The State of the Immune System in Сhildren with Bronchial Asthma who are at the Stage of Balneological Rehabilitation
https://doi.org/10.22627/2072-8107-2018-17-4-12-17
Abstract
Decrease in a-interferon (IFN-a) levels by 6.8% (p > 0.05) compared to the control group, IFN-g by 37.7% (p < 0.05), relative quantity of CD8 + lymphocytes — by 12.26% (p < 0.001) and an increase in the relative amount of CD4 + lymphocytes by 3.9% and CD95 + lymphocytes by 49.73% (p < 0.01), IgE levels 4.1 — fold (p < 0.001) and IL-4 — on 30% it was revealed in 36 children with bronchial asthma, who came to sanatorium-and-spa treatment. An increase in IFN-a levels by 74.7% (p < 0.01) compared with baseline, IFN-g 2.1 — fold (p < 0.001), relative CD8 + lymphocyte count — by 12.26% (p < 0.001) and a significant decrease in the relative amount of CD4 + lymphocytes — by 4.8% (p < 0.05) and CD95 + lymphocytes — by 23.84% (p < 0.01), IgE levels by 28.1% (p < 0.01) and IL-4 — 2.3 times observed after the using a drug containing a2b-interferon and antioxidants vitamins E and C — VIFERON® in the process of balneological treatment.
About the Authors
N. N. Kaladze
Crimean Federal University named after V.I. Vernadsky;
Medical Academy named after S.I. Georgievsky
Russian Federation
Russian Federation
Nikolai N. Kaladze, MD, professor, head of the Department of pediatrics, physiotherapy and balneologia
Simferopol, Republic of Crimea
A. I. Ezernitskaya
Crimean Federal University named after V.I. Vernadsky;
Medical Academy named after S.I. Georgievsky
Russian Federation
Russian Federation
Aleksandra Ezernitskaya, graduate student
Simferopol, Republic of Crimea
M. L. Babak
Crimean Federal University named after V.I. Vernadsky;
Medical Academy named after S.I. Georgievsky
Russian Federation
Russian Federation
Marina Babak, PhD, associate professor
Simferopol, Republic of Crimea
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Review
For citations:
Kaladze N.N., Ezernitskaya A.I., Babak M.L. The State of the Immune System in Сhildren with Bronchial Asthma who are at the Stage of Balneological Rehabilitation. CHILDREN INFECTIONS. 2018;17(4):12-17. (In Russ.) https://doi.org/10.22627/2072-8107-2018-17-4-12-17
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