Norovirus infection in children: an analysis of their own observations
https://doi.org/10.22627/2072-8107-2024-23-3-35-39
Abstract
Norovirus infection (NVI) ranks second in the structure of intestinal infections of viral etiology in children, is the main cause of outbreaks in all age categories and accounts for up to 50—90% of group cases. The incidence of NVI in the Russian Federation and the Yaroslavl region remains at a fairly high level. Purpose of the study: analyze the clinical and laboratory features of norovirus infection in children. Materials and methods: the article presents literature data on the significance of the problem of NVI in children at the present stage and the results of our own observations of 1332 children hospitalized in the Infectious Diseases Clinical Hospital of Yaroslavl in the period from 2017 to 2022. Results: in the age structure of cases, children of the first three years of life predominated (59.0%); children under 1 year old were 10.3%. An increase in the number of severe forms of NVI has been noted. The severity is due to toxicosis with exicosis. In recent years, NVI occurs in combination with other pathogens of intestinal infections, as well as respiratory viruses, which aggravates the course of the underlying disease, creating an important practical significance of the problem.
About the Authors
E. G. Klimovitskaya
Yaroslavl State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Yaroslavl.
S. N. Eshmolov
Yaroslavl State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Yaroslavl.
M. N. Kuzmina
Yaroslavl State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Yaroslavl.
I. G. Sitnikov
Yaroslavl State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Yaroslavl.
References
1. Ermolenko K.D., Lobzin Yu.V., Gonchar N.V. Viral gastroenteritis in children: modern ideas about epidemiology and prevention. Zhurnal infektologii=Journal of Infectology. 2015; 7(3):22—32. (In Russ.)
2. Tsaregorodtsev A.D., Anokhin V.A., Khaliullina S.V. Acute infectious diarrhea in children. Modern features of epidemiology and clinical picture of diseases. Russian Bulletin of Perinatology and Pediatrics. 2015; 60(4):25—30. (In Russ.)
3. Shkarin V.V., Chubukova O.A., Blagonravova A.S., Sergeeva A.V. Problematic issues of the combination of intestinal infections. Zhurnal infektologii=Journal of Infectology. 2016; 8(4):11—19. (In Russ.)
4. Kovalev O.B., Molochkova O.V., Konyaev K.S., Pylaeva E.Yu., Anufrieva P.A. Kurmanova V.V., Korsunsky A.A., Kashchenko O.A., Galeeva E.V., Krylatova N.I. Etiology and clinical manifestations of acute intestinal infections in children, according to Moscow hospital data for 2016—2018. Detskie Infektsii=Children's Infections. 2019; 18(2):54—57. https://doi.org/10.22627/2072-8107-2019-18-2-54-57 (In Russ.)
5. Federal service for supervision of consumer rights protection and human welfare. Federal center for hygiene and epidemiology. Information about infectious and parasitic diseases in the Yaroslavl region for January-December 2022. (In Russ.) [https://76.rosstat.gov.ru/folder/36353 Date of access 23.04.24]
6. Kosova A.A., Chalapa V.I., Itani T.M., Semenov A.V. Epidemiological characteristics of norovirus infection. Ural'skiy meditsinskiy zhurnal=Ural Medical Journal. 2022; 21(3):114—128. http://doi.org/10.52420/2071-5943-2022-21-3-114-128 (In Russ.)
7. Pogan R., Dülfer J., Uetrecht C. Norovirus assembly and stability. Current Opinion in Virology. 2018; 31:59—65.
8. Ciofi-Silva C.L., Brunaa C.Q.M., Carmonab R.C.C., Inada N.M. [et al.]. Norovirus recovery from floors and air after various decontamination protocols. The Journal of Hospital Infection. 2019; 103(3):328—334.
9. de Graaf M., Villabruna N., Koopmans M. P. Capturing norovirus transmission. Current Opinion in Virology. 2017; 22:64—70.
10. Alsved M., Fraenkel C.-J., Bohgard М, Widell А. [et al.]. Sources of airborne norovirus in hospital outbreaks. Clinical Infectious Diseases. 2020; 70(10):2023—2028. DOI: 10.1093/cid/ciz584
11. Gustavsson L. Nordén R., Westin J., Lindh M., Andersson L.-M. [et al.]. Slowclearance of norovirus following infection with emerging variants of genotype GII.4 strains. Journal of Clinical Microbiology. 2017; 55(5):1533— 1539. doi: 10.1128/JCM.00061-17
12. Qi R., Huang Y., Liu J., Sun Y., [et al.]. Global Prevalence of AsymptomaticNorovirus Infection: A Meta-analysis. EClinicalMedicine. 2018; 2(3):50— 58. doi: 10.1016/j.eclinm.2018.09.001
13. Khokhlova N.I., Kapustin D.V., Krasnova E.I., Izvekova I.Ya. Norovirus infection (literature review). Zhurnal infektologii=Journal of Infectology. 2018; 10(1):5—14. (In Russ.)
14. Pronko N.V. Modern aspects of acute intestinal infections of viral etiology inchildren. Aktual'naâ Infektologiâ. 2018; 6(2):93—97. doi: 10.22141/2312-413x.6.2.2018.131096 (In Russ.)
15. Robilotti E, Deresinski S, Pinsky BA. Norovirus. Clin Microbiol Rev. 2015; 28(1):134—64.
16. Blazevic V., MalmМ., Honkanen Н., Knip М. [et al.]. Development and maturation of norovirus antibodies in childhood. Microbes and Infection. 2016; 18(4):263—269. DOI: 10.1016/j.micinf.2015.12.004
17. Woodward J., Gkrania-Klotsas E., Kumararatne D. Chronic norovirus infection and common variable immunodeficiency. Clin Exp Immunol. 2017; 188(3):363—370.
18. Beal S.G., Tremblay E.E., Toffel S., et al. A gastrointestinal PCR panel improves clinical management and lowers health-care costs. J Clin Microbiol. 2017. pii: JCM.01457-17.
19. Bartnicki E., Cunha J.B., Kolawole A.O., Wobus C.E. Recent advances in understanding noroviruses. F1000Res. 2017; 26(6):79. doi: 10.12688/f1000research.10081.1.eCollection
20. Galasiti Kankanamalage A.C., Weerawarna P.M., Kim Y., et al. Anti-norovirus therapeutics: a patent review (2010—2015). Expert Opin Ther Pat. 2016; 26(3):297—308.
Review
For citations:
Klimovitskaya E.G., Eshmolov S.N., Kuzmina M.N., Sitnikov I.G. Norovirus infection in children: an analysis of their own observations. CHILDREN INFECTIONS. 2024;23(3):35-39. (In Russ.) https://doi.org/10.22627/2072-8107-2024-23-3-35-39
Views:
289
Email this article 