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Pediatric autoimmune neuropsychiatric disorder associated with Streptococcal infection (PANDAS syndrome): real-world practice and clinical case

https://doi.org/10.22627/2072-8107-2019-18-3-53-56

Abstract

Group A beta-hemolytic streptococcus is one of the most important infectious agents leading to both direct damage to organs, and to various cross-reactions with body antigens. One of these forms, manifested by the defeat of subcortical ganglia, is PANDAS syndrome. This paper describes the international criteria and clarifies the differences between this disorder and other forms of brain damage. Paper also describes the clinical case of PANDAS syndrome in a 7-year-old child.

About the Authors

T. L. Uspenskaya
Yaroslavl State Medical University
Russian Federation
MD, PhD, Department of Pediatrician №2


T. V. Vinogradova
Yaroslavl State Medical University
Russian Federation
Department of Pediatrician №2


S. L. Ipatova
Yaroslavl Regional Pediatric Clinical Hospital
Russian Federation
Head of Department of Neurology


E. P. Sitnikova
Yaroslavl State Medical University
Russian Federation
MD, Head of Department of Pediatrician №2


D. S. Kasatkin
Yaroslavl State Medical University
Russian Federation
MD, Professor, Department of Neurology


References

1. Swedo S.E., Leonard H.L, Garvey M., Mittleman B., Allen A.J., Perlmutter S., Lougee L., Dow S., Zamkoff J., Dubbert B.K. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases. Am J Psychiatry. 1998 Feb;155(2):264—271.

2. Singer H.S., Gilbert D.L., Wolf D.S., Mink J.W., Kurlan R. Moving from PANDAS to CANS. J Pediatr. 2012 May;160(5):725—731. doi: 10.1016/j.jpeds.2011.11.040

3. Esposito S., Bianchini S., Baggi E., Fattizzo M., Rigante D. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: an overview. Eur J Clin Microbiol Infect Dis. 2014 Dec; 33(12):2105—2109. doi: 10.1007/s10096-014-2185-9

4. Gabbay V., Coffey B.J., Babb J.S,. Meyer L., Wachtel C., Anam S., Rabinovitz B. Pediatric autoimmune neuropsychiatric disorders associated with streptococcus: comparison of diagnosis and treatment in the community and at a specialty clinic. Pediatrics. 2008; 122(2):273—278. doi:10.1542/peds.2007-1307

5. Murphy M.L., Pichichero M.E. Prospective identification and treatment of children with pediatric autoimmune neuropsychiatric disorder associated with group A streptococcal infection (PANDAS). Arch Pediatr Adolesc Med. 2002 Apr;156(4):356—361.

6. Morandi P.A., Deom A., Mauris A. External quality control of direct antigen tests to detect group A streptococcal antigen. Eur. J. Clin. Microbiol. Infect. Dis. 2003;22:670—674.

7. Steed L.L., Korgenski K., Daly J.A. Rapid detection of Streptococcus pyogenes in pediatric patient specimens by DNA probes. J. Clin. Microbiol. 1993;31:2996—3000.

8. Garvey M.A., Giedd J., Swedo S.E. PANDAS: the search for environmental triggers of pediatric neuropsychiatric disorders. Lessons from rheumatic fever. J Child Neurol. 1998 Sep;13(9):413—423. Doi: 10.1177/088307389801300901

9. Cox C.J., Sharma M., Leckman J.F., Zuccolo J., Zuccolo A., Kovoor A. Brain human monoclonal autoantibody from Sydenham chorea targets dopaminergic neurons in transgenic mice and signals dopamine D2 receptor: Implications in human disease. The Journal of Immunology. 2013;191(11):5524—5541.

10. Hoffman K.L., Hornig M., Yaddanapudi K., Jabado O., Lipkin W.I. A murine model for neuropsychiatric disorders associated with group A beta-hemolytic streptococcal infection. J Neurosci. 2004 Feb 18; 24(7):1780—1791.

11. Orlovska S., Vestergaard C.H., Bech B.H., Nordentoft M., Vestergaard M., Benros M.E. Association of streptococcal throat infection with mental disorders: Testing key aspects of the PANDAS hypothesis in a nationwide study. JAMA Psychiatry. 2017; 74(7):740— 746.

12. Спирин Н.Н., Степанов И.О., Касаткин Д.С., Шипова Е.Г. Диагностика, дифференциальная диагностика и принципы терапии острого рассеянного энцефаломиелита. Неврология и ревматология. (Consilium Medicum. Прил.) 2008; 02:23—28. Spirin N.N., Stepanov I.O., Kasatkin D.S., Shipova E.G. Diagnosis, differential diagnosis and treatment principles of acute disseminated encephalomyelitis. Neurology and Rheumatology (Suppl. Consilium Medicum). 2008; 02: 23—28. (In Russ.)

13. Селивёрстов Ю.А., Клюшников С.А. Дифференциальная диагностика хореи. Нервные болезни. 2015; 1: 6—15. Seliverstov Yu.A., Klyushnikov S.A. Differential diagnosis of chorea. Nervnye Bolezni. 2015; 1: 6—15. (In Russ.)

14. Харитонов В.И., Винник Ю.М., Селюков Г.И. Диагностика и лечение синдрома PANDAS. Описание случая. Русский журнал детской неврологии. 2014; 3:48—50. Kharitonov V.I., Vinnik Yu.M., Selyukov G.I. Diagnosis and treatment of PANDAS syndrome. Description of the case. Russkij Zhurnal Detskoj Nevrologii. 2014; 3:48—50. (In Russ.)

15. Белов Б.С., Насонова В.Л., Кузьмина Н.Н. Острая ревматическая лихорадка: современные этиопатогенетические аспекты. Научно-практическая ревматология. 2008; 5:51—58. Belov B.S., Nasonova V.L., Kuzmina N.N. Acute rheumatic fever: modern etiopathogenetic aspects. Nauchno-prakticheskaya Revmatologiya. 2008; 5:51—58. (In Russ.)

16. Cardoso F., Vargas A.P., Oliveira L.D., Guerra A.A., Amaral S.V. Persistent Sydenham's chorea. Movement Disorders. 1999; 14(5):805—807.

17. Snider L.A., Sachdev V., MacKaronis J.E., St Peter M., Swedo S.E. Echocardiographic findings in the PANDAS subgroup. Pediatrics. 2004;114(6):e748—e751.

18. Calaprice D., Tona J., Murphy T.K. Treatment of Pediatric Acute-Onset Neuropsychiatric Disorder in a Large Survey Population. J Child Adolesc Psychopharmacol. 2018; 28(2):92—103. doi:10.1089/cap.2017.0101


Review

For citations:


Uspenskaya T.L., Vinogradova T.V., Ipatova S.L., Sitnikova E.P., Kasatkin D.S. Pediatric autoimmune neuropsychiatric disorder associated with Streptococcal infection (PANDAS syndrome): real-world practice and clinical case. CHILDREN INFECTIONS. 2019;18(3):53-56. (In Russ.) https://doi.org/10.22627/2072-8107-2019-18-3-53-56

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ISSN 2072-8107 (Print)
ISSN 2618-8139 (Online)