THE CLINICAL EFFICACY OF HYPOOSMOLYARNY ORAL SOLUTION WITH LACTOBACILLUS GG FOR REHYDRATION IN INTESTINAL INFECTIONS IN CHILDREN
https://doi.org/10.22627/2072-8107-2015-14-1-20-26
Abstract
In 60 patients with moderate forms of the OCI «osmotic» (76.7%) and «invasive» (23.3%) such as diarrhea, aged 3—12 years, to evaluate the clinical effectiveness, impact on water and electrolyte metabolism, acid-base balance and intestinal microbiocenosis hypoosmolyarny solution with Lactobacillus rhamnosus GG «Regidron Bio» (30 patients) and hyperosmolarny solution (30 patients). It was found that in the group of patients receiving «Regidron Bio», in contrast to the hyperosmolarny solution, is rapidly disappearing symptoms of intoxication and exsicosis, abdominal pain, meteorism and liquid watery diarrhea. The average duration of the acute period is reduced from 4,06 ± 0,32 to 3,07 ± 0,27 day (P < 0,05). Already by the end of the 1st day of the beginning of rehydration, almost all patients (90%) are normalized malformations of blood electrolytes and glucose, hematocrit, and on the 2nd day, which took place in 80% of patients with metabolic acidosis. The addition of the «Bio rehydron» Lactobacillus rhamnosus GG facilitates, unlike hyperosmolarny solution indicator normalizing lg Lactobacilli (in 73.3%) and Enterococci (93.3%), but has no significant positive impact on the amount of Bifidobacteria and Escherichia coli.
About the Authors
V. F. Uchaikin
Russian National Research Medical University named after N.I. Pirogov, Moscow
Russian Federation
Russian Federation
A. A. Novokshonov
Russian National Research Medical University named after N.I. Pirogov, Moscow
Russian Federation
СMS, Professor of department of infection diseases in children; Russian National Research Medical University; Moscow; (499) 256-60-26
Russian Federation
СMS, Professor of department of infection diseases in children; Russian National Research Medical University; Moscow; (499) 256-60-26
References
1. Современные принципы пероральной регидратации при лечении острых кишечных инфекций у детей / А.Е. Абатуров и др. // Здоровье ребенка. — 2012. — 2 (37). http://www.mif-ua.com/ archive/article/27266. Sovremennyie printsipyi peroralnoy regidratatsii pri lechenii ostryih kishechnyih infektsiy u detey [. Modern principles of oral rehydration therapy in the treatment of acute intestinal infections in children] / A.E. Abaturov i dr. // Zdorove Rebenka. — 2012. — 2(37). http:// www.mif-ua.com/archive/article/27266. (In Russ).
2. Антоненко О.М. Пероральная регидратационная терапия — основной патогенетический метод в лечении ротавирусной ин-фекции // Consilium medicum. Гастроэнтерология. — 2010. — № 1. — С. 60—63. Antonenko O.M. Peroralnaya regidratatsionnaya terapiya — osnovnoy patogeneticheskiy metod v lechenii rotavirusnoy infektsii [Oral rehydration therapy — the main pathogenetic method in the treatment of rotavirus infection ] // Consilium Medicum. Gastroenterologiya. 2010. — N 1. — S.60—63. (In Russ).
3. Munos M.K., Walker C.L., Black R.E. The effect of oral rehydration solution and recommended home fluids on diarrhoea mortality // Int. J. Epidemiol. — 2010. — V. 39 (suppl. 1). — P. i75—87.
4. Халиуллина С.В. Обезвоживание у детей при острых диареях / С.В. Халиуллина, В.А. Анохин, Ю.Р. Урманчеева // Детские инфекции. —2014. — Т 13. —№ 3. —С. 40—44. Haliullina S.V. Obezvozhivanie u detey pri ostryih diareyah [Dehydration in children with acute diarrhea ] /S.V. Haliullina, V.A. Anohin, Yu.R. Urmancheeva // Detskie Infektsii. — 2014. — tom 13. — № 3. — S.40—44. (In Russ).
5. Claeson M., Merson M.H. Global progress in the control of diarrheal diseases // Pediatr. Infect. Dis. J. — 1990. — V. 9. — № 5. — P. 345—355.
6. Uchendu U.O., Emodi I. J., Ikefuna A.N. Pre-hospital management of diarrhoea among caregivers presenting at a tertiary health institution: implications for practice and health education // Afr. Health Sci. — 2011. — V. 11. — № 1. — P. 41—47.
7. WHO/UNICEF. WHO-UNICEF Joint statement on the clinical management of acute diarrhea. — Geneva, Switzerland: World Health Assembly. — 2004.
8. Walker-Smith J.A., Sandhu B.K., Isolauri E. et al. Guidelines Prepared by the ESPGAN Working Group on Acute Diarrhoea: Recommendations for Feeding in Childhood Gastroenteritis [Medical Position Paper] // J. Pediatr. Gastroenterol. Nutrition. — 1997. — 24 (5) : 619—20.
