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THE DRUG-INDUCED HEPATITIS IN CHILDREN

https://doi.org/10.22627/2072-8107-2017-16-1-42-51

Abstract

Among toxic lesions of the liver, an important place belongs to medicinal hepatitis. Among patients with hepatitis, drug disease of the liver occurs in 0.7—1.4% of cases, and in the presence of jaundice — in 5%. A family case of sisters 9 and 4-year-old life development  of acute drug hepatitis caused by ibuprofen in a daily dose of 32 mg / kg (total 3.2 g) and 25 mg / kg (total 2 g), respectively, was demonstrated in siblings. Hepatitis developed after an acute respiratory infection. Weakness, nausea, vomiting, jaundice of the skin and sclera, pruritus, multiple increase in serum transaminases and markers of cholestasis are revealed. Viral hepatitis and some hereditary liver diseases were excluded. The drug lesion of the liver was of a mixed nature: hepatocellular (cytotoxic) and cholestatic. Timely administration of therapy (detoxification, glucocorticosteroids, ursodeoxycholic acid (Ursosan) led to a regression of clinical symptoms of the disease and positive dynamics of laboratory indicators.

About the Authors

O. V. Molochkova
Russian National Research Medical University named after N.I. Pirogov
Russian Federation

Molochkova Oksana — PhD, Associate Professor of the Department of Infectious Diseases in Children.

Moscow, 7 (499) 256-60-26; сi-journal@mail.ru



O. B. Kovalev
Russian National Research Medical University named after N.I. Pirogov; Children's City Clinical Hospital №9
Russian Federation

Moscow



V. F. Uchaykin
Russian National Research Medical University named after N.I. Pirogov
Russian Federation

Moscow



V. A. Konev
Russian National Research Medical University named after N.I. Pirogov
Russian Federation
Moscow


Yu. S. Snetkova
Children's City Clinical Hospital №9
Russian Federation

Moscow



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Review

For citations:


Molochkova O.V., Kovalev O.B., Uchaykin V.F., Konev V.A., Snetkova Yu.S. THE DRUG-INDUCED HEPATITIS IN CHILDREN. CHILDREN INFECTIONS. 2017;16(1):42-51. (In Russ.) https://doi.org/10.22627/2072-8107-2017-16-1-42-51

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ISSN 2072-8107 (Print)
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