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ON THE ISSUE OF EXPANDING THE INDICATIONS OF THE USE OF AN IMMUNOMODULATING DRUG IN THE TREATMENT AND PREVENTION OF INFLUENZA AND ACUTE RESPIRATORY INFECTIONS IN YOUNG CHILDREN

https://doi.org/10.22627/2072-8107-2017-16-3-54-58

Abstract

The data on the safety and effectiveness of the use of the domestic immunomodulating preparation Polyoxidonium® (azoximer bromide) in children are summarized in the following pages. Polyoxidonium has an immunomodulatory (including interferon-inducing), detoxication and anti-inflammatory effect that allows the clinical course of the disease to be quickly alleviated and the natural immune response modulated. The clinical effectiveness of the drug in acute respiratory infections (ARI) in children, including those with allergic anamnesis. Recent studies have proven the effectiveness of the 7-day course of the preparation Polyoxidonium® for the treatment and prevention of ARI and influenza in children, starting at the age of 3 years, as evidenced by a rapid positive dynamics of clinical symptoms and a 2-fold decrease in ARI frequency compared to placebo group at 6 months after the end of therapy.

 

 

About the Author

V. F. Uchaikin
Russian National Research Medical University named after N.I. Pirogov of the Ministry of Health of the Russian Federation
Russian Federation
Аcademician of the Russian Academy of Sciences, MD, professor of the Department of Infectious Diseases in Children of the Russian National Research Medical University named after N.I. Pirogov of the Ministry of Health of the Russian Federation


References

1. Инфекционная заболеваемость за 2016 г. в РФ. Детские инфекции. 2017; 16(1): 5. [Infectious morbidity in 2016 in the Russian Federation. Detskie Infektsii=Children's Infections. 2017; 16(1): 5. (In Russ.)]

2. Учайкин В.Ф., Нисевич Н.И., Шамшева О.В. Инфекционные болезни и вакцинопрофилактика у детей: Учебник для ВУЗов. М.:ГЭОТАР-Медиа, 2006:688. [Uchaikin V.F., Nisevich N.I., Shamsheva O.V. Infectious diseases and vaccine prophylaxis in children: Textbook for High Schools. M.: GEOTAR-Media, 2006: 688. (In Russ.)]

3. Воробьева Д.А., Гусева Л.Н., Колтунов И.Е., Буллих А.В., Яцышина С.Б., Шипулин Г.А., Туманова Е.Л., Малышев Н.А., Учайкин В.Ф. Поражение легких при гриппе у детей. Детские инфекции. 2014;13(4):46—50. DOI:10.22627/2072-8107-2014-13-4-46-50. [Vorobyeva D.A., Guseva L.N., Koltunov I.E., Bullih A.V., Yatsyshina S.B., Shipulin G.A., Tumanova E.L., Malyshev N.A., Uchaykin V.F. Lungs damage in children with influenza. Detskie Infektsii=Children's Infections. 2014;13(4):46—50. (In Russ.) DOI:10.22627/2072-8107-2014-13-4-46-50]

4. Харламова В.С., Учайкин В.Ф., Кузьменко Л.Г. и др. Опыт применения иммуномодулятора Полиоксидоний для лечения ОРИ у детей. Эффективная фармакотерапия. 2013; 11:12—20. [Kharlamovа F.S., Uchaikin V.F., Kuzmenko L.G. et al. Experience of polioksidony immunomodulator for the treatment of acute respiratory infections in children. Effective Pharmacotherapy. 2013; 11:12—20. (In Russ.)]

5. Булгакова В.А. Практика клинического применения азоксимера бромида (Полиоксидоний®) для терапии и профилактики респираторных инфекций. Российский Аллергологический Журнал, 2014; 3. [Bulgakovа V.A. The practice of clinical applications azoximer bromide (Polioksidoniy®) for the treatment and prevention of respiratory infection. Russian Allergology Journal. 2014; 3. (In Russ.)]

6. Пинегин Б.В., Варфоломеева М.И. Влияние иммуномодулятора на синтез интерферонов. Лечащий врач, 2010; 10. [Pinegin B.V., Varfolomeeva M.I. Influence of the synthesis of interferon immunomodulator. The Аttending Рhysician, 2010; 10. (In Russ.)]

7. Вавилова В.П., Чернюк О.С., Караульнова Т.А., Тарасов Н.И. Новые пути влияния на местные факторы защиты у детей с патологией лимфоглоточного кольца. Лечащий врач, 2011; 6:1—4. [Vavilovа V.P., Chernyuk O.S., Karaulnova T.A., Tarasov N.I. New ways to influence the local protective factors in children with pathology lymphopharyngeal ring. The Аttending Рhysician, 2011; 6:1—4. (In Russ.)]

8. Кунельская Н.Л., Изотова Г.Н., Лучшева Ю.В., Шадрин Г.Б. Коррекция местного иммунитета в ЛОР-практике. Медицинский совет. 2015; 3:40—44. [Kunelskaya N.L., Izotova G.N., Luchsheva Yu.V., Shadrin G.B. Correction of local immunity in otorhinolaryngological practice. Medical Аdvice. 2015; 3: 40—44. (In Russ.)] DOI: http://dx.doi.org/10.21518/2079-701X-2015-3-40-44

9. Вавилова В.П., Вавилов А.М., Черкаева А.Х. Возможности современной терапии острых респираторных вирусных инфекций у детей. Consilium Medicum. Педиатрия (Прил.). 2015; 3: 62—67. [Vavilova V..P, Vavilov A.M., Cherkayeva A.Kh. Possibilities of modern therapy of acute respiratory viral infections in children. Consilium Medicum. Pediatrics (Attached). 2015; 3: 62—67. (In Russ.)]

10. Колосова Н.Г. Острые респираторные инфекции у часто болеющих детей: рациональная этиотропная терапия. РМЖ. 2014; 3: 204—7. [Kolosova N.G. Acute respiratory infections in children often ill: rational etiotropic therapy. Russian Medical Journal. 2014; 3: 204—7. (In Russ.)]

11. Харит С.М., Галустян А.Н. Азоксимера бромид — безопасный и эффективный препарат при лечении острых респираторных инфекций верхних дыхательных путей у детей: обзор результатов двойных слепых плацебо-контролируемых рандомизированных клинических исследований II—III фазы. С.-Петербург, 2017. [Harit S.M., Galustyan A.N. Azoximer bromide is a safe and effective drug in the treatment of acute respiratory infections of the upper respiratory tract in children: an overview of the results of double-blind, placebo-controlled, randomized clinical trials of Phase II—III. St. Petersburg, 2017. (In Russ.)] http://petrovax.ru/press_centre/ news/2017/1235/


Review

For citations:


Uchaikin V.F. ON THE ISSUE OF EXPANDING THE INDICATIONS OF THE USE OF AN IMMUNOMODULATING DRUG IN THE TREATMENT AND PREVENTION OF INFLUENZA AND ACUTE RESPIRATORY INFECTIONS IN YOUNG CHILDREN. CHILDREN INFECTIONS. 2017;16(3):54-58. (In Russ.) https://doi.org/10.22627/2072-8107-2017-16-3-54-58

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ISSN 2072-8107 (Print)
ISSN 2618-8139 (Online)