LIMBIC ENCEPHALITIS OF HERPESVIRUS ETIOLOGY
https://doi.org/10.22627/2072-8107-2014-13-4-6-13
Abstract
Based on the literature data and our personal observations in the article discusses the types of variants of the course of nervous system caused by herpesviruses. In the description of a clinical case demonstrated a classic example of limbic encephalitis infectious etiology. The study involved 36 children with various neurological and infectious diseases: 19 children with the diagnosis - convulsions, 8 children with the diagnosis — epilepsy, 5 children with acute viral encephalitis, 3 children with neuropathies. It was established that in the genesis of diseases such as epilepsy, convulsive syndrome, limbic encephalitis, neuropathy peripheral nerves leading role belongs to of herpes virus infection, in which the dominant role belongs HHV-6 infection. Pathogenetically proved the impact of the virus on the receptor apparatus of glia with the disorder of the functional state of mitochondria of these cells. According to our own observations provided data that result in persistence of HHV-6 variant-in mono or in combination with other herpesviruses growing threat of epilepsy and other neurological disorders.
About the Authors
E. V. Simonova
Russian National Research Medical University named after N.I. Pirogov, Moscow, Russia
Russian Federation
post-graduate student of Department of infectious diseases in children № 1 of the pediatric faculty; Russian National Research Medical University named after N. I. Pirogov; 117049, Moscow, 4th Dobryninsky
Russian Federation
post-graduate student of Department of infectious diseases in children № 1 of the pediatric faculty; Russian National Research Medical University named after N. I. Pirogov; 117049, Moscow, 4th Dobryninsky
F. S. Kharlamova
Russian National Research Medical University named after N.I. Pirogov, Moscow, Russia
Russian Federation
Russian Federation
V. F. Uchaikin
Russian National Research Medical University named after N.I. Pirogov, Moscow, Russia
Russian Federation
Russian Federation
I. M. Drozdova
Morozovsky Children’s Clinical Hospital
Russian Federation
Russian Federation
L. P. Semenova
Morozovsky Children’s Clinical Hospital
Russian Federation
Russian Federation
A. E. Andzhel
Morozovsky Children’s Clinical Hospital
Russian Federation
Russian Federation
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Review
For citations:
Simonova E.V., Kharlamova F.S., Uchaikin V.F., Drozdova I.M., Semenova L.P., Andzhel A.E. LIMBIC ENCEPHALITIS OF HERPESVIRUS ETIOLOGY. CHILDREN INFECTIONS. 2014;13(4):6-13. (In Russ.) https://doi.org/10.22627/2072-8107-2014-13-4-6-13
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