CLINICAL AND MICROBIOLOGICAL EFFICACY OF ANTIBIOTIC THERAPY OF ACUTE INTESTINAL INFECTIONS WITH INVASIVE TYPE OF DIARRHEA IN CHILDREN
https://doi.org/10.22627/2072-8107-2015-14-1-27-30
Abstract
In the article results of a randomized comparative multicenter study of the clinical and microbiological efficacy and safety of azithromycin (Sumamed) and cefixime (Suprax) 185 children aged 1—14 years with moderate (70.8%) and severe forms (29.2%) of acute intestinal infections with invasive type of diarrhea. Etiological diagnosis microbiological method was detected in 48 (25.9%) patients, including salmonellosis in 85.4% of cases sonnei shigellosis or Flexner in 14.6% of patients. Found that both drugs have a high clinical efficacy (of 86.2% and 87.2%, respectively). While, microbiological efficacy of azithromycin was significantly higher (83.3%) than of cefixime (58.3%) (p < 0.001), including, when salmonellosis she reached 81.8% and that of cefixime, only 52.6% of patients. A clinical study confirmed the safe use of these antimicrobial agents in the treatment of acute intestinal infections in children.
About the Authors
N. N. Smolyankin
Smolensk state medical University of Ministry of health of the Russian Federation
Russian Federation
assistant Department of infectious diseases in children at the Smolensk state medical University of Ministry of health of the Russian Federation; 21400, Smolensk, Frunze St. 40, City clinical hospital №1, Department of infectious diseases in children; (4812) 27-09-92
Russian Federation
assistant Department of infectious diseases in children at the Smolensk state medical University of Ministry of health of the Russian Federation; 21400, Smolensk, Frunze St. 40, City clinical hospital №1, Department of infectious diseases in children; (4812) 27-09-92
A. I. Grekova
Smolensk state medical University of Ministry of health of the Russian Federation
Russian Federation
Russian Federation
L. P. Zharkova
Smolensk state medical University of Ministry of health of the Russian Federation
Russian Federation
Russian Federation
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Review
For citations:
Smolyankin N.N., Grekova A.I., Zharkova L.P. CLINICAL AND MICROBIOLOGICAL EFFICACY OF ANTIBIOTIC THERAPY OF ACUTE INTESTINAL INFECTIONS WITH INVASIVE TYPE OF DIARRHEA IN CHILDREN. CHILDREN INFECTIONS. 2015;14(1):27-30. (In Russ.) https://doi.org/10.22627/2072-8107-2015-14-1-27-30
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