Seroprevalence of primary health care workers in Saint-Petersburg during a measles epidemic
https://doi.org/10.22627/2072-8107-2020-19-3-51-57
Abstract
The measles situation is still unstable — there are imported cases, the formation of nosocomial foci with the involvement of medical personnel, patients and visitors of medical institutions.
Objective of the study: to assess the level of seroprevalence of primary health care workers in St. Petersburg during the period of epidemic trouble with measles.
Materials and methods: An open retrospective randomized uncontrolled study of the intensity of specific immunity to measles in 980 employees aged 18 to 78 years, examined in July-September 2018, was carried out. The level of anti-measles IgG antibodies was determined by the method of enzyme-linked immunosorbent assay (810 people) and passive hemagglutination reactions (170 people). The results are presented with the indication of the shares (%) and the calculation of the 95% confidence interval according to Clopper — Pearson. Differences between groups were assessed using Pearson's chi-square test (%2). Differences in the groups were considered statistically significant when the criterion level was p < 0.05.
Results: It was found that 8.2% of personnel are not protected against measles infection. At the same time, the number of seronegative persons among doctors (8.1 %), nurses (7.7%) and non-medical workers (9.6%) differed statistically. Age-related differences in the immune layer were revealed — the greatest susceptibility was observed in persons under 30 years of age (1 8.3%). Anti-measles antibodies in those who had been ill persisted for a long time and at a high level. At the same time, the intensity of post-vaccination immunity decreased over time, and 20 years after immunization, the number of seronegative individuals increased significantly. Only 64.1 % of those surveyed had two vaccinations, more than a third were immunized once. Nevertheless, the proportion of people unprotected from measles exceeded the criterion of epidemic well-being with the same frequency in both groups (9.2% and 1 0.4%, respectively).
The results of a serological study showed that the presence of a record of two vaccinations in the certificate in 9.2% of cases does not guarantee protection in case of contact with a patient with measles. Only a serological examination is evidence of specific immunity to measles infection.
About the Authors
T. M. ChemovаRussian Federation
Tatyana М. Chernova - MD, PhD, аssociate Professor, Department of Infectious Diseases in Children named after Professor M.G. Danilevich
V. N. Timchenko
Russian Federation
Vladimir N. Timchenko - MD, professor
St. PetersburgE. V. Barakina
Russian Federation
PhD, assistant
St. Petersburg
E. B. Pavlova
Russian Federation
Elena Pavlova - PhD, associate Professor.
Saint Petersburg
A. N. Nazarova
Russian Federation
Anna N. Nazarova - PhD, assistant.
Saint Petersburg
А. L. Balashov
Russian Federation
Alexei L. Balashov - PhD, associate Professor.
Saint Petersburg
I. A. Egorova
Russian Federation
Irina A. Egorova
Saint Petersburg
Е. L. Kostritsa
Russian Federation
Elena L. Kostritsa
Saint Petersburg
A. A. Zherebtsova
Russian Federation
Anastasia А. Zherebtsova
Saint Petersburg
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Review
For citations:
Chemovа T.M., Timchenko V.N., Barakina E.V., Pavlova E.B., Nazarova A.N., Balashov А.L., Egorova I.A., Kostritsa Е.L., Zherebtsova A.A. Seroprevalence of primary health care workers in Saint-Petersburg during a measles epidemic. CHILDREN INFECTIONS. 2020;19(3):51-57. (In Russ.) https://doi.org/10.22627/2072-8107-2020-19-3-51-57