A case of early neonatal sepsis caused by Streptococcus pneumoniae
S. V. Dumova,
I. O. Kuzmina,
O. L. Chugunova,
S. I. Zhogin,
D. V. Lychagina,
O. G. Ni,
V. V. Voronov,
A. A. Khanmagomedova,
L. D. Vorona,
E. A. Sarkisyan,
P. V. Shumilov https://doi.org/10.22627/2072-8107-2024-23-2-39-44
Abstract
The article presents a case of early neonatal sepsis in a premature neonate caused by Streptococcus pneumoniae with the development of purulent meningitis, describes the diagnostic possibilities and features of treatment, as well as the outcome of this condition in the child. In the presented case the rapid increase of symptoms of meningo-encephalitis, slow sanation of liquor, despite the adequacy of the conducted therapy, attracts attention.
About the Authors
S. V. Dumova
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
I. O. Kuzmina
Moscow Multidisciplinary Clinical Center ‘Kommunarka’
Russian Federation
Russian Federation
Moscow
O. L. Chugunova
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
S. I. Zhogin
Moscow Multidisciplinary Clinical Center ‘Kommunarka’
Russian Federation
Russian Federation
Moscow
D. V. Lychagina
Moscow Multidisciplinary Clinical Center ‘Kommunarka’
Russian Federation
Russian Federation
Moscow
O. G. Ni
Moscow Multidisciplinary Clinical Center ‘Kommunarka’
Russian Federation
Russian Federation
Moscow
V. V. Voronov
Moscow Multidisciplinary Clinical Center ‘Kommunarka’
Russian Federation
Russian Federation
Moscow
A. A. Khanmagomedova
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
L. D. Vorona
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
E. A. Sarkisyan
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
P. V. Shumilov
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
References
1. Oza S., Lawn J.E., Hogan D.R., Mathers C., Cousens S.N. Neonatal cause-of-death estimates for the early and late neonatal periods for 194 countries: 2000—2013. Bull World Health Organ. 2015 Jan 1;93(1):19—28. doi: 10.2471/BLT.14.139790.
2. Ivanova O. N., Grigoriev E. V. Diagnostic markers of early neonatal sepsis — limitations and prospects. Vestnik Anesthesiologii i Reanimatologii. 2020. 17(6):72—79. DOI: 10.21292/2078-5658-2020-17-6-72-79 (In Russ).
3. Singh M., Alsaleem M., Gray C.P. Neonatal Sepsis. 2022 Sep 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan.
4. Köstlin-Gille N., Härtel C., Haug C., Göpel W., Zemlin M., Müller A., Poets C.F., Herting E., Gille C.. Epidemiology of Early and Late Onset Neonatal Sepsis in Very Low Birthweight Infants: Data From the German Neonatal Network. Pediatr Infect Dis J. 2021 Mar 1; 40(3):255—259. doi: 10.1097/INF.0000000000002976
5. Klingenberg K., R.F. Cornelisse, D. Buonocore [et al.] Early neonatal sepsis with negative cultures: at the crossroads between effective sepsis treatment and antimicrobial therapy strategy. Neonatologiya: Novosti, Mneniya, Оbucheniye=Neonatology: News, Opinions, Training. 2020. 8(1(27): 95— 106. (In Russ).
6. Gusev E.Y., Zotova N.V., Chereshnev V.A. Sepsis-3: new edition — old problems. Analysis from the position of general pathology. Infection and Immunity. 2021. 11(4):649—662. (In Russ). doi: 10.15789/2220-7619-SAN-1629
7. Lekmanov A.U., Mironov P.I., Alexandrovich Y.S., Azovsky D.K., Popov D.A., Pshenisnov K.V., Muzurov A.L., Degtyareva E.A. Sepsis in children: federal clinical recommendations (draft). Russian Journal of Pediatric Surgery, Anesthesiology and Resuscitation. 2021. 11(2):241—292. (In Russ). DOI: https://doi.org/10.17816/psaic969р
8. Kirilochev O. K., Eiberman A. S., Bochkova L. G. Possibilities of using the pSOFA assessment scale for the diagnosis of sepsis in newborns. Lechaschichnyi Vrach. 2022; 1(25):8—13. (In Russ). DOI: 10.51793/OS.2022.25.1.001
9. Idrisova R.G., Amirova V.R., Mironov P.I., Lekmanov A.U. Comparative evaluation of the prognostic ability of nSOFA and NEOMOD scales in premature newborns. Russian Journal of Pediatric Surgery, Anesthesiology and Resuscitation. 2022. 12(3):351—359. (In Russ). DOI: https://doi.org/10.17816/psaic1278
10. Sepsis: classification, clinical and diagnostic concept and treatment . Edited by Academician of the RAS B.R. Gelfand. 4th edition, add. and revised. Moscow: LLC «Medical News Agency», 2017:408. (In Russ).
