A case of infectious mononucleosis caused by Epstein-Barr virus complicated by autoimmune hemolytic anemia
https://doi.org/10.22627/2072-8107-2024-23-2-55-60
Abstract
We represent a rare clinical case of infectious mononucleosis with hepatitis, caused by Epstein-Barr virus, complicated by rare secondary autoimmune hemolytic anemia associated with warm agglutinins in a 16-year-old patient. The disease was long-lasting, with a two-wave course of febrile fever. Signs of hepatitis with the development of anemia of moderate severity appeared during the second wave of febrile fever. The etiology of the disease was confirmed by the detection of Epstein-Barr virus DNA in blood and the detection of anti-VCA IgM antibodies to Epstein-Barr virus in the absence of anti-EBNA IgG antibodies. Hemolytic anemia was verified using markers of hemolysis (increased lactate dehydrogenase activity, decreased haptoglobin concentration), and positive results of a direct Coombs test. After successful initiation of prednisone therapy and clinical improvement, the patient was discharged from the hospital on the 24th day of disease to continue treatment on an outpatient basis (prednisone was replaced by methylprednisolone).
This case demonstrates the development of a rare autoimmune complication in infectious mononucleosis caused by the Epstein-Barr virus.
About the Authors
R. F. Sayfullin
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
K. E. Abdieva
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
A. V. Razumeykina
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
A. P. Zolotareva
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
O. A. Ivanova
Infectious Clinical Hospital No. 1
Russian Federation
Russian Federation
Moscow
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Review
For citations:
Sayfullin R.F., Abdieva K.E., Razumeykina A.V., Zolotareva A.P., Ivanova O.A. A case of infectious mononucleosis caused by Epstein-Barr virus complicated by autoimmune hemolytic anemia. CHILDREN INFECTIONS. 2024;23(2):55-60. (In Russ.) https://doi.org/10.22627/2072-8107-2024-23-2-55-60
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