses. Jurnal Мicrobiologii=Journal of Мicrobiology. 2016; 5:101—109. (In Russ.)
11. Connell L.E., Salihu H.M., Salemi J.L., August E.M. Weldeselasse H., Mbah A.K. Maternal hepatitis B and hepatitis C carrier status and perinatal outcomes. Liver Int. 2011; 31(8):1163—1170. doi: 10.1111/j.1478-3231.2011.02556.x
12. Reddick KLB, Jhaveri R., Gandhi M. James A.H., Swamy G.K. Pregnancy outcomes associated with viral hepatitis. J Viral Hepat. 2011; 1:e394—398. doi: 10.1111/j.1365-2893.2011.01436.x
13. Huang Q-T., Huang Q., Zhong M. Wei S-S., Luo W., Li F., Yu Y-H. Chronic hepatitis C virus infection is associated with increased risk of preterm birth: a meta-analysis of observational studies. J Viral Hepat. 2015; 22(12):1033—1042. doi: 10.1111/jvh.12430
14. Benhammou V., Tubiana R., Matheron S., Sellier P., Mandelbrot L., Chenadec J. L., Marel E., Khoshnood B., Warszawski J. HBV or HCV Coinfection in HIV-1-infected Pregnant Women in France: Prevalence and Pregnancy Outcomes. JAIDS. 2018; 77(5):439—450. doi: 10.1097/QAI.0000000000001618
15. Mitsoda R.M. Prediction of obstetric complications in women with chronic hepatitis C and human immunodeficiency virus. Scientific Bulletin Uzhgorod University, Series «Medicine». 2011; 40: 261—263. https://dspace.uzhnu.edu.ua/jspui/handle/lib/6445
16. Cowie B., Dore G., Sasadeusz J. Co-infection: HIV&Viral Hepatitis. A Guide for Clinical Management 4 th edition. ASHM. 2010: 6—9.
Review
For citations:
Khamatova A.A., Chebotareva T.A., Vlatskaya J.F. The risks of perinatal HIV/HCV co-infection and the evolution of treatment tactics of the disease in children (clinical case). CHILDREN INFECTIONS. 2022;21(2):60-66. (In Russ.) https://doi.org/10.22627/2072-8107-2022-21-2-60-66
Views:
518
Email this article 