Botulism in the Astrakhan region: a retrospective study
https://doi.org/10.22627/2072-8107-2021-21-1-33-40
Abstract
The average number of annually registered cases of botulism in the Russian Federation is 300. At the same time, there is an increase in the number of deaths to 26 per year.
Materials and methods. The article presents the results of a clinical and epidemiological analysis of 47 cases of botulism in adults treated at the State Medical Institution «Regional Infectious Clinical Hospital named after A.M. Nichoga» in Astrakhan in the period from 2009 to 2019. The diagnosis of botulism was confirmed by a positive reaction of biological neutralization of the toxin in white mice.
Results. It is established that the epidemic process of botulism in the Astrakhan region is characterized mainly by sporadic morbidity in adults of working age and the absence of cases of the disease in children. All patients had food botulism, which occurred typically in the form of moderate and severe forms of the disease, with a mortality rate of 4.2%. There is an increase in the share of fish and fish products, non-industrial preparation, as sources of infection. Laboratory confirmation of botulism occurred in 60% of patients.
About the Authors
G. A. Kharchenko
Astrakhan state medical University of the Ministry of health of Russia
Russian Federation
Russian Federation
MD, Professor
Astrakhan
O. G. Kimirilova
Astrakhan state medical University of the Ministry of health of Russia
Russian Federation
Russian Federation
PhD, Associate Professor
Astrakhan
A. A. Kimirilov
Regional infectious diseases clinical hospital named A. M. Nichogy
Russian Federation
Russian Federation
resuscitator
Astrakhan
References
1. Infectious diseases: National guidelines. Ed. N.D. Yushchuk, Yu.A. Vengerov, M.: GEOTAR-Media; 2009. (In Russ.)
2. Noskova O.A., Zagoskina T.Yu., Uldanova D.S., Dubina L.E. Clinical and epidemiological features of botulism in the Trans-Baikal Territory. Epidemiology and Vaccination revention=Epidemiologiya i Vakcinoprofilaktika. 2013; 6: 45—48. (In Russ.)
3. Official website of the Department of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare in the Belgorod region. URL: http://31.rospotrebnadzor.ru (accessed: 30.09.2021). (In Russ.)
4. The official website of the Federal Center for Hygiene and Epidemiology of the Federal Service for Supervision of Consumer Rights Protection and Human Well-Being. URL: http://fcgie.ru (accessed: 30.09.2021). (In Russ.)
5. Healthcare of Russia. Statistical collection. M.: 2019. (In Russ.)
6. Makarova I.V., Osipov A.V., Ioannidi E.A. Clinical and epidemiological characteristics of food botulism in Volgograd. VestnikVolg GMU= VestnikVolg GMU. 2014;1(49):52—54. (In Russ.)
7. Nikiforov V.N., Nikiforov V.V. Botulism. Leningrad: Meditsina; 1985. (In Russ.)
8. Yushchuk N.D., Vengerov Yu.Ya., Kryazheva S.S. Infectious human diseases: Handbook. M.: Medicine, 2009:40—41. (In Russ.)
9. Urazbakhtina Z.A. Tactics of emergency care for botulism. Clinical Мedicine= Klinicheskaya Мedicina. 2014; 1:57—59. (In Russ.)
10. Goonetilleke A. Clostridial neurotoxins. J. Neurol. Neurosurg. Psychiatry, 2004; 75:35—39.
11. Horowitz B.Z. Botulinum toxin. Crit. Care Clin. 2005; 21: 825—39.
12. Cox N. Infant Botulism. Am. Fam. Physician. 2002; 65:1388—92.
13. Botulism in children (epidemiology, etiology, diagnosis, clinic, therapy, prevention): Manual for doctors. Еd. рrof. N.V. Skripchenko. St. Petersburg, 2007. (In Russ.)
14. Sobel J. Botulism. Clin. Infect. Dis. 2005; 41(8):1167—1173.
15. Tosheva Sh.A., Rakhmanov E.R. Gulyamova N.M., Galiev H.G. Clinical and epidemiological aspects of botulism and its treatment. Health Care of Tajikistan=Zdravoohranenie Tadzhikistana. 2009; 1:57—59. (In Russ.)
16. Jaeger A. Botulism as warfare agent: features, management and treatment. Clin. Toxicol. 2002; 40: 244—6.
17. Sumin S.A. Urgent conditions: A textbook. 7th ed., reprint. and additional M.: ООО «Medical Information Agency», 2010. (In Russ.)
18. Bykov M.V., Bykov D.F., Lazarev V.V., Gorelov A.V. Questions of intensive therapy of severe forms of botulism. RMJ «Medical Review»=RMZH «Medicinskoe obozrenie», 2018; 8:88—91. (In Russ.)
19. Merson M.H., Dowell V.R. Epidemiologic clinical and laboratory aspect of wound Botulism. New. Engl. J. Med. 1973; 289:1005—1010.
20. Instructions for the use of anti-botulinum serums of types A, B, E purified concentrated liquid. Approved by the Chief State Sanitary Doctor of the Russian Federation Onishchenko G. G. 17. 02.2000. (In Russ.)
21. Nikiforov V.V., Tomilin Yu.N. Botulism therapy: problems and solutions. International Medical Journal=Mezhdunarodnyj med. zhurnal. 2005; 2:119—123. (In Russ.)
22. Nikiforov V.V. Botulism. In the book: Infectious Diseases National Guide. Ed. N.D. Yushchuk, Yu.a. Vengerov. 2nd edition revised and enlarged. M.: GEOTAR-Media, 2018: 558-568. (In Russ.)
23. Ermak T.N. Botulism. In the book Intensive Care National Guide. Еd. Zabolotskikh I.B., Protsenko D.N. 2nd edition revised and supplemented. Volume-2. Moscow: GEOTAR-Media, 2020:576—582. (In Russ.)
24. Nikiforov V.V., Tomilin Yu.N., Chernobrovkina T.Ya., Yankovskaya Ya.D., Burova S.V. Difficulties of early diagnosis and treatment of botulism. Archive of Internal Medicine. 2019; 4:253—259. (In Russ.)
Review
For citations:
Kharchenko G.A., Kimirilova O.G., Kimirilov A.A. Botulism in the Astrakhan region: a retrospective study. CHILDREN INFECTIONS. 2022;21(1):33-40. (In Russ.) https://doi.org/10.22627/2072-8107-2021-21-1-33-40
Views:
590
Email this article 