Prevention of Adenovirus Infection with Recombinant Interferon 2b Medication in Preschool Institutions
https://doi.org/10.22627/2072-8107-2016-15-2-9-14
Abstract
This article presents the results of experimental (on cell cultures) and clinical (in children’s groups) studies of recombinant interferon alpha-2b medication (Grippferon). Our aim was to examine the virus-inhibitory activity of this medication (against adenovirus) and its preventive effect (on causative agents of ARVI), which allows us to use this medication as a preventive measure against adenovirus (as well as any other) infection in children’s groups.
About the Authors
L. V. OsidakRussian Federation
Dr Med. Sci., Professor, leading researcher, division of respiratory viral infections in children, Research Institute of Influenza, Ministry of Healthcare of the Russian Federation; 196237, St. Petersburg, 15/17 Prof. Popov st.; +7(812) 499-15-40
M. A. Yanina
Russian Federation
V. V. Zarubaev
Russian Federation
E. S. Goncharova
Russian Federation
O. A. Alexeeva
Russian Federation
References
1. K. Bojang, MDS. Walters. [Toxic shock-like syndrome caused by adenovirus infection] // Archives of Disease in Childhood: short reports. 1992. P. 1112—1114.
2. Garnett C.T., Talekar G., Mahr J.A. [Latent Species C Adenoviruses in Human Tonsil Tissues] // Journal of Virology. Mar. 2009. P. 2417—2428.
3. Jin A. Lee, Nam Hee Kim, Sun Jung Kim. [Rapid Identification of Human Adenovirus Types 3 and 7 from Respiratory Specimens via Multiplex Type-Specific PCR] // Journal of Clinical Microbiology. Nov. 2005. P. 5509—5514.
4. Andria M. Pihos. [Epidemic keratoconjunctivitis: A review of current concepts in management] // Journal of Optometry. V. 6, Issue 2, April–June 2013. P. 69—74.
5. G. Cukor, Human R.N. Blacklow. [Viral Gastroenteritis] // Microbiological Reviews. June 1984. P. 157—179.
6. Tram T.N. et al. [Fatal Disseminated Adenovirus Infections in Immunocompromised Patients] // American Journal of Clinical Pathology. 2003/120:575-583.
7. Янина М.А., Комиссаров А.Б, Осидак Л.В., Львов Н.И. Определение генотипов аденовируса в образцах, полученных от больных ОРВИ / Молекулярная диагностика: Сб. трудов. — Изд. МБА. — 2014. Т.1. 336 с. Yanina M.A., Komissarov A.B., Osidak L.V, Lvov N.I. [Detection of adenoviral genotypes in specimens from patients with ARVI] / Molecular diagnostic: Collection of research papers. — pub. MBA. 2014. V.1. p. 336. (In Russ.)
8. Ершов Ф.И., Киселев О.И. Интерфероны и их индукторы (от молекул до лекарств). — М «ГЭОТАР-Медиа», 2005. 368 с. Ershov F.I., Kiselev O.I. [Interferons and immune modulation (from molecule to remedy)]. — М.: «GEOTAR -Меdia», 2005. — 368 p. (In Russ.)
9. Острые респираторные инфекции у детей и подростков: Практическое руководство для врачей / под редакцией Л.В. Осидак, 3-ое издание, дополненное. — С.-Пб.: ИнформМед, 2014. 255 с. [Acute respiratory infections in children and adolescents]: Practice guidelines for physicians. Under the editorship of L.V. Osidak. — S-Pb.: Inform.Med, 2014. p. 255. (In Russ.)
10. Goodbourn S., Didcock L., Randall R.E. [Interferons: cell signalling, immune modulation, antiviral responses and virus countermeasures] // J. Gen.Virol. 2000. 81:2341-2364.
11. Головачева Е.Г. Концептуально-диагностические закономерности иммунного ответа при гриппе. Иммунокоррекция в терапии и вакцинопрофилактике: Автореф. дисс. ... д.м.н. — Спб, 2015. Golovacheva E.G. [Conceptually-diagnostic trends of immune response in case on influenza. Immunocorrection in therapy and vaccine prophylaxis]: Review ... DMS. — S-Pb., 2015. (In Russ.).
Review
For citations:
Osidak L.V., Yanina M.A., Zarubaev V.V., Goncharova E.S., Alexeeva O.A. Prevention of Adenovirus Infection with Recombinant Interferon 2b Medication in Preschool Institutions. CHILDREN INFECTIONS. 2016;15(2):9-14. (In Russ.) https://doi.org/10.22627/2072-8107-2016-15-2-9-14