Clinical case of infectious mononucleosis with facial neuropathy
https://doi.org/10.22627/2072-8107-2024-23-3-69-72
Abstract
Infectious mononucleosis is a current problem of pediatric practice, which tends to increase the incidence in the Russian Federation and other countries. Liver dysfunction of varying severity in infectious mononucleosis occur with a frequency of 17—90% of cases while Epstein-Barr neuroinfections of viral etiology occur in no more than 5% of patients. This article presents a clinical case of infectious mononucleosis with liver damage and right facial neuropathy in a 15-year-old child.
About the Authors
T. E. Shvets
Omsk State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Omsk.
E. A. Gashina
Omsk State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Omsk.
E. F. Lobova
Omsk State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Omsk.
References
1. Solomaj T.V. Dynamics of morbidity and territorial spread of infectious mononucleosis. Zdravooxranenie Rossijskoj Federacii. 2019; 63(4):186—192. (In Russ.) https://doi.org/10.18821/0044-197X-2019-63-4-186-192
2. Liu M, Wang X, Zhang L, Feng G, Zeng Y, Wang R, Xie Z. Epidemiological characteristics and disease burden of infectious mononucleosis in hospitalized children in China: A nationwide retrospective study. Virol Sin. 2022 Oct; 37(5):637—645. https://doi.org/10.1016/j.virs.2022.07.007.
3. Kulikova M.M., Solomay T.V., Semenenko T.A. Clinical and laboratory differences between primary acute and reactivation of chronic Epstein-Barr viral infection in children (systematic review and meta-analysis). Detskie Infektsii=Children's Infections. 2022; 21(1):49—55. (In Russ.) https://doi.org/10.22627/2072-8107-2022-21-1-49-55
4. Rutkowska M, Pokorska-Śpiewak M. Epstein Barr Virus Hepatitis-A Mild Clinical Symptom or a Threat? Vaccines (Basel). 2023 Jun 19; 11(6):1119. https://doi.org/10.3390/vaccines11061119
5. Bobroviczkaya A.I., Dubovaya A.V., Lepixova L.P., Zaxarova L.A., Karachaeva E.S. Some clinical and pathogenetic aspects of the primary form of Epstein-Barr viral infection in children Voennaya i Тakticheskaya Мedicina, Мedicina Neotlozhny`x Sostoyanij. 2022; 2(5):42—56. (In Russ.) https://doi.org/10.55359/2782-3296.2022.81.55.006
6. Zhang C, Cui S, Mao G, Li G. Clinical Characteristics and the Risk Factors of Hepatic Injury in 221 Children With Infectious Mononucleosis. Front Pediatr. 2022 Jan 12; 9:809005. https://doi.org/10.3389/fped.2021.809005
7. Leonardsson, H., Hreinsson, J. P., Löve, A., & Björnsson, E. S. Hepatitis due to Epstein-Barr virus and cytomegalovirus: clinical features and outcomes. Scandinavian Journal of Gastroenterology. 2017; 52(8):893—897. https://doi.org/10.1080/00365521.2017.1319972
8. Rostgaard K, Balfour HH Jr, Jarrett R, Erikstrup C, Pedersen O, Ullum H, Nielsen LP, Voldstedlund M, Hjalgrim H. Primary Epstein-Barr virus infection with and without infectious mononucleosis. PLoS One. 2019 Dec 17; 14(12):e0226436. https://doi.org/10.1371/journal.pone.0226436
9. Mazur-Melewska K, Breńska I, Jończyk-Potoczna K, et al. Neurologic Complications Caused by Epstein-Barr Virus in Pediatric Patients. Journal of Child Neurology. 2016; 31(6):700—708. https://doi.org/10.1177/0883073815613563
10. Tselis, AC. Chapter 13: Epstein-Barr virus infections of the nervous system. En: Handbook of Сlinical Neurology. 2014; 123:285—305.
11. Patel P. Neurological Complications Diseases of Epstein-Barr virus. 2022; J Clin Infect Dis Pract, 7:149. https://doi.org/10.4172/2476-213X.1000149
12. Soldan SS, Lieberman PM. Epstein-Barr Virus Infection in the Development of Neurological Disorders. Drug Discov Today Dis Models. 2020; 32(Pt A):35—52. https://doi.org/10.1016/j.ddmod.2020.01.001.
13. Skripchenko N.V., Lobzin V.V., Ivanova G.P., Komantsev V.N., Alekseeva L.A., Ivanova M.V., Vilnits A.A., Gorelik E.Yu., Skripchenko E.Yu. Neuroinfectious diseases in children. Detskie Infektsii=Children's Infections. 2014; 13(1):8—18. (In Russ.) https://doi.org/10.22627/2072-8107-2014-13-1-8-18
14. Karalok ZS, Taskin BD, Ozturk Z, Gurkas E, Koc TB, Guven A. Childhood peripheral facial palsy. Childs Nerv Syst. 2018 May; 34(5):911—917. https://doi.org/10.1007/s00381-018-3742-9
15. Özkale Y, Erol I, Saygí S, et al. Overview of pediatric peripheral facial nerve paralysis. J Child Neurol. 2014; 30(2):193—99.
16. Wohrer D, Moulding T, Titomanlio L, Lenglart L. Acute Facial Nerve Palsy in Children: Gold Standard Management. Children (Basel). 2022 Feb 17; 9(2): 273. https://doi.org/10.3390/children9020273
17. Irikova M.A., Skripchenko E.Yu., Voitenkov V.B., Marchenko N.V., Skripchenko N.V., Goleva O.V., Petrov I.B. Clinical and etiological features of peadiatric facial neuropathy and their role in predicting outcomes. Journal Infectology. 2023; 15(3):39—43. (In Russ.) https://doi.org/10.22625/2072-6732-2023-15-3-39-43
18. Bilge, S., Mert, G.G., Hergüner, M.Ö. et al. Peripheral facial nerve palsy in children: clinical manifestations, treatment and prognosis. Egypt J Neurol Psychiatry Neurosurg. 2022; 58:152. https://doi.org/10.1186/s41983-022-00596-1
19. Vogelnik K, Matos A. Facial nerve palsy secondary to Epstein-Barr virus infection of the middle ear in pediatric population may be more common than we think. Wien Klin Wochenschr. 2017 Nov; 129(21—22):844—847. https://doi.org/10.1007/s00508-017-1259-y
20. Álvarez-Argüelles ME, Rojo-Alba S, Rodríguez Pérez M, Abreu-Salinas F, de Lucio Delgado A, Melón García S. Infant Facial Paralysis Associated with Epstein-Barr Virus Infection. Am J Case Rep. 2019 Aug 17; 20:1216—1219. https://doi.org/10.12659/AJCR.917318
Review
For citations:
Shvets T.E., Gashina E.A., Lobova E.F. Clinical case of infectious mononucleosis with facial neuropathy. CHILDREN INFECTIONS. 2024;23(3):69-72. (In Russ.) https://doi.org/10.22627/2072-8107-2024-23-3-69-72
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