Correlations of interleukin levels with the severity of SARS-CoV-2 coronavirus infection
https://doi.org/10.22627/2072-8107-2023-22-1-11-13
Abstract
A new coronavirus infection caused by the SARS-CoV-2 virus is characterized by a systemic hyperinflammatory response with a pronounced increase in the content of pro-inflammatory cytokines. Materials and methods. The study was conducted on the basis of the Samara Regional Children's Infectious Diseases Hospital from 2021 to 2022. 40 patients with moderate (n = 20, group I) and severe forms (n = 20, group II) COVID-19 were studied, the comparison group consisted of patients with viral pneumonia of another etiology (n = 35, group III). Results. The infectious agent SARS-CoV-2 induces high levels of cytokines IL-6 (p < 0.005), IL-8 (p < 0.05) and a slight increase in TNF-α (p < 0.05). IL-8 was significantly associated with disease duration (p < 0.01). We assume that the value of this interleukin will increase in the post-COVID period. Conclusions. Changes in IL-6 and IL-8 levels in patients with COVID-19, along with clinical features, are important biomarkers for predicting the severity and duration of the disease.
About the Authors
O. N. Yashkina
Samara State Medical University of the Ministry of Health of Russia
Russian Federation
Russian Federation
Yashkina O.
Samara
N. G. Tsareva
Samara State Medical University of the Ministry of Health of Russia
Russian Federation
Russian Federation
Tsareva N.
Samara
O. V. Borisova
Samara State Medical University of the Ministry of Health of Russia
Russian Federation
Russian Federation
Borisova О.
Samara
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Review
For citations:
Yashkina O.N., Tsareva N.G., Borisova O.V. Correlations of interleukin levels with the severity of SARS-CoV-2 coronavirus infection. CHILDREN INFECTIONS. 2023;22(1):11-13. (In Russ.) https://doi.org/10.22627/2072-8107-2023-22-1-11-13
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