11. Qiu X., J. Li, X. Yang et al. Is neutrophil CD11b a special marker for the early diagnosis of sepsis in neonates? A systematic review and meta-analysis. BMJ Open. 2019. 9(4):e025222
12. Boscarino G, Migliorino R, Carbone G, Davino G, Dell'Orto VG, Perrone S, Principi N, Esposito S. Biomarkers of Neonatal Sepsis: Where We Are and Where We Are Going. Antibiotics (Basel). 2023 Jul 26; 12(8):1233. doi: 10.3390/antibiotics12081233.
13. Morris R., Jones S., Banerjee S., Collinson A., Hagan H., Walsh H., Thornton G., Barnard I., Warren C., Reid J., et al. Comparison of the management recommendations of the Kaiser Permanente neonatal early-onset sepsis risk calculator (SRC) with NICE guideline CG149 in infants ≥34 weeks’ gestation who developed early-onset sepsis. Arch. Dis. Child. Fetal Neonatal Ed. 2020; 105:581—586. doi: 10.1136/archdischild-2019-317165
14. Hershkovich-Shporen C., Guri A., Gluskina T., Flidel-Rimon O. Centers for disease control and prevention guidelines identified more neonates at risk of early-onset sepsis than the Kaiser-Permanente calculator. Acta Paediatr. 2022; 111:767—771. doi: 10.1111/apa.16232
15. Khayertynov Kh.S., Anokhin V.A., Mustafin I.G., Boichuk S.V., Khasanova G.R., Lyubin S.A. Immunosuppression in neonatal sepsis. Practical Мedicine. 2019. 17(5):165—169. (In Russ). DOI: 10.32000/2072-1757-2019-5-165-169
16. Ippolitova L.I., Korotaeva N.V., Pershina E.S. Markers of early inflammation in the diagnosis of neonatal sepsis. Medical Scientific Bulletin of Central Chernozemye. 2023. 91:66—72. (In Russ).
17. Brown J, Meader N, Cleminson J, McGuire W. C-reactive protein for diagnosing late-onset infection in newborn infants. Cochrane Database of Systematic Reviews 2019, Issue 1. Art. No.: CD012126. DOI: 10.1002/14651858.CD012126.pub2
18. Obedin A.N., Vasilyev A.Yu., Volkov Ye.V. Diagnostic information value of presepsin and traditional markers in the blood serum of premature newborns with early neonatal sepsis. Russian Вiomedical Research. 2022. 7(4):68— 73. (In Russ). DOI 10.56871/RBR.2022.92.20.010
19. O'Sullivan C, Tsai DH, Wu IC, Boselli E, Hughes C, Padmanabhan D, Hsia Y. Machine learning applications on neonatal sepsis treatment: a scoping review. BMC Infect Dis. 2023 Jun 29; 23(1):441. doi: 10.1186/s12879-023-08409-3
20. Jarovsky D, Marchetti IC, da Silva Mori MA, de Souza RM, Almeida FJ, Sáfadi MAP, Berezin EN. Early-onset Neonatal Pneumococcal Sepsis: A Fatal Case Report and Brief Literature Review. Pediatr Infect Dis J. 2018 Apr; 37(4):e111-e112. doi: 10.1097/INF.0000000000001818
21. Agarkova A.A., M.V. Pokrovsky, L.V. Korokina, O.A. Zemlyansky. Pneumococcal meningitis: modern aspects of diagnosis and treatment. Klinicheskaya Farmakologiya i Terapiya=Clinical Рharmacology and Тherapy. 2019; 28(2):84—92. (In Russ)
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For citations:
Dumova S.V., Kuzmina I.O., Chugunova O.L., Zhogin S.I., Lychagina D.V., Ni O.G., Voronov V.V., Khanmagomedova A.A., Vorona L.D., Sarkisyan E.A., Shumilov P.V. A case of early neonatal sepsis caused by Streptococcus pneumoniae. CHILDREN INFECTIONS. 2024;23(2):39-44. (In Russ.) https://doi.org/10.22627/2072-8107-2024-23-2-39-44
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