SUSCEPTIBILITY OF BORDETELLA PERTUSSIS STRAINS TO ANTIBACTERIAL PREPARATIONS
https://doi.org/10.22627/2072-8107-2013-12-2-46-50
Abstract
178 strains of B. pertussis isolated from infected individuals in various regions of Russia from 1948 to 2012 have been studied for their susceptibility to six antibacterial preparations. It has been shown, that B. pertussis strains isolated from 1948 to 1989 were predominantly sensitive to erythromycin. In the following years a gradual decrease in susceptibility of circulating strains of B. pertussis to this antibiotic was registered with the emergence of strains with intermediate susceptibility in 22% of cases from 1990 to 2005 (MIC 0,060 mcg/mL), up to 59,3% in the last six years (MIC 0,125 mcg/mL). As for azithromycin, high susceptibility of strains of B. pertussis to this preparation was shown throughout the entire duration of the survey. However, the rate of incidence of intermediate strains reached 14% among those strains isolated from 1990 to 2005, and is now at 32%. Thus, after several decades of active use of antibiotics pertussis underwent a series of transformations resulting in a decrease in susceptibility of B. pertussis strains to erythromycin and azithromycin.
About the Authors
O. Yu. Borisova
Moscow Research Institute of Epidemiology and Microbiology named after G.N. Gabrichevsky, Moscow
Russian Federation
Russian Federation
A. V. Aleshkin
Moscow Research Institute of Epidemiology and Microbiology named after G.N. Gabrichevsky, Moscow
Russian Federation
Russian Federation
G. A. Ivashinnikova
Moscow Research Institute of Epidemiology and Microbiology named after G.N. Gabrichevsky, Moscow
Russian Federation
Russian Federation
E. E. Donskikh
Russian National Research Medical University named after N.I. Pirogov, Moscow
Russian Federation
Russian Federation
E. A. Postnikova
Russian National Research Medical University named after N.I. Pirogov, Moscow
Russian Federation
Russian Federation
V. A. Alyeshkin
Moscow Research Institute of Epidemiology and Microbiology named after G.N. Gabrichevsky, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Borisova O.Yu., Aleshkin A.V., Ivashinnikova G.A., Donskikh E.E., Postnikova E.A., Alyeshkin V.A. SUSCEPTIBILITY OF BORDETELLA PERTUSSIS STRAINS TO ANTIBACTERIAL PREPARATIONS. CHILDREN INFECTIONS. 2013;12(2):46-50. (In Russ.) https://doi.org/10.22627/2072-8107-2013-12-2-46-50
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