CNS Pathology in Children with Enterovirus-71 Infection during Epidemic and Interepidemic Periods

Abstract

The purpose of research — improvement of CNS pathology diagnostic in children with enterovirus-71 infection during epidemic and interepidemic periods. The study involved 64 patients with enterovirus-71 infection at the age from 6 months to 14 years with CNS pathology, including 52 patients during epidemic period and 12 children during interepidemic period. The disease is characterized by the appearance at the first two days of fever, murrian-like, catarrhal, lymphoproliferative syndromes. On the third day of illness joined symptoms of meningitis, meningoencephalitis, encephalomyelopoliradiculoneuropathy and neuropathy. CNS pathology during interepidemic period often occurs in children with burdened history, not attending organized groups, is characterized by high frequency ncephalomyelopoliradiculoneuropathy and neuropathy, often associated with febrile fever and splenomegaly, a rare manifestation murrian-like syndrome. These features should be considered in the disease diagnosis during epidemic and interepidemic periods