Possibilities of prediction of сampylobacteriosis adverse outcomes in children

Abstract

In addition to the problem of high morbidity in the child population, there is a high risk of developing post-infectious functional gastrointestinal disorders (PFGID). The aim of the study was to establish the frequency and structure of functional gastrointestinal disorders in campylobacteriosis convalescents. Patients and methods. The study included 200 children who were treated in a specialized department of the DNNCIB FMBA of Russia in the period 2018—2021. associated with campylobacteriosis. Clinical observation of patients was carried out in a hospital, followed by follow-up observation for 12 months. Results. 180 (90%) patients passed the full observation period. At the time of the start of the follow-up observation only 26 (13%) children had complaints about health conditions: abdominal pain when eating (n = 15; 7.5%), flatulence (n = 19; 9 .5%), mushy stools, loss of appetite (n = 5; 2.5%), constipation (n = 10; 5.0%). Most often, the appearance of complaints from the digestive organs appeared in the period from 90 to 180 days. Among the symptoms detected in children after campylobacteriosis, the most common were the appearance of periodic pain, abdominal discomfort (n = 64, 32%) and constipation (n = 53; 26.5%). The older group was diagnosed with: irritable bowel syndrome (n = 19; 51.4%), functional dyspepsia (n = 14; 37.8%) and functional constipation (n = 4; 10.8%). In the younger age group, the following were diagnosed: functional constipation (n = 18; 60.0%) and functional diarrhea (n = 12; 40.0%). Conclusions. The dynamic dispensary observation of campylobacteriosis convalescents made it possible to diagnose PFGIR in 67 (33.5%) children. On the basis of the study, a mathematical and statistical model for predicting PFGIR was developed, which allows, based on the assessment of clinical and anamnestic signs, to identify children at risk. The predictors of PFGIR in children who have had campylobacteriosis included in the prognosis model include: admission to the hospital at a late stage of the disease with severe severity of campylobacteriosis on the Clark scale, the appointment of several courses of antibacterial drugs, forced transfer to artificial feeding, age, the presence of hemocolitis, the severity of dehydration.