Features of fungal colonization of newborns from mothers with vulvovaginitis
https://doi.org/10.22627/2072-8107-2020-19-2-19-22
Abstract
The aim of this study was to determine the frequency and etiological structure of fungal colonization of newborns from mothers with vaginal infections taking into account the methods of delivery, gestational age and body weight of the child.
Material and methods. 80 women clinically suspicious of fungal vulvovaginitis were examined at 16—22 weeks of gestation. Samples from the loci of probable fungal colonization in their children (81 newborns, one twins) were collected on 2—3 and 10—5 days of life. Samples were plated on Sabouraud agar and Czapek agar, followed by species identification by API Candida — api 20 C AUX yeast assay.
Results. Positive results were found in 23 (28.8%) mothers (Candida spp.) And 44 (54.3%) newborns (Candida spp., Aspergillus flavus, Penicillium expansum Link, Mucor racemosus). Isolates of 7.4% of full-term infants were completely identical to the maternal microflora (Candida spp.). The remaining 19 (23.5%) premature infants were found to have molds of fungi, which indicates the nosocomial nature of the infection. A statistically significant relationship between the type of delivery and fungal colonization in newborns was found in the early neonatal period (2—3 days of life).
About the Authors
A. S. Eiberman
Saratov State Medical University of V.I. Razumovsky
Russian Federation
Russian Federation
Alexander Eiberman, MD, Professor of Department of Pediatrics and Neonatology
Saratov
Y. V. Chernenkov
Saratov State Medical University of V.I. Razumovsky
Russian Federation
Russian Federation
Yuriy Chernenkov, MD, Professor, Head of the Department of Pediatrics and Neonatology
Saratov
L. G. Bochkova
Saratov State Medical University of V.I. Razumovsky
Russian Federation
Russian Federation
Larisa Bochkova, PhD, Associate Professor of the Department of Pediatrics and Neonatology
Saratov
References
1. Stock I. Fungal diseases of vulva and vagina caused by Candida species. Med Monatsschr Pharm. 2010; 33(9):324-33,335-6.
2. Zisova L.G., Chokoeva A.A. , Amaliev G.I., Petleshkova P.V., Miteva-Katrandzhieva T.M., Krasteva M.B., Uchikova E.H., Kouzmanov A.H., Ivanova Z.V. Vulvovaginal Candidiasis in Pregnant Women and its Importance for Candida Colonization of Newborns. Folia Medica. 2016; 58 (2):108—113.
3. Mendling W., Brasch J., Cornely O.A., Effendy I., Friese K., GinterHanselmayer G., Hof H., Mayser P.A., Mylonas I., Ruhnke M., Schaller M., Weissenbacher E-R. Guideline: vulvovaginal candidosis (excluding chronic mucocutaneous candidosis). Mycoses. 2015; 58 (1):1—15.
4. Gonçalves B., Ferreira C., Alves C.T., Henriques M., Azeredo J., Silva S. Vulvovaginal candidiasis: Epidemiology, microbiology and risk factors. Crit RevMicrobiol. 2015; 21:1—23.
5. Bulik C.C., Sobel J.D., Nailor M.D. Susceptibility profi le of vaginal isolates of Candida albicans prior to and following fluconazole introduction — impact of two decades. Mycoses. 2011; 54(1):34—8.
6. Broberg A., Thirnger K. Congenital cutaneous candidiasis. Int J Dermatol. 1989; 28:464—65.
7. Blaschke-Hellmessen R. Vertical transmission of Candida and its consequences. Mycoses. 1998; 41(2): 31—36.
8. Filippidi A., Galanakis E., Maraki S., Galani I., Drogari-Apiranthitou M., Kalmanti M., Mantadakis E., Samonis G. The effect of maternal flora on Candida colonization in the neonate. Mycoses. 2014; 57(1):43—8.
9. Alfei A., Rizzo A., Cavanna C., Lallitto F., Spinillo A. Candida glabrata and pre-term premature rupture of membrane complicating in vitro pregnancy: case report and confirmation of mother to neonate transmission. Arch Gynecol Obstet. 2014; 290(2):211—4.
10. Caramalac D.A., da Silva Ruiz L., de Batista G.C., Birman E.G., Duarte M., Hahn R., Paula C.R. Candida isolated from vaginal mucosa of mothers and oral mucosa of neonates: occurrence and biotypes concordance. Pediatr Infect Dis J. 2007; 26(7):553—7.
11. Методические указания по проведению микологических исследований патологического материала и кормов в ветеринарно-бактериологических лабораториях при диагностике микозов и микотоксикозов сельскохозяйственных животных (Утверждены Государственной инспекцией по ветеринарии Министерства сельского хозяйства СССР 24 июля 1959 года) М., 1959: 10—13; 14—15. [Methodical instructions for mycological research of pathological material and feed in veterinary and bacteriological laboratories in the diagnosis of mycosis and mycotoxicosis of farm animals (Approved by the State Ministry of Agriculture Ministry of Agriculture 24 July 1959) M., 1959: 10—13; 14—15. (In Russ.)]
12. Ferrer J. Vaginal candidosis: epidemiological and etiological factors. Int J Gynaecol Obstet. 2000; 71(1):21—27.
13. Taheri B.J., Mortazavi H., Mohammadi S., Bakhtiari S., Namazi F., Valaei N., Bakhshi M., Baharvand M., Bahemmat N. Evaluation of Candida isolation from vaginal mucosa of mothers and oral mucosa of neonates on the basis of delivery type. Afr J Microbiol Res. 2011; 5:5067—70.
14. Bendel C.M. Colonization and epithelial adhesion in the pathogenesis of neonatal candidiasis. Semin Perinatol. 2003; 27:357—64.
Review
For citations:
Eiberman A.S., Chernenkov Y.V., Bochkova L.G. Features of fungal colonization of newborns from mothers with vulvovaginitis. CHILDREN INFECTIONS. 2020;19(2):19-22. (In Russ.) https://doi.org/10.22627/2072-8107-2020-19-2-19-22
Views:
622
Email this article 