Anti-adhesive Strategy in Development of Combined Antidiphtheritic Vaccine as a Perspective Preventive Measure of Corynebacteria diphtheriae Circulation Among the Population
https://doi.org/10.22627/2072-8107-2015-14-3-30-33
Abstract
A study is devoted to the development of new bacterial diphtheria vaccines aimed at prevention adhesion of microbial cells to host’s pharyngeal epithelial cells and thus limit colonization of mucous membranes, bacteria carrier state formation and promoted to C. diphtheriaе circulation decrease among the population. As a base of the candidate-vaccine we suggest the diphtheria bacterial antigenic preparation obtained by use of electro-magnetic radiation of ultrahigh frequency from a culture of C. diphtheriaе, var. gravis, tox +.
About the Authors
I. V. Yelyseyeva
State Institution «Mechnikov Institute of Microbiology and Immunology of National Academy of Medical Science of Ukraine», Kharkov, Ukraine
Russian Federation
Russian Federation
senior researcher, leading scientific associate of respiratory infection prevention laboratory, State Institution «Mechnikov Institute of Microbiology and Immunology of National Academy of Medical Science of Ukraine»; Pushkinskaya Str., 14/16, Kharkov, Ukraine, 61057
Ye. M. Babich
State Institution «Mechnikov Institute of Microbiology and Immunology of National Academy of Medical Science of Ukraine», Kharkov, Ukraine
Russian Federation
Russian Federation
L. A. Zhdamarova
State Institution «Mechnikov Institute of Microbiology and Immunology of National Academy of Medical Science of Ukraine», Kharkov, Ukraine
Russian Federation
Russian Federation
V. I. Belozersky
State Institution «Mechnikov Institute of Microbiology and Immunology of National Academy of Medical Science of Ukraine», Kharkov, Ukraine
Russian Federation
Russian Federation
Ye. Yu. Isayenko
State Institution «Mechnikov Institute of Microbiology and Immunology of National Academy of Medical Science of Ukraine», Kharkov, Ukraine
Russian Federation
Russian Federation
S. A. Kolpak
State Institution «Mechnikov Institute of Microbiology and Immunology of National Academy of Medical Science of Ukraine», Kharkov, Ukraine
Russian Federation
Russian Federation
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Review
For citations:
Yelyseyeva I.V., Babich Ye.M., Zhdamarova L.A., Belozersky V.I., Isayenko Ye.Yu., Kolpak S.A. Anti-adhesive Strategy in Development of Combined Antidiphtheritic Vaccine as a Perspective Preventive Measure of Corynebacteria diphtheriae Circulation Among the Population. CHILDREN INFECTIONS. 2015;14(3):30-33. (In Russ.) https://doi.org/10.22627/2072-8107-2015-14-3-30-33
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