BIOLOGYCAL IMUNOMODULATORS IN THE COMPLEX THERAPY OF INFECTIOUS MONONUCLEOSIS IN CHILDREN
https://doi.org/10.22627/2072-8107-2015-14-1-3-8
Abstract
80 patients were observed with infectious mononucleosis (IM) from 2 to 12 years. Diagnosis was confirmed by the definition of M- and G-antibodies to EBV, CMV, HHV6, PCR DNA these viruses, bacteriological and blood-tests investigations. 40 patients was given bifidumbacterin forte 45—90 doses a day and cycloferon 8 mg/kg/weight a day(1-st group). The comparison group consisted of 40 patients with IM receiving symptomatic therapy and antibiotics (2-nd group). The observations shoved significant decreasing of length of clinical symptoms IM in the 1-st group with comparison of the 2-nd group. The obtained results allow to recommend bifidumbacterin forte and cycloferon in the complex therapy in children with infectious mononucleosis.
About the Authors
A. G. Bokovoy
Сentral Clinical Hospital of Government Russian Federation, Moskow
Russian Federation
DMS, Professor, Сentral clinical hospital of Government Russian Federation, Moskow; (495) 414-03-44
Russian Federation
DMS, Professor, Сentral clinical hospital of Government Russian Federation, Moskow; (495) 414-03-44
I. V. Kovalev
Сentral Clinical Hospital of Government Russian Federation, Moskow
Russian Federation
Russian Federation
L. F. Makkaveeva
Сentral Clinical Hospital of Government Russian Federation, Moskow
Russian Federation
Russian Federation
O. A. Volodina
Сentral Clinical Hospital of Government Russian Federation, Moskow
Russian Federation
Russian Federation
A. A. Komarov
Сentral Clinical Hospital of Government Russian Federation, Moskow
Russian Federation
Russian Federation
A. Yu. Medkova
Сentral Clinical Hospital of Government Russian Federation, Moskow
Russian Federation
Russian Federation
N. B. Tanina
Сentral Clinical Hospital of Government Russian Federation, Moskow
Russian Federation
Russian Federation
References
1. Granitov V.M. Gerpesvirusnaya infektsiya [Herpes infektsiya]. — N.Novgorod: NGMA, 2001 — 80 s. (In Russ).
2. Goryacheva L.G. Primenenie tsikloferona v pediatrii [Primenenie tsikloferona in pediatrics] / L.G. Goryacheva,V.V. Botvineva, M.G. Romantsov. — 2104. — M. — S.Peterburg. — 58 str. (In Russ).
3. Krasnov V.V. Infektsionnyiy mononukleoz. Klinika, diagnostika, sovremennyie printsipyi lecheniya [Infectious mononucleosis. Clinic, diagnostics, Modern principles of treatment]. — S.Peterburg — N.Novgorod, 2003. — 43 s. (In Russ).
4. Ershov F.I. Sovremennyiy arsenal antigerpeticheskih lekarstvennyih Sredstv [Modern arsenal antiherpetic drugs funds] / F.I .Ershov, T.P. Ospelnikova // Infektsii i Antimikrobnaya Terapiya. — 2001. — t. 3, № 4. — S. 100 — 104. (In Russ).
5. Hickey S.M., Strasburger V.C. What every pediatrician should know infectious mononucleosis in adolescents // Pediatr.Clin.North.Am. — 1997. — V. 44, № 6. — P. 1541—1556.
6. Red Book. American Academy of Pediatrics/ J.S. Abramson et al.— 2000. — P. 240—244.
7. Detskie infektsionnyie bolezni [Childrens infectious diseases] / V.V. Fomin i dr. — Ekaterinburg, 2000.— ch.1, S.661—686. (In Russ).
8. Uchaykin V.F. Rukovodstvo po infektsionnyim boleznyam u detey [Guidelines for Infectious Diseases in children]. — M.:GEOTAR Meditsina, 1998. — 809 s. (In Russ).
9. Ko-infektsiya pri ORVI-pnevmoniyah u detey i obosnovanie primeneniya vyisokih doz bifidumbakterina-forte dlya immunobiologicheskoy korrektsii [Ko infection with SARS-pneumonia in children and rationale for the use high doses bifidumbacterin forte for immunobiological correction] / Lyikova E.A. i dr. // Tezisyi V Rossiyskoy konferentsii «Sovremennyie problemyi antimikrobnoy himioterapii», M., 2—3 oktyabrya, 2000 [Abstracts V Russian Conference «Modern Problems of Antimicrobial Chemotherapy», M., 2— 3 October]. — S. 12—16. (In Russ).
10. Lechenie ostryih kishechnyih infektsiy u detey preparatami bifidumbakterin-forte i probifor [Treatment acute intestinal infections in children drugs bifidumbacterin-forte and Probifor ] / Novokshonov A.A.i dr. — Moskva, 2001. — 16 s. (In Russ).
11. Ispolzovanie bolshih doz probiotika bifidumbakterina forte v lechenii ORVI u detey: klinicheskie i immunobiologicheskie rezultatyi [Use large doses of probiotic bifidumbacterin forte treatment of ARI in children: clinical and immunobiological results] / Vorobev A.A. i dr. // Epidemiologiya i Infektsionnyie Bolezni. — 2004.— № 5.— S. 43— 46. (In Russ).
Review
For citations:
Bokovoy A.G., Kovalev I.V., Makkaveeva L.F., Volodina O.A., Komarov A.A., Medkova A.Yu., Tanina N.B. BIOLOGYCAL IMUNOMODULATORS IN THE COMPLEX THERAPY OF INFECTIOUS MONONUCLEOSIS IN CHILDREN. CHILDREN INFECTIONS. 2015;14(1):30-35. (In Russ.) https://doi.org/10.22627/2072-8107-2015-14-1-3-8
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