To the issue of differential diagnosis of listeriosis
https://doi.org/10.22627/2072-8107-2019-18-3-61-66
Abstract
A clinical example shows the erroneous diagnosis of listeriosis in a 15-year-old child hospitalized in the infectious department. The child was admitted with severe symptoms of intoxication, febrile fever, difficulty in nasal breathing, hyperemia of the mucous membranes of the oropharynx, tonsillitis, cervical lymphadenitis, facial tissue pasteness with swelling of the eyelid and conjunctivitis of the left eye, hepatosplenomegaly. A laboratory examination revealed pronounced leukocytosis up to 24 thousand, lymphocytosis, atypical mononuclear cells up to 9%, IgM and IgG to EBV capsid protein, IgM to CMV, IgM and IgG to listeria. But with a repeated double study of IgM and IgG to Listeria were not detected. The initial positive result was possibly due to the presence of cross-reacting antibodies in EBV mononucleosis. The final diagnosis was made: Infectious mononucleosis of mixed (EBV, CMV) etiology. Chronic polypous rhinosinusitis, exacerbation. Reactive edema of the eyelids against the background of inflammation of the sinuses.
Given the variety of clinical forms of listeriosis and their similarity with the manifestations of other infections, for the full diagnosis of listeriosis infection, it is advisable to evaluate the epidemiological and medical history data, as well as use an extended spectrum of laboratory confirmation of the diagnosis.
About the Authors
O. V. Kladova
Russian National Research Medical University named after N.I. Pirogov;
Morozov Children's City Clinical Hospital
Russian Federation
Russian Federation
M.D., Professor, Department of Infectious Diseases in Children
infectious diseases doctor cdts
A. E. Andzhel
Morozov Children's City Clinical Hospital
Russian Federation
Russian Federation
Yu. V. Kompaniets
Morozov Children's City Clinical Hospital
Russian Federation
Russian Federation
N. L. Grishkevich
Morozov Children's City Clinical Hospital
Russian Federation
Russian Federation
References
1. Charles N., Haasl L.D., Rose J.B., Gerba C.P. A quantitative risk assessment model for listeria monocytogenes and E.coli 0157:H7. Extended abstract of a paper presented a the 1998 jamfes meeting, 1989.
2. Честнова Т.В. Эпизоотолого-эпидемиологические аспекты листериоза в Тульской области: автореф. дис.. к.б.н. — Тула, 1999: 20. Chestnova T.V. Epizootological and epidemiological aspects of listeriosis in the Tula region: abstract of the dissertation ... PhD (Biology). Tula, 1999:20. (In Russ.)
3. Информационный сборник статистических и аналитических материалов. Инфекционная заболеваемость в субъектах Российской Федерации в 2017—2018 гг. Часть 3. М.: Федеральный центр гигиены и эпидемиологии Роспотребнадзора. 2018. Information collection of statistical and analytical materials. Infectious morbidity in the constituent entities of the Russian Federation in 2017—2018. Part 3. M.: Federal Center for Hygiene and Epidemiology of Rospotrebnadzor. 2018. (In Russ.)
4. Ермолаева С.А., Тартаковский И.С. Регуляция экспрессии факторов вирулентности у Listeria monocytogenes. Журн. Микробиол. 2001. 3:106—110. Ermolaeva S.A., Tartakovsky I.S. Regulation of the expression of virulence factors in Listeria monocytogenes. Zhurn. Microbiol. 2001.3: 106—110. (In Russ.)
5. Тартаковский И. С., Малеев В. В., Ермолаева С. А. Листерии: роль в инфекционной патологии человека и лабораторная диагностика. Москва: Медицина для всех, 2002. Tartakovsky I.S., Maleev V.V., Ermolaeva S.A. Listeria: role in human infectious pathology and laboratory diagnostics. Moskva: Meditsina dlya vsekh, 2002. (In Russ.)
6. Carlo Spanu, Christian Scarano, Michela Ibba, Vincenzo Spanu, Enrico Pietro Luigi De Santis. Occurrence and traceability of Listeria monocytogenes strains isolated from sheep's milk cheese-making plants environment. Department of Veterinary Medicine, University of Sassari, Via Vienna 2, 07100 Sassari, Italy. Food Control. 2015; 47:318—325.
7. Joanne Thimothe, Kendra Kerr Nightingale, Ken Gall, Virginia N. Scott, and Martin Wiedmann. Tracking of Listeria monocytogenes in Smoked Fish Processing Plants. Journal of Food Protection. February 2004, 67(2):328—341.
8. Цинзерлинг А.В., Мельникова В.Ф. Перинатальные инфекции: Руководство для врачей. С-Пб, 2002:296—297. Tsinserling A.V., Melnikova V.F. Perinatal Infections: A Guide for Physicians. St. Petersburg, 2002: 296—297. (In Russ.)
9. Рогожин Д.В., Ожегов А.М., Зворыгин С.А. Листериоз у детей Педиатрия. 2004; 4:71—76. Rogozhin D.V., Ozhegov A.M., Zvorygin S.A. Listeriosis in children Pediatriya=Pediatrics. 2004; 4: 71—76. (In Russ.)
10. Wiedmann M., Bruce J.L., Keating C., Johnson A.E., McDonough P.L., Batt C.A. Ribotypes and virulence gene polymorphism suggest three distinct Listeriamonocytogenes lineages with differences in pathogenic potential. Infect. 1997. 65: 2707—2716.
11. Храмов М.В., Костенко Ю.Г, Батаева. Листериоз: лабораторная диагностика в современнных условиях: Материалы II Национального конгресса бактериологов. 2016; 6(3). Khramov M.V., Kostenko Yu.G., Bataeva. Listeriosis: laboratory diagnostics in modern conditions. Materials of the II National Congress of Bacteriologists. 2016; 6(3). (In Russ.)
12. Профилактика листериоза у людей. Санитарно-эпидемиологические правила. СП 3.1.7.2817-10. от 29.12.2010 №186. Prevention of listeriosis in humans. Sanitary and epidemiological rules. SP 3.1.7.2817-10. dated December 29, 2010 №186. (In Russ.)
13. Организация и проведение дезинфекционных мероприятий на различных объектах в период подготовки и проведения массовых мероприятий: Методические рекомендации. МР 3—5.0071—13. М., 2013. Organization and conduct of disinfection measures at various facilities during the preparation and conduct of public events: Methodological recommendations. MP 3-5.0071-13. M., 2013. (In Russ.)
Review
For citations:
Kladova O.V., Andzhel A.E., Kompaniets Yu.V., Grishkevich N.L. To the issue of differential diagnosis of listeriosis. CHILDREN INFECTIONS. 2019;18(3):61-66. (In Russ.) https://doi.org/10.22627/2072-8107-2019-18-3-61-66
Views:
762
Email this article 