THE IMPORTANCE OF HERPESVIRUSES IN THE ETIOLOGY OF A NUMBER OF INFECTIOUS AND SOMATIC DISEASES OF CHILDREN
https://doi.org/10.22627/2072-8107-2017-16-3-10-19
Abstract
The article is devoted to study the etiological role of herpes viruses in infectious and somatic pathology of children (n = 770) using the complex of methods of laboratory diagnostics. Determined the leading etiological role of HSV in children with neuroinfections (12,7%) during primary infection and in children with intrauterine infection (29,0%) during its reactivation. It is shown that in 50,9% of cases, the diagnosis of «infectious mononucleosis» confirmed by the detection of markers of acute EBV-infection, and 20,0%, it was replaced by mononucleotides syndrome was discovered markers of acute CMV-infection, and 18,1% — markers of acute HHV-6-infection. The role of HHV-6 as the primary etiologic agent of the disease is established at 36,3% of children admitted with convulsive syndrome on the background of febrile, at 29,1% — a sudden exanthema and 25,5% — with fever of unknown origin.
About the Authors
T. N. Rybalkina
Federal State Research Center of Epidemiology and Microbiology named after N.F. Gamaleya of Russian Ministry of Health
Russian Federation
Russian Federation
PhD, senior research associate, laboratory of epidemiology of opportunistic infections
N. V. Karazhas
Federal State Research Center of Epidemiology and Microbiology named after N.F. Gamaleya of Russian Ministry of Health
Russian Federation
Russian Federation
P. A. Savinkov
Federal State Research Center of Epidemiology and Microbiology named after N.F. Gamaleya of Russian Ministry of Health;
Infectious Clinical Hospital №2 Moscow Health Department
Russian Federation
Russian Federation
R. E. Boshyan
Federal State Research Center of Epidemiology and Microbiology named after N.F. Gamaleya of Russian Ministry of Health;
First Moscow State Medical University named after I.M. Sechenov
Russian Federation
Russian Federation
M. Y. Lysenkova
Federal State Research Center of Epidemiology and Microbiology named after N.F. Gamaleya of Russian Ministry of Health
Russian Federation
Russian Federation
M. N. Kornienko
Federal State Research Center of Epidemiology and Microbiology named after N.F. Gamaleya of Russian Ministry of Health
Russian Federation
Russian Federation
P. A. Veselovsky
Federal State Research Center of Epidemiology and Microbiology named after N.F. Gamaleya of Russian Ministry of Health
Russian Federation
Russian Federation
E. M. Burmistrov
Federal State Research Center of Epidemiology and Microbiology named after N.F. Gamaleya of Russian Ministry of Health
Russian Federation
Russian Federation
T. M. Lebedeva
Russian National Research Medical University named after N.I. Pirogov
Russian Federation
Russian Federation
P. A. Markin
Federal State Research Center of Epidemiology and Microbiology named after N.F. Gamaleya of Russian Ministry of Health;
First Moscow State Medical University named after I.M. Sechenov
Russian Federation
Russian Federation
References
1. Боковой А.Г., Егоров А.И. Герпесвирусные инфекции у детей и родителей: Учебное пособие для студентов, врачей-педиатров, инфекционистов, иммунологов. М.: Центр стратегической конъюнктуры, 2014: 256. [Bokovoy A.G., Egorov A.I. Herpesvirus infections in children and parents: A manual for students, pediatricians, infectionists, immunologists. — Moscow: Center for Strategic Situations, 2014: 256. (In Russ.)]
2. Лешкевич H.A., Прошин В.А., Румянцев А.Г., Тимакова М.В. Состояние здоровья детей и перспективы развития детского здравоохранения в Москве. Российский вестник перинатологии и педиатрии. 2008, 53(1):5—12. [Leshkevich N.A., Proshin V.A., Rumyantsev A.G., Timakova M.V. The state of children's health and prospects for the development of children's health in Moscow. Russian herald of perinatology and pediatrics. 2008, 2008, 53(1):5—12. (In Russ.)]
3. Чернявский О.Б., Абрамова И.В., Полянчикова О.Л. Внутриутробные инфекции у новорождённых, факторы риска. Российский вестник перинатологии и педиатрии. 2009, 1: 88. [Chernyavsky O.B., Abramova I.V., Polyanchikova O.L. Intrauterine infections in newborns, risk factors. Russian herald of perinatology and pediatrics. 2009, 1: 88. (In Russ.)]
4. Кускова Т.К., Белова Е.Г. Семейство герпесвирусов на современном этапе. Лечащий Врач. 2004, 5:64—69. [Kuskova T.K., Belova E.G. The family of herpes viruses at the present stage. Therapist. 2004, 5:64—69. (In Russ.)]
5. Сучков C.B., Маматказина P.P., Черепахина Н.Е., и др. Герпесвирусная инфекция: особенности взаимодействия вируса с системой противовирусного иммунитета. Вопросы гинекологии, акушерства и перинатологии. 2007, 6(3):73—81. [Suchkov S.V., Mamatkazina R.R., Cherepahina N.E., et al. Herpesvirus infection: features of the interaction of the virus with the system of antiviral immunity. Questions of gynecology, obstetrics and perinatology. 2007, 6(3):73—81. (In Russ.)]
6. Самсыгина Г.А. Герпесвирусные инфекции у детей. Педиатрия. 2016, 2:18—23. [Samsygina G.A. Herpesviral infections in children. Pediatrics. 2016, 2:18—23. (In Russ.)]
