THE SIGNIFICANCE OF QUANTITIES DETECTION OF СORE ANTIGEN IN BLOOD SERUM OF CHILDREN WITH HEPATITIS C
https://doi.org/10.22627/2072-8107-2014-13-2-8-12
Abstract
The clinical and pathogenetic significance of determining HCV core-antigen (HCV core-Ag) in serum of children with hepatitis C was investigated firstly. A direct correlation between the concentration of HCV core-Ag and viral load (VL) was revealed (r = 0,91). Children with high core-Ag (above 2500 fmol/L) showed indirect evidence for the immunosuppressive action of HCV core-Ag and occurrence of liver fibrosis more frequent (p < 0,05). In this grouP of children the prevalence of HCV subtype 3a was revealed (p < 0,05).
About the Authors
A. Leybman
Russian National Research Medical University named after N. I. Pirogov, Moscow;
Research Institute of Virology named after D. I. Ivanovsky, Moscow
Russian Federation
Russian Federation
L. I. Nikolaeva
Research Institute of Virology named after D. I. Ivanovsky, Moscow
Russian Federation
Russian Federation
G. V. Sapronov
Russian Medical Academy of Post-Degree Education Moscow
Russian Federation
Russian Federation
E. I. Shestakova
G. N. Speransky Children”s Hospital № 9 Moscow
Russian Federation
Russian Federation
E. I. Samokhvalov
Research Institute of Virology named after D. I. Ivanovsky, Moscow
Russian Federation
Russian Federation
O. B. Kovalev
Russian National Research Medical University named after N. I. Pirogov, Moscow
Russian Federation
Russian Federation
A. G. Pisarev
Russian National Research Medical University named after N. I. Pirogov, Moscow
Russian Federation
Russian Federation
L. I. Konovalova
G. N. Speransky Children”s Hospital № 9 Moscow
Russian Federation
Russian Federation
A. E. Grishechkin
Research Institute of Virology named after D. I. Ivanovsky, Moscow
Russian Federation
Russian Federation
V. F. Uchaikin
Russian National Research Medical University named after N. I. Pirogov, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Leybman A., Nikolaeva L.I., Sapronov G.V., Shestakova E.I., Samokhvalov E.I., Kovalev O.B., Pisarev A.G., Konovalova L.I., Grishechkin A.E., Uchaikin V.F. THE SIGNIFICANCE OF QUANTITIES DETECTION OF СORE ANTIGEN IN BLOOD SERUM OF CHILDREN WITH HEPATITIS C. CHILDREN INFECTIONS. 2014;13(2):8-12. (In Russ.) https://doi.org/10.22627/2072-8107-2014-13-2-8-12
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