9. Wapnir R.A. Recent Progress and Future Aims in the Formulation and Use of Oral Rehydration Solutios // International Pediatrics. — 2000. — 15 (4) : 205—13.
10. CHOICE Study Group. Multicenter, randomized, double-blind clinical trial to evaluate the efficacy and safety of a reduced osmolarity oral rehydration salts solution in children with acute watery diarrhea // Pediatrics. — 2001. — V. 107. — № 4. — P. 613—618.
11. Recent Progress and Future Aims in the Formulation and Use of Oral Rehydration Solutios / Wapnir R.A. // International Pediatrics. — 2000. — V. 15. — № 4. — Р. 205—213.
12. The effect of oral rehydration solution and recommended home fluids on diarrhoea mortality / Munos M.K., Fischer-Walker C.L., Bkack R.E. // International J. Epidemiology. — 2010. — № 39. — Р. i75—87.
13. Новокшонов А.А. Пероральная регидратационная терапия при кишечных инфекциях у детей — новые стандарты состава солевых растворов /А.А. Новокшонов, Н.В. Соколова // Детские инфекции. —2010. — № 4. — С. 57—61. Novokshonov A.A. Peroralnaya regidratatsionnaya terapiya pri kishechnyih infektsiyah u detey — novyie standartyi sostava solevyih rastvorov [Oral rehydration therapy in intestinal infections in children — new standards of salt solutions ] /A.A.Novokshonov, N.V. Sokolova // Detskie Infektsii. — 2010. — № 4. — S. 57—61. (In Russ).
14. Мазанкова Л.Н. Современные рекомендации по лечению ост-рого гастроэнтерита у детей / Л.Н. Мазанкова, С.Г. Горбунов // Фарматека. — 2014. — № 6. — С. 68—73 http://www.medvestnik.ru/library/article/13248. Mazankova L.N. Sovremennyie rekomendatsii po lecheniyu ostro-go gastroenterita u detey [Current recommendations for the treatment of acute gastroenteritis in children ] / L.N.Mazankova, S.G.Gorbunov // Farmateka. — 2014. — № 6. — S. 68—73 ht-tp://www.medvestnik.ru/library/article/13248. (In Russ).
15. Многоцентровое исследование применения Lactobacillus GG с пероральным раствором для регидратации у детей с острой ди-ареей /De Marco G, Guarino A., Passariello A., Manguso F. // Department of Paediatrics, University of Naples Federico II, Naples, Italy. — 2010. — http://medstrana.com/articles/682. Mnogotsentrovoe issledovanie primeneniya Lactobacillus GG s peroralnyim rastvorom dlya regidratatsii u detey s ostroy diareey [A multicenter trial of Lactobacillus GG to oral rehydration solution for children with acute diarrhea ] / De Marco G, Guarino A., Pas-sariello A, Manguso F. // Department of Paediatrics, University of Naples Federico II, Naples, Italy. 2010 http://medstrana.com/articles/682. (In Russ).
16. Физиологические функции лактобактерий в организме и эффективность их применения в составе пробиотиков в педиатрической практике / А.А. Новокшонов, Н.В. Соколова // Эффективная фармакотерапия. Эпидемиология и инфекции. — 2013. — № 2. — С. 52—56. Fiziologicheskie funktsii laktobakteriy v organizme i effektivnost ih primeneniya v sostave probiotikov v pediatricheskoy praktike [The physiological functions in the organism Lactobacillus and efficiency of their use in the pediatric probiotics] / A.A. Novokshonov, N.V. Sokolova // Effektivnaya Farmakoterapiya. Epidemiologiya i Infektsii. M. — 2013. — № 2. — S. 52—56. (In Russ).
17. Goldin B.R., Gorbach S.L., Saxelin M., Barakat S., Gualtieri L., Salminen S. Survival of Lactobacillus species (strain GG) in human gastrointestinal tract // Dig Dis Sci. — 1999. — 37 : 121—8.
18. DuPont H.L. Lactobacillus GG in prevention of traveler's diarrhea: An encouraging first step. // J. Travel Med. — 1997. — 1—2. 4.
19. Hilton E., Kolakowoski P., Singer C., Smith M. Efficacy of Lactobacillus GG as a diarrheal preventive in travelers. // J. Travel Med. — 1999. — 4 : 41—3.
20. Isolauri E., Juntunen M., Rautanen T., Sillanaukee P., Koivula T. A human Lactobacillus strain (Lactobacillus casei strain GG) promotes recovery from acute diarrhea in children // Pediatrics. — 1999. — 88 : 90—7.
Review
For citations:
Uchaikin V.F., Novokshonov A.A. THE CLINICAL EFFICACY OF HYPOOSMOLYARNY ORAL SOLUTION WITH LACTOBACILLUS GG FOR REHYDRATION IN INTESTINAL INFECTIONS IN CHILDREN. CHILDREN INFECTIONS. 2015;14(1):20-26. (In Russ.) https://doi.org/10.22627/2072-8107-2015-14-1-20-26
Views:
1353
Email this article 