7. Каражас Н.В., Малышев Н.А., Рыбалкина Т.Н. и др. Современные аспекты герпесвирусной инфекции: Методические рекомендации. Правительство Москвы. Департамент здравоохранения. 2012, 23:1—127. [Karazhas N.V., Malyshev N.A., Rybalkina T.N. at al. Modern aspects of herpesvirus infection: Methodical recommendations. The government of Moscow. Department of Health. 2012, 23:1—127. (In Russ.)]
8. Bravender T. Epstein-Barr virus, cytomegalovirus, and infectious mononucleosis. Adolesc. Med. State Art Rev. 2010, 21(2):251—264.
9. Кожевина Г.И. и др. Цитомегаловирусный мононуклеоз у ребенка. Журнал инфектологии. 2010, 2(3):100—101. [Kozhevina G.I. at al. Cytomegalovirus mononucleosis in a child. Journal of Infectology. 2010, 2(3):100—101. (In Russ.)]
10. Galadari I., et al. Rapid detection of IgM and IgG antibodies to herpesviridae virus. Eur. Ann. Allergy Clin. Immunol. 2006, 38(6):198—202.
11. Шамшева О.В., Харламова Ф.С., Егорова Н.Ю., Молочкова О.В., Новосад Е.В., Симонова Е.В., Лебедева Т.М., Гусева Н.А. Результаты многолетнего изучения герпесвирусной инфекции на кафедре инфекционных болезней у детей РНИМУ. Детские инфекции. 2017, 16(2):5-12. DOI:10.22627/2072-8107-2017-16-2-5-
12. [Shamsheva O.V., Kharlamova F.S., Egorova N.Yu., Molochkova O.V., Novosad E.V., Simonova E.V., Lebedeva T.M., Guseva N.A. The results of long-term study of herpesvirus infection in the Department of Infectious Diseases in children RNIMU. Detskie Infektsii=Children's infections. 2017, 16 (2): 5-12. DOI: 10.22627 / 2072-8107-2017-16-2-5-12. (In Russ.)]
13. Харламова Ф.С., Н.Ю. Егорова, О.В. Шамшева, В.Ф. Учайкин, О.В. Молочкова, Е.В. Новосад, Т.М. Лебедева, Е.В. Симонова. Роль герпесвирусной инфекции IV, Vи VI типов в инфекционной и соматической патологии у детей. Педиатрия. 2017; 96 (4): 42—47. DOI: 10.24110/0031-403X-2017-96-4-42-47. [Kharlamova F.S., N.Yu. Egorova, O.V. Shamsheva, V.F. Uchaikin, O.V. Molochkova, E.V. Novosad, T.M. Lebedeva, E.V. Simonovа. The role of herpesvirus infection IV, V and VI types in infectious and somatic pathology in children. Pediatrics. 2017; 96 (4): 42—47. DOI: 10.24110 / 0031-403X-2017-96-4-42-47 (In Russ.)]
14. Olson D., Huntington M.K. Co-infections with cytomegalovirus and Epstein-Barr virus in mononucleosis: case report and review of literature. S D Med. 2009, 62(9):351—353.
15. Савенкова М.С. и др. Лимфаденопатия и лимфаденит у детей: диагностика и лечение. Трудный пациент. 2008, 6(12): 5—9. [Savenkova M.S. at al. Lymphadenopathy and lymphadenitis in children: diagnosis and treatment. Difficult patient. 2008, 6(12): 5—9. (In Russ.)]
16. Половцева Т.В., Каражас Н.В., Калугина М.Ю., Мамедова Е.А. и др. Диагностика герпесвирусной инфекции у детей раннего возраста. Детские инфекции. 2012, 2:51—53. [Polovtseva T.V., Karazhas N.V., Kalugina M.Yu., Mamedova E.A. at al. Diagnosis of herpesvirus infection in young children. Detskie Infektsii=Children's infections. 2012, 2:51—53. (In Russ.)]
17. Вашура Д.В., Савенкова М.С., Заваденко Н.Н., Колтунов И.Е., Каражас Н.В. Рыбалкина Т.Н. и др. Судорожный синдром у детей: роль герпесвирусных инфекций. Детские инфекции. 2014, 4:48—52. [Vashura D.V., Savenkova M.S., Zavadenko N.N., Koltunov I.E., Karazhas N.V., Rybalkina T.N. at al. Convulsive syndrome in children: the role of herpesvirus infections. Detskie Infektsii=Children's infections. 2014, 4:48—52. (In Russ.)]
18. Романцов М.Г., Ершов Ф.И. Часто болеющие дети. Современная фармакотерапия: Руководство для врачей. М: ГЭОТАР-Медиа, 2009: 352. [Romantsov M.G., Ershov F.I. Often ill children. Modern pharmacotherapy: A guide for doctors. M: GEOTAR-Media, 2009: 352. (In Russ.)]
Review
For citations:
Rybalkina T.N., Karazhas N.V., Savinkov P.A., Boshyan R.E., Lysenkova M.Y., Kornienko M.N., Veselovsky P.A., Burmistrov E.M., Lebedeva T.M., Markin P.A. THE IMPORTANCE OF HERPESVIRUSES IN THE ETIOLOGY OF A NUMBER OF INFECTIOUS AND SOMATIC DISEASES OF CHILDREN. CHILDREN INFECTIONS. 2017;16(3):10-19. (In Russ.) https://doi.org/10.22627/2072-8107-2017-16-3-10-19
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