THE DRUG-INDUCED HEPATITIS IN CHILDREN
https://doi.org/10.22627/2072-8107-2017-16-1-42-51
Abstract
Among toxic lesions of the liver, an important place belongs to medicinal hepatitis. Among patients with hepatitis, drug disease of the liver occurs in 0.7—1.4% of cases, and in the presence of jaundice — in 5%. A family case of sisters 9 and 4-year-old life development of acute drug hepatitis caused by ibuprofen in a daily dose of 32 mg / kg (total 3.2 g) and 25 mg / kg (total 2 g), respectively, was demonstrated in siblings. Hepatitis developed after an acute respiratory infection. Weakness, nausea, vomiting, jaundice of the skin and sclera, pruritus, multiple increase in serum transaminases and markers of cholestasis are revealed. Viral hepatitis and some hereditary liver diseases were excluded. The drug lesion of the liver was of a mixed nature: hepatocellular (cytotoxic) and cholestatic. Timely administration of therapy (detoxification, glucocorticosteroids, ursodeoxycholic acid (Ursosan) led to a regression of clinical symptoms of the disease and positive dynamics of laboratory indicators.
About the Authors
O. V. Molochkova
Russian National Research Medical University named after N.I. Pirogov
Russian Federation
Russian Federation
Molochkova Oksana — PhD, Associate Professor of the Department of Infectious Diseases in Children.
Moscow, 7 (499) 256-60-26; сi-journal@mail.ru
O. B. Kovalev
Russian National Research Medical University named after N.I. Pirogov; Children's City Clinical Hospital №9
Russian Federation
Russian Federation
Moscow
V. F. Uchaykin
Russian National Research Medical University named after N.I. Pirogov
Russian Federation
Russian Federation
Moscow
V. A. Konev
Russian National Research Medical University named after N.I. Pirogov
Russian Federation
Moscow
Russian Federation
Moscow
Yu. S. Snetkova
Children's City Clinical Hospital №9
Russian Federation
Russian Federation
Moscow
References
1. Шульпекова Ю.О. Лекарственные поражения печени // Consilium medicum. 2006; 8(7):5—6. Shulpekova Yu.O. [Medicinal lesions of the liver] // Consilium Medicum. 2006; 8 (7): 5—6. (In Russ.)
2. Aithal P.G., Day C.P. [The natural history of histologically proved drug induced liver disease] // Gut. 1999; 44: 731—735.
3. Navarro V.J.,Senior J.R. [Drug-RelatedHepatotoxicity] // N Engl J Med .2006; 354: 731—9.
4. Постников С.С., Грацианская А.Н., Костылева М.Н., Татаринов П.А. Лекарственные болезни печени // Педиатрия. 2012; 91(4): 126—131. Postnikov S.S., Gratsianska A.N., Kostyleva M.N., Tatarinov P.A. [Drug-induced diseases of the liver] // Pediatrics. 2012; 91(4): 126—131. (In Russ.)
5. Инструкция к препарату Нурофен для детей. http://www.rlsnet.ru/tn_index_id_9583.htm The Instruction on Nurofen for children. http://www.rlsnet.ru/tn_index_id_9583.htm (In Russ.)
6. Запруднов А.М., Григорьев К.И., Мазанкова Л.Н., Харитонова Л.А. Эффективность и безопасность применения препарата Нурофен для детей // Детский доктор. 2001; 2: 23—25. Zaprudnov A.M., Grigoriev K.I., Mazankova L.N., Kharitonova L.A. [Efficacy and safety of Nurofen for children] // Children's Doctor. 2001; 2: 23—25. (In Russ.)
7. Евсеев М.А. Гепато– и гастротоксичность нестероидных противовоспалительных препаратов: возможные точки пересечения // РМЖ. 2007; 26: 20—29. Evseev M.A. [Hepato and gastrotoxicity of non-steroidal anti-inflammatory drugs: possible points of intersection] // Russian Medical Journal. 2007; 26: 20—29. (In Russ.)
8. O’Connor N., Dargan P.I., Jones A.L. [Hepatocellular damage from non–steroidal anti–inflammatory drugs] // Q J Med, 2003; 96: 787—791.
