The probiotics influence on the acute osmo-secretory diarrhea in children
https://doi.org/10.22627/2072-8107-2023-22-1-32-36
Abstract
Nowadays acute gastroenteritis retains the leading infectious disorder in children, has viral etiology and osmosecretory type of diarrhea in the most cases. Probiotics are considered highly effective medicines as part of the complex gastroenteritis therapy in children. The choice of the probiotics is limited by strains with proven efficacy and complicated by a large range of commercially available probiotics. The aim of the comparative post-registration prospective study was to evaluate the efficacy and safety the probiotic drug Adiarin Probio for treatment of osmosecretory diarrhea inpatient children. The study included 60 hospitalized children aged 6 months to 7 years. Results: the efficacy and safety as well as high adherence to the Adiarin Probio in children with osmosecretory diarrhea were confirmed.
About the Authors
E. Dondurey
Scientific Research Institute of Influenza named after A.A. Smorodintsev of the Ministry of Health of the Russian Federation; Children's City Clinical Hospital No. 5 named after N.F. Filatov
Russian Federation
Russian Federation
Dondurey Е., PhD
Saint-Petersburg
I. Kosenko
Children's City Clinical Hospital No. 5 named after N.F. Filatov; St. Petersburg State Pediatric Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Kosenko I., PhD
Saint-Petersburg
E. Kostitsyna
Children's City Clinical Hospital No. 5 named after N.F. Filatov
Russian Federation
Russian Federation
Kostitsyna E.
Saint-Petersburg
Y. Polkovnikova
Children's City Clinical Hospital No. 5 named after N.F. Filatov
Russian Federation
Russian Federation
Polkovnikova Y.
Saint-Petersburg
A. Shestakova
Children's City Clinical Hospital No. 5 named after N.F. Filatov
Russian Federation
Russian Federation
Shestakova А.
Saint-Petersburg
References
1. On the state of sanitary and epidemiological well-being of the population in the Russian Federation in 2019: State report. Moscow: Federal Service for Supervision of Consumer Rights Protection and Human Welfare, 2020:299. (In Russ.)
2. On the state of sanitary and epidemiological well-being of the population in the Russian Federation in 2020: State report. Moscow: Federal Service for Supervision of Consumer Rights Protection and Human Welfare, 2021:256. (In Russ.)
3. Lobzin Yu.V., Rychkova S.V., Uskov A.N., Skripchenko N.V., Fedorov V.V. Modern trends of infectious morbidity in children in the Russian Federation. Kubanskiy Nauchnyy Meditsinskiy Vestnik = Kuban Scientific Medical Bulletin. 2020; 4(27): 119—133. (In Russ.) https://doi.org/10.25207/1608-6228-2020-27-4-119-133.
4. Ploskireva A.A., Gorelov A.V. Algorithm of therapy of acute intestinal infections in children. Lechashhij Vrach. 2016; 3:55. (In Russ.)
5. WHO global health estimates (https://www.who.int/data/global-health-estimates).
6. Novokshonov A.A., Mazankova L.N., Uchajkin V.F. Clinical recommendations for the diagnosis and treatment of acute intestinal infections in children, depending on the type of diarrhea. Lechenie i Рrofilaktika. 2013; 4(8):62—73. (In Russ.)
7. Ploskireva A.A. Probiotic therapy for acute intestinal infections in children. Lechashhij Vrach. 2018; 6:20—24. (In Russ.)
8. Sekirov I., Finlay B.B. The role of the intestinal microbiota in enteric infection. Shenderov B. A. Medical microbial ecology and functional nutrition. Vol.3: Probiotics and functional nutrition. M.: Grant, 2001:286.
9. Clinical recommendations (treatment protocol) of medical care for children with rotavirus infection. St. Petersburg, 2015:88. (In Russ.)
10. Allen S.J., Martinez E.G., Gregorio G.V. et al. Probiotics for treating acute infectious diarrhea. Cochrane Database Syst Rev. 2010; CD003048.
11. Quigley E.M. Gut microbiota and the role of probiotics in therapy. Curr Opin Pharmacol. 2011; 11(6):593—603.
12. Hojsak I., Fabiano V., Pop T.L., Goulet O. et al. Guidance on the use of probiotics in clinical practice in children with selected clinical conditions and in specific vulnerable groups. Acta Paediatr. 2018; Jun 107(6):927—937. DOI:10.1111/apa.14270.
13. ICH guideline E2C (R2) on periodic benefit-risk evaluation report (PBRER). January 2013 EMA/CHMP/ICH/544553/1998.
Review
For citations:
Dondurey E., Kosenko I., Kostitsyna E., Polkovnikova Y., Shestakova A. The probiotics influence on the acute osmo-secretory diarrhea in children. CHILDREN INFECTIONS. 2023;22(1):32-36. (In Russ.) https://doi.org/10.22627/2072-8107-2023-22-1-32-36
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