Clinical cases of hemolytic-uremic syndrome in children with E. coli infection
https://doi.org/10.22627/2072-8107-2025-24-2-34-38
Abstract
Among other children infectious diseases hemolytic-uremic syndrome (HUS) remains a significant issue since it can lead to death or chronic kidney pathology. The most vulnerable group are children under the age of 5. The progression of HUS triggered by bacterial intestinal infections is more likely to occur as a sporadic disease in the summer-autumn period.
Materials and methods. The article describes clinical observations of patients undergoing treatment at the children infectious hospital at the Budgetary Healthcare Institution of Omsk Oblast City Clinical Hospital №1 named after A.N. Kabanov in Omsk. In each case the development of HUS was preceded by symptoms of acute intestinal infections of medium severity. Сlinical and laboratory manifestations matched the classic version of HUS development. When conducting bacteriological research of stool, causative agents of intestinal infections were not identified. Only in two cases etiological agent was identified using PCR.
About the Authors
Yu. B. Belan
Omsk State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Omsk
E. A. Gashina
Омский государственный медицинский университет, Минздрава России
Russian Federation
Russian Federation
Omsk
E. F. Lobova
Омский государственный медицинский университет
Минздрава России
Russian Federation
Russian Federation
Omsk
L. V. Puzyreva
Омский государственный медицинский университет Минздрава России
Russian Federation
Russian Federation
Omsk
I. S. Merson
Budgetary Healthcare Institution of Omsk Oblast City Clinical Hospital №1 named after A.N. Kabanov in Omsk, Сhildren infectious hospital
Russian Federation
Russian Federation
Omsk
References
1. Gonchar N.V., Ermolenko K.D., Klimova O.I., Martens E.A, LobzinIu.V., Mardanly S.G. Escherichiosis in children: problems of diagnosis and treatment. Klinicheskaya Мedicina. 2020; 22(2):148—158. (In Russ.)
2. Garg AX, Suri RS, Barrowman N, Rehman F, Matsell D, Rosas-Arellano MP, Salvadori M, Haynes RB, Clark WF. Long-term renal prognosis of diarrheaassociated hemolytic uremic syndrome: a systematic review, meta-analysis, and meta-regression. JAMA. 2003 Sep 10; 290(10):1360—70. doi: 10.1001/jama.290.10.1360. PMID: 12966129.
3. Сenter for disease control and prevention. Hemolytic Uremic Syndrome, Post-diarrheal [Internet]. Available from: https://wwwn.cdc. gov/nndss/ conditions/hemolytic-uremic-syndrome-post-diarrheal/.
4. Makovetskaia G.A., Mazur L.I., Gasilina E.S., Borisova O.V., Barinov V.N. Health monitoring of children who have undergone hemolytic uremic syndrome as a measure to prevent the development and progression of chronic kidney disease. Pediatriia. Zhurnalim. G. N. Speranskogo. 2011; 90(3):6— 12. (In Russ.)
5. Karpovich G.S., Krasnova E.I., Vasiunin A.V., Komissarova T.V., Enivatova L.I, Gaints O.V.Hemolyticuremicsyndrome. Possible etiological role of the infection caused by Campylobacter. Almanakh Кlinicheskoi Мeditsiny. 2020; 48(4):246—253. doi: 10.18786/2072-0505-2020-48-017 (In Russ.)
6. Gunkova E.V. Hemolytic uremic syndrome in children: prediction and diagnosis of outcomes: Abstract. Ph.D. of Medical Sciences thesis. Orenburg, 2021. (In Russ.)
7. Baiko S.V., Samoilovich E.O., Semeiko G.V., Cherednichenko M.D. Outbreak of hemolytic uremic syndrome in children in Belarus: epidemiology, features of the clinical course and laboratory changes, outcomes. Pediatriia. Vostochnaia Evropa. 2022; 12(3):301—312. (In Russ.)
8. Joseph A; Cointe A; MarianiKurkdjian, Rafat C, Hertig A. Shiga toxin-associated hemolytic uremic syndrome: A narrative review. Toxins (Вasel). 2020 Jan 21; 12(2):67. doi: 10.3390/toxins12020067.
9. Lisboa L.F; Szelewicki J; Lin A, Latonas S, Li V, Zhi S, Parsons BD, Berenger B, Fathima S, Chui L.. Epidemiology of Shiga toxin-producing Escherichia coli O157 in the province of Alberta, Canada, 2009—2016. Toxins (Вasel), 2019 Oct 22; 11(10):613. doi: 10.3390/toxins11100613.
10. Clinical guidelines.Hemolytic uremic syndrome Approved by the Ministry of Health of the Russian Federation.18.01—2022. 2022: 84. (In Russ.)
11. Semeiko G.V., Samoilovich E.O., Baiko S.V., Cherednichenko M.D. Etiological diagnosis of postdiarrheal hemolytic uremic syndrome in children using TaqMan Array maps. Pediatriia. Vostochnaia Evropa. 2022; 11(4):511— 520. (In Russ.)
12. Dolgikh T.I., Voitovich M.A., Galileiskaia S.B., Lazareva L.I. Verotoxin — laboratory marker of Escherichia coli O:157 intestinal infection complicated by hemolytic uremic syndrome in young children. Sibirskii Мeditsinskii Zhurnal. 2009; (8):75—76. (In Russ.)
13. Gaudry S, Hajage D, Benichou N, Chaïbi K, et al. Delayed versus early initiation of renal replacement therapy for severe acute kidney injury: A systematic review and individual patient data meta-analysis of randomised clinical trials. Lancet. 2020 May 9; 395(10235):1506—1515. doi: 10.1016/S0140-6736 (20)30531-6.
14. Fakhouri F, Zuber J, Frémeaux-Bacchi V, Loirat C. Haemolyticuraemicsyndrome. Lancet. 2017 Aug 12; 390(10095):681—696. doi: 10.1016/S0140-6736(17)30062-4
15. Gunkova E.V., Zorin I.V., Vialkova A.A. Clinical characteristics of hemolytic uremic syndrome in children of Orenburg region. Lechashchii Vrach. 2018; 8:48—51. (In Russ.)
16. ShpikalovaI.Iu., Pankratenko T.E., EmirovaKh.M., Zverev D.V., Tolstova E.M. CNS involvement in patients with Shiga-toxin associated hemolytic uremic syndrome (STEC-HUS): current aspects of pathogenesis, symptomatology and treatment strategy (Literature review). Nefrologiia i Dializ. 2014; 16(3):328—338. (In Russ.)
17. Molochkova O.V., Orekhova S.B., Ovechkin R.V., Vyshlova V.S., et al. A case of hemolytic-uremic syndrome that developed in a 5-year-old child due to acute intestinal infection with hemocolitis. Detskie Infektsii=Children Infections. 2024; 23(1):62—67. (In Russ.) https://doi.org/10.22627/2072-8107-2024-23-1-62-67
Review
For citations:
Belan Yu.B., Gashina E.A., Lobova E.F., Puzyreva L.V., Merson I.S. Clinical cases of hemolytic-uremic syndrome in children with E. coli infection. CHILDREN INFECTIONS. 2025;24(2):34-38. (In Russ.) https://doi.org/10.22627/2072-8107-2025-24-2-34-38
Views:
45
Email this article 