9. Traversa G., Bianchi C., DaCas R. [Cohort study of hepatotoxicity associated with nimesulide and other non–steroidal anti–inflammatory drugs] // BMJ, 2003; 327: 18—22.
10. Borel I., Hedelius F., Baumgartner C. et al. [Severe acute hepatitis associated with ibuprofen treatment] // Gastroenterol. Clin. Biol. 2001; 25(4): 430—432.
11. Rodriguez–Gonzalez F.J., Montero J.L., Puente J. et al. [Orthotopic liver transplantation after subacute liver failure induced by therapeutic doses of ibuprofen] // Am J Gastroenterol 2002; 97: 2476–7.
12. Merlani G., Fox M., Oehen H.P., Cathomas G., Renner E.L., Fattinger K., Schneeman M., Kullak–Ublick G.A. [Fatal hepatotoxicity secondary to nimesulide] // Eur J Clin Pharmacol. 2001; 57: 321—6.
13. Mc Cormick P.A., Kennedy F., Curry M. [COX 2 inhibitor and fulminant hepatic failure] // Lancet, 1999; 353: 40—1.
14. Bort R., Ponsoda X., Jover R., et al. [Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity] // J Pharmacol Exp Ther. 1999; 288: 65—72.
15. Рейзис А.Р., Матанина Н.В., Никитина Т.С., Дрондина А.К., Ананьева Н.П., Иванчатенко Г.Н., Загузова Л.И., Федосеев М.А. Применение препаратов урсодеоксихолевой кислоты (урсосана) в лечении острых и хронических вирусных гепатитов (Информационное письмо). — М.: Федеральное государственное учреждение науки «Центральный научно-исследовательский институт эпидемиологии Роспотребнадзора», Рекламно-издательская группа «МегаПро», 2006. www.megapro.ru Reisis A.R., Matanina N.V., Nikitina T.S., Drondina A.K., Ananyeva N.P., Ivanchatenko G.N., Zaguzova L.I., Fedoseev M.A. [The use of drugs ursodeoxycholic acid (ursosana) in the treatment of acute and chronic viral hepatitis] (Information mail). — M: Federal State Institution of Science «Central Research Institute of Epidemiology of Rospotrebnadzor», Advertising and Publishing Group «MegaPro», 2006. www.megapro.ru (In Russ.)
16. Учайкин В.Ф., Молочкова О.В., Писарев А.Г., Чередниченко Т.В., Чаплыгина Г.В. Холестаз при острых и хронических вирусных гепатитах // Детские инфекции. 2014; 13(3): 51—54. Uchaykin V.F., Molochkova O.V., Pisarev A.G., Cherednichenko T.V., Chaplygina G.V. [Cholestasis in acute and chronic viral hepatitis] // Children's Infections. 2014; 13(3): 51—54. (In Russ.)
17. Navau R.M., Neuman M.G. [Ibuprofen-induced hypersensitivity syndrome] // Transl. Res. 2010; 155(6): 275—293.
18. Bennett W.E., Turmelle Y.P., Shepherd R.W. [Ibuprofen-induced liver injury in an adolescent athlete] // Clin. Pediatr. (Phila). 2009; 48(1): 84—86.
19. Navau R.M., Neuman M.G. [Ibuprofen-induced hypersensitivity syndrome] // Transl. Res. 2010; 155(6): 275—293.
20. Taghian M., Tran T.A., Menget A et al. [Acute vanishing bile duct syndrome after ibuprofen therapy in a child] // J. Pediatr. 2004; 145(2): 273—276.
21. Elkrief L., Chryssostalis A., Moachon L. et al. [Severe cholestatic hepatitis associated with Stevens-Johnson syndrome after taking ibuprofen] // Gastroenterol. Clinic. Biol. 2007; 31(11): 1043—1045.
Review
For citations:
Molochkova O.V., Kovalev O.B., Uchaykin V.F., Konev V.A., Snetkova Yu.S. THE DRUG-INDUCED HEPATITIS IN CHILDREN. CHILDREN INFECTIONS. 2017;16(1):42-51. (In Russ.) https://doi.org/10.22627/2072-8107-2017-16-1-42-51
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