Prevention of Antibiotic-associated Diarrhea in Children with Lactobacillus Probiotic
https://doi.org/10.22627/2072-8107-2016-15-4-112-118
Abstract
The data on the frequency of the spread of antibiotic-associated diarrhea (AAD) in children. A different incidence of AAD in children of different age groups, highest in children under the age of 3 years.
The possibility of reducing the frequency of its development when administered prophylactically domestic probiotic containing Lactobacillus — Acipol on the background of antibiotic therapy. Prophylactic Acipol can reduce the incidence of AAD in these patients is 21%, and reduce the duration and severity of diarrheal syndrome.
About the Authors
O. V. Molochkova
Russian National Research Medical University after N.I. Pirogov of the Ministry of Health of the Russian Federation,
Morozovskaya Children's Clinical Hospital
Russian Federation
Russian Federation
CMS, Associate Professor, the Department of Infectious Diseases in Children,
Moscow
O. V. Kladova
Russian National Research Medical University after N.I. Pirogov of the Ministry of Health of the Russian Federation,
Morozovskaya Children's Clinical Hospital
Russian Federation
Moscow
Russian Federation
Moscow
A. A. Novokshonov
Russian National Research Medical University after N.I. Pirogov of the Ministry of Health of the Russian Federation,
Morozovskaya Children's Clinical Hospital
Russian Federation
Moscow
Russian Federation
Moscow
N. L. Waltz
Russian National Research Medical University after N.I. Pirogov of the Ministry of Health of the Russian Federation,
Morozovskaya Children's Clinical Hospital
Russian Federation
Moscow
Russian Federation
Moscow
Yu. V. Kompaniets
Russian National Research Medical University after N.I. Pirogov of the Ministry of Health of the Russian Federation,
Morozovskaya Children's Clinical Hospital
Russian Federation
Moscow
Russian Federation
Moscow
N. L. Grishkevich
Russian National Research Medical University after N.I. Pirogov of the Ministry of Health of the Russian Federation,
Morozovskaya Children's Clinical Hospital
Russian Federation
Moscow
Russian Federation
Moscow
References
1. Bartlett J.G. Antibiotic-associated diarrhea // N Engl J Med. 2002; 346:334—9.
2. Mc. Farland L.V. Diarrhea acquired in the hospital // Gast Clin North Am. 1993; 22: 563—77.
3. В.А. Малов. Антибиотикоассоциированные диареи // Кл. микроб. и антимикр. химиотер. 2002; 1: 22—32. Malov V.A. Antibioticassociated diarrhea // Cl. Microb and Antimicr Himioter. 2002; 1: 22—32. (In Russ.)
4. B.C. Johnston, A.L. Supina, M. Ospina, S. Vohra. Probiotics for the prevention of pediatric antibioticassociated diarrhea // Cochrane Database Syst Rev. 2007, Apr. 18; (2): CD004827.
5. D’Souza A.L., Rajkumar C., Cooke J., Bulpitt C.J. Probiotics in prevention of antibiotic associated diarrhea: meta-analysis // BMJ. 2002; 324: 1361.
6. B.C. Johnston, A.L. Supina, S. Vohra. Probiotics for pediatric antibioticassociated diarrhea: a metaanalysis of randomized placebocontrolled trials // CMAJ. 2006 Aug 15; 175 (4): 377—83. Erratum in: CMAJ. 2006, Sep. 26; 175 (7): 777.
7. M. La Rosa et al. Prevention of antibioticassociated diarrhea with Lactobacillus sporogens and fructooligosaccharides in children. A multicentric doubleblind vs placebo studyMinerva // Pediatr. 2003, Oct; 55 (5): 447—52.
8. Ивашкина Н.Ю., Ботина С. Г. Оригинальный отечественный пробиотик аципол: молекулярно-биологические и метаболические характеристики // РЖГГК. 2009; 2: 58—64. Ivashkina N.Y., Botina S.G. The original domestic probiotic Acipol: molecular biology and metabolic characteristics // RJHGK. 2009; 2: 58—64. (In Russ.)
9. Феклисова Л.В. Результаты применения пробиотика Аципол® у детей с различной инфекционной патологией // Педиатрия. 2008; 6: 87—92. Feklisova L.V. The results of the application of probiotic Acipol® in children with various infectious pathologies // Pediatrics. 2008; 6: 87—92. (In Russ.)
10. Буланова И.А., Феклисова Л.В., Титова Л.В. Результаты применения лактосодержащих пробиотиков при вирусных диареях у детей раннего возраста // Детские инфекции. 2009; 8(2): 58—60. Bulanova I.A., Feklisova L.V., Titova L.V. The results of the application of probiotics laktosoderzhaschih viral diarrhea in infants // Childrens Infections. 2009; 8(2): 58-60. (In Russ.)
11. Новокшонов А.А., Соколова Н.В., Бережкова Т.В., Сахарова А.А., Ларина Т.С. Клиническая эффективность и воздействие на микробиоценоз кишечника пробиотика Аципол в комплексной терапии острых кишечных инфекций у детей // Педиатрия. 2007; 2: 87—92. Novokshonov A.A., Sokolova N.V., Berezhkova T.V., Sakharova A.A., Larina T.S. Clinical efficacy and effects on intestinal microbiocenosis Acipol probiotics in the treatment of acute intestinal infections in children // Pediatrics. 2007; 2: 87—92. (In Russ.)
12. Кладова О.В., Ивашкина Н.Ю., Шустер А.М., Мартьянов В.А. и др. Профилактическая и терапевтическая эффективность Аципола при антибиотико-ассоциированной диарее у детей // Детские инфекции. 2009; 8(1): 44—47. Kladova O.V., Ivashkina N.Yu., Shuster A.M., Martianov V.A. et al. Prophylactic and therapeutic efficacy of Acipol with antibiotic-associated diarrhea in children // Childrens Infections. 2009; 8(1): 44—47. (In Russ.)
13. О.В. Кладова, О.В. Молочкова, Л.А. Пронина, Л.В. Глазунова и др. Опыт использования лактосодержащего пробиотика при инфекционных заболеваниях у детей, получающих антибактериальную терапию // Детские инфекции. 2013; 12(3): 56-61. Kladova O.V., Molochkova O.V., Pronina L.A., Glazunova L.V. at al. Experience of using laktoprobiotics in infectious diseases in children receiving antibiotics // Childrens Infections. 2013; 12(3): 56—61. (In Russ.)
Review
For citations:
Molochkova O.V., Kladova O.V., Novokshonov A.A., Waltz N.L., Kompaniets Yu.V., Grishkevich N.L. Prevention of Antibiotic-associated Diarrhea in Children with Lactobacillus Probiotic. CHILDREN INFECTIONS. 2016;15(4):37-41. (In Russ.) https://doi.org/10.22627/2072-8107-2016-15-4-112-118
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